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최재기,조성연,최수미,김교희,이성은,이석,김동욱,이동건 대한감염학회 2018 Infection and Chemotherapy Vol.50 No.2
Dasatinib, a tyrosine kinase inhibitor, is widely used for patients with chronic myeloid leukemia and Philadelphia chromosome- positive acute lymphoblastic leukemia. Although the drug has a potent immunosuppressive effect, infectious complications during dasatinib treatment have been reported rarely. We describe five patients who developed cytomegalovirus (CMV) colitis during dasatinib treatment, in whom the colitis was initially confused with other causes. The patients, three with chronic myeloid leukemia, and two with acute lymphoblastic leukemia, were diagnosed with CMV colitis based on endoscopic and histologic findings. The patients who examined blood CMV polymerase chain reaction were all positive. The patients received antiviral therapy in the form of either ganciclovir or valganciclovir, and the overall treatment outcome was fair. These cases suggest that physicians should consider the possibility of CMV reactivation when treating diarrhea and/or hematochezia in patients on dasatinib.
History of Syphilis and Gonorrhea in Korea
최재기,이승주,유진홍 대한감염학회 2019 Infection and Chemotherapy Vol.51 No.2
In Korea, systematic management of sexually transmitted infections (STIs), including syphilis and gonorrhea, began only after the end of the Korean War. Since the enactment of the Law on Prevention of Communicable Diseases of 1954, STI has been managed and regularly monitored in high risk group. However, the major turning point was the implementation of the Special Law on Prostitution, which was enacted in September 2004. The national policy on STI management had also changed from management of core groups by mandatory to voluntary examinations and treatment of patients by health examinations. The national surveillance system for STI was introduced in 2000 by the revision of the Prevention of Communicable Diseases Act of 1999. The incidence of STI had increased in the 1960s, but began to decline at the 1970s. In the 21st century, the incidence of STI has been increasing again. Currently, more thorough methods of STI management are needed in Korea.
자동차 엔진용 소결 밸브시트의 미세조직과 기계적 성질에 미치는 고체윤활제의 영향
최재기 한국분말야금학회 1999 한국분말재료학회지 (KPMI) Vol.6 No.2
Engine valve seat is a functionally important part for maintaining engine performance. The progress of automotive technology has increased the severity of conditions to which it is exposed, especially as regards LPG fuel engines and turbocharger. Therefore, it requires excellent heat and wear resistance to meet the severe condition inside the engine. In the present study, effects of solid lubricants such as CaF$_2$, MnS and MoS$_2$ on microstructure and mechanical properties of sintered Fe alloys for valve srats have been investigated for the development of valve seat material with high temerature wear resistance. As a results of engine simulation test, 0.5 wt% CaF$_2$ specimen showed the most excellent property, but in the overall aspect of view valve recession has increased with increasing the amount of solid lubricants.
최재기,유진홍 대한의학회 2019 Journal of Korean medical science Vol.34 No.34
Increasing antibiotic resistance to enteric gram-negative bacteria is already a global trend. Especially in Korea, community-acquired urinary tract infection caused by extended- spectrum beta-lactamase (ESBL) producing Enterobacteriaceae is very common.1 The increase in resistant bacteria leads to hesitation when choosing narrow-spectrum antibiotics as empirical antibiotics, resulting in increased frequency and amount of broad-spectrum antibiotic use in definite treatment. In particular, changes in antibiotic use in UTIs with high disease burden are expected to have a significant effect on overall antibiotic resistance. This can be shown by the correlation between antibiotic usage and antibiotic resistance in the big data study analyzing the Korean Antimicrobial Resistance Monitoring System (KARMS) data from the Korea Centers for Disease Control and Prevention (kCDC) and National Health Insurance (NHI).2 Therefore, the selection of empirical antibiotics considering increased resistance and the concern about the administration of appropriate and narrow-spectrum antibiotics in definite treatment are key questions for current UTI antimicrobial stewardship.
침습성 기관-기관지 아스페르길루스증: 증례보고 및 국내 문헌 고찰
최재기,이동건,노진희,이보희,윤재승,김시현,권재철,홍지형,이국진,박선희,최수미,최정현,유진홍 대한감염학회 2011 Infection and Chemotherapy Vol.43 No.1
Invasive tracheobronchial aspergillosis (iTBA) is an uncommon clinical manifestation of invasive aspergillosis and this is usually limited to the large airways. Its pathophysiology and clinical features are obscure, but some fatal cases of iTBA in immunocompetent patients have also been reported. We describe 4 cases of iTBA in the patients with hematologic malignancies, that was early diagnosed by bronchoscopy, a computed tomography and successfully treated by proper antifungal treatment. And we also review the cases of iTBA reported in Korea.