Radiation-Induced IL(interleukin)-6 in Mice with Algin-Oligosaccharide Treatment

Seong-Kwan Choi(최성관),Youn-Sang Ji(지연상) 대한방사선과학회(구 대한방사선기술학회) 2010 방사선기술과학 Vol.33 No.4

본 연구에서는 미역이나 다시마에 많이 분포하면서 항산화작용이 탁월한 알긴산올리고당의 방사선 방어효과를 알아보기 위해 3 Gy 방사선이 전신 1회 조사된 마우스를 가지고 IL-6을 측정하였다. 측정 결과 방사선조사대조군과 비교하여 볼 때 소장과 간 조직 모두 방사선조사 전 7일간 알긴산올리고당의 처치를 시행한 그룹에서 IL-6 생성이 억제됨을 관찰하였다(p < 0.001). 이는 알긴산올리고당이 항산화작용을 통해 방사선이 피폭된 생체조직을 방어함으로써 IL-6의 생성을 억제한 것으로 사료된다. 결론적으로, 본 연구를 통해 알긴산올리고당의 일부 방사선 방어효과를 규명했고 아울러 화학적 독성이 없는 자연산생물이 방사선 방어제로 활용될 수 있을 가능성을 확인하였다. To examine the radioprotective effect of algin-oligosaccharide(AOS), radiation-induced IL(interleukin)-6 in mice treated with 3 Gy whole body irradiation once were examined. In the measurement of irradiation-induced IL-6, in comparison with the irradiation control group, in both small intestine and liver tissues of the group treated with algin-oligosaccharide for 7 days prior to irradiation, was suppressed IL-6 synthesis(p < 0.001). It is considered that the protection against radiation hazard by antioxydative reaction of algin oligosaccharide results in down control of IL-6 value in experimental groups treated with algin-oligosaccharide. In conclusion, through our study, the fact that algin-oligosaccharide has irradiation protection effects was elucidated, and simultaneously, the possibility of the use of a natural product without chemical toxicity as an irradiation protection agent was confirmed.

CT 검사에서 대동맥박리(aortic dissection)의 발생빈도에 관한 고찰

동경래(Kyung-Rae Dong),최성관(Sung-Kwan Choi),장영일(Young-Ill Jang),노상호(Sang-Ho Ro) 대한방사선과학회(구 대한방사선기술학회) 2008 방사선기술과학 Vol.31 No.2

  목 적: 혈관의 내층과 외층을 급속히 해리시키는 예후가 매우 위험한 질환으로 대동맥 박리증(aortic dissection)의 임상적 진단을 위해 CT를 시행하여 대동맥 박리 증으로 판명된 환자 수와 연령별로 발생 빈도를 조사하고자 하였다.<BR>  방법 및 대상: 2005년 1월부터 2006년 12월까지 2년간 C대학병원에 내원한 환자 중 CT를 시행한 환자 112명을 대상으로 연도별로 증감 추세를 조사해 보고, 성별, 연령별, 진료과별로 조사 해 보았으며, 정확한 관찰을 위해 CT scan 후의 재구성 영상인 MIP와 SSD 그리고 VRT영상을 획득하여 CT와 일반 Chest PA 상을 비교하여 결과를 조사 연구하였다.<BR>  결과 및 결론:<BR>  1. CT를 시행한 환자 112명을 대상으로 연도별 검사건수는 2005년도 37명으로 41.9%를 보였고, 2006년도는 65명으로 58.1%로 2005년에 비해 2006년에 1.4배 증가되었다.<BR>  2. CT를 시행한 환자의 성별분포는 남성이 45명으로 40.1%, 여성이 67명으로 59.9%를 차지하고 있고 남성 45명 중 대동맥 박리증 환자는 9명으로 20%, 여성은 67명 중 21명으로 31.3%로 대동맥 박리증 환자가 남성에 비해 여성이 1.6배 많이 발생되었다. 또한 검사자 수도 남성에 비해 여성이 1.5배 많은 것으로 나타났다.<BR>  3. CT를 시행한 환자의 연령별 분포는 30세 미만에서는 거의 볼 수 없었으며 41세에서 80세까지가 전체에 88.3%를 차지하였으며 연령이 높을수록 대동맥 박리증 질환의 발생빈도가 높게 나타났다. 연령별 발생빈도의 차이는 통계적으로 유의하였다(p<0.01).<BR>  4. CT를 의뢰한 과는 응급의학과에서 46명(41.1%), 순환기 내과에서 37명(33.0%), 흉부외과에서 13명(11.6%), 기타 과에서 16명(14.3%)으로 응급의학과와 순환기내과가 전체의 74.1%로 나타났다. 따라서 대동맥 박리증 질환의 환자는 주로 응급실로 내원하는 매우 위험한 질환이라는 것을 알 수 있다.<BR>  5. 대동맥 박리 환자 30명 중 22명(73.3%)은 일반 X-ray상 정상으로 판독되었고, 8명(26.7%)만이 일반 X-ray상 이상소견이 나왔다. 따라서 대동맥 박리 질환을 정확히 평가하기 위해서는 반듯이 CT를 시행해야 할 것으로 사료되었다.   Purpose: Aortic Dissection is very dangerous, prognostic disease, which the bloodstream flow out of the true lumen of the aorta by the bursting of aortic intima resulting in a rapid dissociation of inner and outer layer from the media. It is difficult to diagnose aortic dissection clinically by normal X-ray. This study was to investigate the occurrence frequency by age and number of patients who are identified to be aortic dissection by CT(Computed Tomography) scan.<BR>  Materials and methods: We investigated the trend of yearly fluctuation, gender, age, and department of clinical research of the 112 patients who conducted CT scan in C- University Hospital for two years from January 2005 to December 2006. The MIP and SSD which reconstructed CT image and the VRT image were obtained for the accurate observation. The result was investigated by comparing normal X-ray and CT scan.<BR>  Results and Conclusion:<BR>  1. The yearly check of 112 patients conducted CT scan showed 37 people(41.9%) in 2005, and it was increased to 65(58.1%) in 2006 by 1.4 times.<BR>  2. The gender distribution of patients given a CT scan showed 45 males(40.1%), and female 67(59.9 %). The aortic dissection patients were 9(20%) out of 45 males, 21(31.3%) out of 67 females and women were 1.6 times more than men. Women are also 1.5 times more than men in the number of examinee.<BR>  3. The age distribution of patient"s who conducted CT scan revealed that there was no patient under 30 years old while 88.3% of all patients were through 41 to 80 years old. The higher the age was, the higher the occurrence of aortic dissection was. The difference in the occurrence frequency of age was statistically significant(p<0.01).<BR>  4. The departments that requested CT scan were the emergency department 46(41.1%), circulatory internal medicine 37(33.0%), chest surgery 13(11.6%), and others 6(14.3%). The combined ratio of emergency medicine and circulatory internal medicine was 74.1% of all. The results show that the aortic dissection is a very dangerous disease whose patients visit mainly via the emergency room.<BR>  5. The aortic dissection patients had normal X-ray readings in 22(73.3%) out of 30, and only 8(26.7 percent) are abnormal in the X-ray diagnosis. Therefore, the CT scan needs to be enforced in order to assess accurately the disease of aortic dissection.

정상 영아에서 발생한 대상포진

나건연 ( Gun Yoen Na ),최성관 ( Sung Kwan Choi ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.3

Herpes zoster in infancy occurs very rarely. And it may be the primary clinical manifestation of reactivation of latent varicella-zoster virus infection acquired transplacentally during intrauterine life. We report a case of herpes zoster in right T2 dermatome in a normal 3-month-old boy, The patient had no history of chickenpox and varicella vaccination. And his mother did not recall herself varicella infection, though she was exposured to chickenpox patient at 7 months of pregnancy. Laboratory findings demonstrated that varicella-zoster Ig-G and Ig-M antibodies were 0.94, 0.12 respectively ( EIA method, negative, <0.8; positive, >1.0) at the second day of vesicular eruption. Fourteen days after vesicular developing, the Ig-G and Ig M titers were rising to 1.92, and 0.47 respectively. His mother's varicella-zoster Ig-G and Ig-M antihodies were 2.64, 0.14 respectively. The baby received acyclovir treatment and the skin lesions healed rapidly without sequela. In this case, although the cause was unclear whether it was a mother-child infection, the patient was suspected subclinical intrauterine varicella-zoster virus infection during pregnancy. (Kor J Dermatol 1996;34(3) 476-479)

두피의 지루피부염에 대한 임상적 관찰과 Pityrosporum의 분포

백승혜,정상립,김도원,정현주,최성관 ( Seung Hye Paek,Sang Lip Chung,Do Won Kim,Hyeon Joo Jung,Sung Kwan Choi ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.1

Background: Seborrheic dermatitis is a very common chronic inflammatory disease. Previous studies suggested that, Pityrosporum, lipophilic fungi, may play an important role in the pathogenesis of the disease. Objective : The purpose of this study was to investigate the disease clinically and mycologically for better understanding of the pathogenesis. Methods : Two hundred and one new patient.s with seborrheic dermatitis of the scalp and 67 norrnal subjects were obs!,rved clinically by the dermatologist and studied stat,istically by questionnaires. A mycologic study of Pityrosporum was also performed by direct smear. Results : Among a total of 201 patients wit,h seborrheic dermatitis, 72.6% had pityriasis sicca, 10.5% had pityr iasis steartoides and 16.9% had inflammatory seborrheic dermatitis. On clinical grading by the Kligman.. scale, grade III(slightly scaling) was the most common in the patients and 52.6% of the norma. subjects were below grade II (no scaling). Spores of Pityrosporum were observed in 76.7% of the patients and 91.5% of the normal subjects. The incidence of Pityrosporum was lower particularly in t,he patients with inflammatory seborrheic dermatitis t,han in other pa~tients groups. Conclusion : According to the results of the study, it, is difficult to conclude that Pityrosporum is a main causative ager t of seborrheic dermatitis. In addition, it is thought t.hat further studies of the role of Pityrosporum in seborrheic dermatitis are needed. (Kor J Dermatol 1997;35(1): 22-32)

호산구성 농포성 모낭염 2예

최인철(In Chul Choi),최성관(Sung Kwan Choi),정상립(Sang Lip Chung),김성화(Sung Hwa Kim) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.3

We report 2 cases of eosinophilic pustular folliculitis, one in s 29-year-old woman and the other in a 24-year-old man. Crops of papules and pustules developed on well demarcated, walnut-sized, erythematous plsques on the cheeks and forehead. Eruptions were more pronounced on the periphery of the plaques with central clearing. Blood eosinophilia was evident in case 1. Histologic findings showed a dense inflammatory infiltration and abscesses composed mainly of eosinophils in and around hair follicles, sebaceous glands and around blood vessels. We could see beneficial responses by administration of dapsone in both cases, but its effect was just suppressive and temporary.

The Study on the Attenuation of X-ray and Imaging Quality by Contents in Stomach

Kyung-Rae Dong(동경래) · Youn-Sang Ji(지연상) · Chang-Bok Kim(김창복) · Seong-Kwan Choi(최성관) · Sang-In Moon(문상인) · Kevin Dieter(디터 케빈) 대한방사선과학회(구 대한방사선기술학회) 2009 방사선기술과학 Vol.32 No.1

인체의 40~50%인 연부조직에 X선을 조사하면 연부조직의 두께에 따라 투과선량이 감소하며 영상에도 질적 저하를 가져온다. 본 연구는 복부 촬영시 위장내 내용물에 따라 X선 감약 및 화질에 차이가 나타날 수 있다는 가정 하에 실제 위의 조직과 비슷한 조직등가물질 phantom을 제작하여 실제 위장내 내용물에 따른 X선의 감약 변화와 DR (Digital Ridiography)의 ROI수치를 비교해보았다. 단백질 두께가 증가할수록 X-선 감약에 의한 투과선량이 감소되었으며(p < 0.001), Film과 DR 영상에서의 ROI Mean값의 변화도 감소하였다(p < 0.001). Film과 DR 영상에서의 ROI Mean값에 대한 비교는 Film이 DR 영상에 비해 단백질 두께에 따른 농도의 변화 값이 크게 나타났다(p < 0.001). 이와 같은 결과를 종합해 볼 때 DR system 촬영 보다는 필름을 사용하는 단순촬영에서 금식(NPO ; nothing by mouth)의 필요성이 더 중요함을 알 수 있다. This study examined the change in the attenuation of X-rays with the ROI (Region of Interest) in DR (Digital Radiography) according to the stomach contents by manufacturing a tissue equivalent material phantom to simulate real stomach tissue based on the assumption that there is some attenuation of X-rays and a difference in imaging quality according to the stomach contents. The transit dosage by the attenuation of X-rays decreased with increasing protein thickness, which altered the average ROI values in the film and DR images. A comparison of the change in average ROI values of the film and DR image showed that the image in film caused larger density changes with varying thickness of protein than the image by DR. The results indicate that NPO (nothing by mouth) is more important in film system than in DR system.

소아 족부 및 수부백선에 관한 고찰

서무규(Moo Kyu Suh),성열오(Yeol Oh Sung),오수희(Soo Hee Oh),김성화(Sung Hwa Kim),최성관(Sung Kwan Choi),서순봉(Soon Bong Suh) 대한피부과학회 1993 大韓皮膚科學會誌 Vol.31 No.5

Background : Because of concern about the infrequent occurre icc of tinea pedis & tinea manus, we studied the incidence of them. Objective : The purpose of the study was to investigate clinical and mycological features of tinea pedis & tinea manus. Methods . We reviewed outpatients with tinea pedis & tinea minus at the Catholic Skin Disease Clinic from 1976 to 1991. Results : The incidence was 0.08% out of 1,106,246 outpatients in tinea pedis, 0.02% in tinea manus. Interdigital lesions were the most common in tinea pedis. The ratio of male to female patients was 1.46: 1 in tinea pedis, 1.34:1 in tinea manus. The seasonaI pevalance was highest in summer. The species isolated were, in order of decreasing frequency, Trihohyton(T.) rubrum(89.9%), T. mentagrophytes(8.5%), Microgorum(M.) canis (1.6%) in tinea pedis, T. rubrum(77.8%), T. mentagrophytes(18.2%), M. Canis(2.0%), Epidermophyton(E.) floccosam(2.0% in tinea manus. Conclusion : We find that, the incidence of tinea pedis has been inc easing in recent years. (Kor J Dermatol 1993;31(5):713-720)

왕우렁이(Ampullarius Insulanes) 의 섭식(攝食)ㆍ생태(生態) 및 논잡초 방제(防除) 효과(效果)에 관한 연구(硏究)

정순재 ( Jeong Soon-jae ),박홍식 ( Park Heung-sik ),오주성 ( Oh Ju-sung ),최봉출 ( Choi Bong-chool ),최성관 ( Choi Sung-kwan ) 한국유기농업학회 1999 韓國有機農業學會誌 Vol.7 No.2

This experiment were performed on rice dignity during 1998 at paddy field of Dong-a Univ., Pusan, Korea. Depression effect of weed occurrence by pasture of 2kg of the Ampullarius insularus per 10a was 80.4% at the 7th day after transplanting, 69.7% at the 14th day after transplanting pasture plot and 51.8% at the 21th day after transplanting. Depression effect of weed occurrence by pasture of 5kg of the Ampullarius insularus per 10a was 97.9% at the 7th day after transplanting, 79.2% at the 14th day after transplanting pasture plot and 64.1% at the 21th day after transplanting. Depression effect of weed occurrence by pasture of 8kg of the Ampulbrius insularus per 10a was 97.9% at the 7th day after transplanting, 87.1% at the 14th day after transplanting pasture plot and 71.4% at the 21th day after transplanting. Weeds ingestied by the Ampullarius insularus were in the order of perennial weed, annual weed.

Drechslera dematioidea에 의한 Primary Subcutaneous Phaeohyphomycosis

오수희 ( Kosuke Takatori ),서순봉 ( Soo Hee Oh ),김성화 ( Soon Bong Suh ),최성관 ( Sung Hwa Kim ),이헌준 ( Sung Kwan Choi ),( Hun Jun Lee ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.3

Phaeohyphomycosis refers to subcutaneous and systemic fungal infections characterized by dematiacious septate mycerial elements in tissue, We are discribing the first report of subcutaneous phaeohyphomycosis by Drechslera dematioidea in a 9-year-old boy who presented a slow-growing 4 * 5.5cm erythematous plaque with somewhat verrucous and eczematous lesion on the dorsal aspect of his right foot after receiving a burn by boiling liquid at 2 years of age. Biopsy of the lesion revealed granulomatous inflammation, brownish spores in chain and planate-deviding sclerotic bodies in the epidermis and upper dermis. Findings by microscopic examination and consecutive cultures of scales and biopsy specimen were consistent with Drechslera dematioidea. The lesion was successfully treated with itraconazole. (Kor J Dermetol 1996;34(3): 489-494)

지속적 농업발전을 위한 유기농업전략

박흥식,정순재,오주성,최성관 東亞大學校 大學院 1999 大學院論文集 Vol.24 No.-

The economic impact on the environment and human health caused by conventional chemical intensive agriculture is causing scientist to re-assess the development of agricultural systems. Pesticides and processed chemical fertilizers have been shown to becausing environmental disruption which will nudermine the resource base on which agriculture production depends. The rise of sustainale agriculture, integrated pest management, organic agriculture, and other forms of alternative agriculture are a result of varmers and researchers searching for new solutions to the problem of food production which does not endanger the all important agriculture are a result of farmers and researchers endanger the all important agriculture resource base. Organic agriculture is one approach which has been developing more quickly in recent years with increasing consumer purchasing power. Organic agriculture has shown itself to be sa or more profitable, and in many cases as productive as conventional agricultural methods on some crops. Further development of organic agriculture, and low-input agriculture will require further modification of policies which overwhelmingly support high imput, chemical intensive agriculture.