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        고혈압 환자의 혈압 일중변동 양상과 관련된 장기장애

        최창균(Chang Keun Choi),윤광식(Kwang Sik Yoon),이승복(Seung Bock Lee),정안철(An Chul Jeong),안병진(Byung Jun Ahn),문도호(Do Ho Moon),도승경(Sung Kyoung Doh),곽현진(Hyun Jun Kwak),김용훈(Yong Hoon Kim),이홍순(Hong Soon Lee),유수웅(Soo 대한내과학회 1998 대한내과학회지 Vol.55 No.1

        N/A Objective : Pattern with essential hypertension g ally shows the same circadian pattern as the normothensive person with a night-time reduction or DIP in blood pressure in sleep. The definition of Dipper and Non-dipper are assigned according to arbitrary criteria e.g. a night time average blood pressure which is at least 10% less than the average daytime blood pressure. Prospective evidence that the absence of an overnight dip is a strong adverse prognostic. indicator for target organ damage .Thus we investigate circardian rhythm of blood pressure, related target organ damage, its frequency & drug in hypertensive subjects. Method: 24hr ambulatory blood pressure monitoring, history taking, physical examination, fundoscopy, ECG, chest X ray, dipstick urinanlysis, serum creatinine level are performed in essential hypertensive subjects. Exclusion criteria are duration of hypertension over 5 years, DM, renovascular hypertension & heart failure. Results : Total 42 patients performed study.17 subjects classify dipper group,25 subjects classify non-dipper group. Between dipper 8c non-dipper group shows no significantly difference at stroke history, C/T ratio over 0.5 in chest X-ray, left ventrcular hypertrophy in ECG,ST-T change in ECG, proteinuria & serum creatinine level. Non-dipper group shows significantly difference to dipper group in frequency of hypertensive retinopathy and number of combined drug used subjects. Conclusion Number of hypertensive retinopathy is significantly frequency in non-dipper group. Hypertensive retinopathy is atherosclerotic complication, thus we predict other target organ damage, therefore non-dipper type circardian rhythm of blood pressure is adverse prognostic factor for target organ damage of hypertensive subjects.

      • 열대열 말라리아와 삼일열 말라리아의 복합 감염 1례

        윤광식,최창균,안병진,남홍우,정안철,이원자,이종수 대한감염학회 1998 감염 Vol.30 No.2

        최근 저자들은 파푸아뉴기니에서 20일 동안 근무하고 귀국후 발병한 열대열 말라리아를 quinine 및 doxycycline으로 치료하여 호전되었다가 다시 5개월 후와 8개월 후에 삼일열 말라리아가 발병한 혼합감염 말라리아 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. We experienced a case of mixed infection with Plasmodium falciparum and P. vivax in a 48-year old Korean man. He returned to Korea from Papua New Guinea, where he worked for 20 days. Approximately one month after return to Korea, he developed high fever and myalgia. Malaria was suspected and he was admitted to our hospital. The peripheral blood smear demonstrated ring forms of P. falciparum. He was treated with quinine and doxycycline successfully. However, fever and myalgia reappeared five months later. This time, the peripheral blood smear showed gametocytes of P. vivax, while indirect immunofluorescence antibody test revealed high titers to both P. vivax and P. falciparum. He was treated with chloroquine and primaquine. Three months later, vivax malaria recurred again; he was treated with chloroquine and higher dose of primaquine. The patient was well after 6 months of follow-up. We hereby report a case of mixed malaria infections with a review of literatures.

      • 비장-기관지 누공으로 폐렴으로 발현한 Klebsiella pneumoniae 비장농양 1예

        이승복,최창균,안병진,정안철,안명수,백재중 대한감염학회 1998 감염 Vol.30 No.3

        저자들은 Klebsiella pneumoniae에 의한 다중누공이 병발한 비장농양 1예를 경험하고 이를 경피 배농과 항균제 병합요법만으로 성공적으로 치료하였기에 문헌고찰과 함께 보고하는 바이다. Splenic abscess is an uncommon but frequently fatal condition. Signs and symptoms are variable and do not always include left upper quadrant pain or tenderness. Unexplained thrombocytosis in a septic patient with persistent left pleural effusion is suggestive of splenic abscess. We report a case of splenic abscess with complicated multiple fistulas by Klebsiella pneumoniae which was successfully managed by antibiotic therapy, and percutaneous catheter drainage.

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