Cytotoxic Activities of Diarylheptanoids from Alnus japonica

최선은,김광호,김승범,김하원,권주희,이민원 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.10

The diarylheptanoids (1-10) 1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-O-β-D-glucopyranosyl(1→3)-β- D-xylopyranoside (1), 1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-O-β-D-apiofuranosyl(1→6)-β-D-glucopyranoside (2), 1,7-bis-(3,4-dihydroxyphenyl)-heptane-5-O-β-D-glucopyranoside (3), 1,7-bis-(3,4- dihydroxyphenyl)-5-hydroxyheptane (4), 1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-one-5-O-β-D-glucopyranoside (5), oregonin (6), hirsutanonol (7), hirsutenone (8), 1,7-bis-(3,4-dihydroxyphenyl)-5- hydroxyheptane-3-O-β-D-xylopyranoside (9), and platyphylloside (10), isolated from the bark of Alnus japonica, were analyzed for their cytotoxic activities on various human and mouse cancer cell lines. The cytotoxic activities of these ten compounds were evaluated against murine B16 melanoma, human SNU- 1 gastric cancer, human SNU-354 hepatoma cancer and human SNU-C4 colorectal cell lines. The diarylheptanoids showed potent cytotoxic activities against murine B16 melanoma cells and human SNUC1 astric cancer cell when the cell viability was analyzed by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazoliumbromide) assay.

회화나무 열매의 고지혈증 개선 효능

최선은,심재걸,오명환,권석형,이민원 한국생약학회 2009 생약학회지 Vol.40 No.3

Anti-hyperlipidemic effect of Sophorae Fructus in male Spague-Dawley rats induced by high-rich diet were studied. Oral administration of Sophorae Fructus extract significantly decreased serum total cholesterol (TC), LDL-cholesterol, triglyceride (TG), GOT and GPT levels, and incresed serum HDL-cholesterol level and also decreased the level of liver TC, TG, GOT and GPT. These results suggest that Sophorae Fructus extract is effective for the hyperlipidemia.

|특집| 산림자원 활용 바이오소재 개발 최신 동향 강원도 차나무 산업 발전을 위한 한국형 홍차의 품질 기준 재정립 필요성에 대한 연구동향

최선은 춘천바이오산업진흥원 2021 CBF 바이오경제 이슈포커스 Vol.2021 No.9

신나무 수피로부터 Gallotannin 화합물의 항산화 활성 및 함량분석

최선은,박관희,오명환,장준혜,진혜영,김성식,이민원 한국생약학회 2010 생약학회지 Vol.41 No.3

− Activity guided isolation of 80% acetone extract from the barks of Acer ginnala Maxim. yielded five gallotannins [6-galloyl-1,5-anhydroglucitol (ginnalin B) (1), acertannin (3,6-digalloyl-1,5-anhydroglucitol) (2), methyl gallate (3), acertannin (2,6-digalloyl-1,5-anhydroglucitol) (4) and gallic acid (5)]. All of these isolated compounds from Acer ginnala(1-5) were firstly isolated from Acer ginnala Maxim. And contents of compounds from barks of Acer ginnala (Comp. 1: 0.73±0.002%, Comp. 2: 0.48±0.001%, Comp. 3: 0.66±0.002%, Comp. 4: 1.05±0.002% and Comp. 5: 0.29±0.001%) were evaluated by HPLC analysis. And, in order to evaluate anti-oxidative activities on Comp. 1-5 isolated from Acer ginnala, DPPH radical scavenging activity was measured in vitro. All of these isolated compounds from Acer ginnala exhibited potent DPPH radical scavenging activities.

한국과 일본 전통복식의 미적 특성 비교-조선후기와 에도(江戶)시대 복식을 중심으로-

최선은 한국동양예술학회 2002 동양예술 Vol.6 No.-

동북아시아의 문화 흐름은 중국대륙에서 한반도를 거쳐 일본으로 가서 정착 형성되었다. 그런데 우리나라는 중국의 의복제도를 일본에 그대로 전해주지 않았고, 일본 역시 그대로 답습하지는 않았으므로 한·일 전통복식에서는 유사성과 함께 민족고유의 미적감각이 표현된 독자성이 나타난다. 본 연구에서는 조선후기와 일본 에도시대의 전통복식에 나타나는 외형적요소를 바탕으로 하여 미적 특성을 비교하였다. 조선후기와 에도시대 전통복식의 양식이 형성되는 과정에는 당시의 사회상을 잘 반영하고 있다는 점에서 유사성을 보인다. 이러한 사회 문화적 배경의 전제하에 양국 전통복식의 미적 특성을 비교한 결과, 조선복식에는 공통적으로 조선사회 전반을 지배한 미적 가치관인 유교적 관념에 따른 예의관이 포함된 격식의 미와 은폐의 미를 외형적 요소 각 부분에 상징적으로 내포하고 있었다. 이렇게 사상적, 종교적 관념에 기반을 둔 조선후기의 전통복식에 표현된 미의식에 비하여 에도 복식에는 비종교적이며, 현세적 특성이 미의식에 강하게 반영되어 있다. 에도 복식의 가장 두드러진 미적 특성은 武家사회의 권위를 표현하고, 왜소한 체형을 크게 보이기 위한 과장의 미와, 겹쳐 입는 특성에서 비롯된 襲色의 미가 두드러지게 나타난다. 이것은 에도 문화의 민중적이면서도 향락적인 성향을 동시에 반영하며, 현대 일본 전통복식인 和服(와후꾸기모노)에 나타나는 미의식과도 연결된다. 이처럼 양국 민족 고유의 전통복식에 표현된 미의식에는 유사성보다는 독자성이 두드러짐을 유추해낼 수 있다.

너, 당산나무여

최선화(崔先華) 샘터사 1992 월간 샘터 Vol.23 No.8

중국 파견학생 문화역량 향상을 위한 교육방안 제시

최선진(Choi, Seon-Jin)(崔善珍) 대한중국학회 2019 중국학 Vol.68 No.-

국제화 시대에 따라 해외 파견 유학생이 많아지고 있으며, 각 대학에서도 교환학생 프로그램이 활발히 진행되고 있다. 이와 함께 해외 교류에 필요한 문화역량에 대한 관심도 커지고 있다. 해외 한국인 유학생 현황에 따르면 중국지역 유학생 수가 가장 많은 비율을 차지하고 있는 데 반해, 이에 대한 전문적인 조사나 연구가 거의 없다. 따라서 본 연구는 중국지역 교환 프로그램을 통한 문화역량 변화와 교환 전과 과정 중의 요인에 대한 문화역량의 관계를 조사·분석해 보았다는 데 의의가 있다. 이를 조사하기 위해 A 대학 중국학부 학생 중 2016년부터 2018년까지 중국지역으로 파견 간 교환학생을 대상으로 교환 전과 후 2차례에 걸쳐 설문조사를 시행하였고, 2차례 설문에 모두 참여한 동일 집단 53명을 연구대상 범위로 정하였다. 통계 결과와 주관식 의견을 토대로 교환학생 프로그램에 대한 문제점과 개선해야 할 부분을 파악하여 3가지 교육방안을 다음과 같이 제시하였다. 1)교환학생 선발방법 변경 또는 추가 조건제시, 2)기 경험자가 참여하는 정보망 구축, 3)교환 전 교내에서부터 현지인과의 교류를 적극적으로 지원 하자이다. 본 연구의 제시방안을 활용하여 중국지역 파견뿐만 아니라 해외 교류 프로그램의 양적 성장과 질적 성장이 함께 이루어지길 바란다. With the advent of globalization, each universities actively run a student exchange program. In addition, there is a growing interest in cultural competency for international exchanges. These days, more and more Korean students are going to China to study its language and culture but no research has been conducted to make better programs or systems for students. Therefore, this study is meaningful to identify changes of cultural capacity through the exchange program in China. For research, the survey was conducted in A university’s Chinese studies students who participate in exchange student program in China from 2016 to 2018. A group of 53 students responded survey on two separate occasions. Based on the statistical results and opinions on the subject matter, researcher identified the problems of current exchange student program, the way for further improvements and three options for educational methods. 1) Changing the method of selecting exchange students or suggesting additional conditions, 2) Establishing an information network with prior experience in exchange student, 3) Supporting various interacting programs with natives inside a college before exchanging.

물오리나무 유래 고함량 Oregonin 추출방법 및 생리활성 연구

최선은 한국생약학회 2019 생약학회지 Vol.50 No.3

Oregonin is known as a representative active substance of plants of the Alnus species. In this study, we will show the results of establishing a method for extracting trace amounts of useful substances in plants. Additionally, a variety of physiological activity studies were conducted with extracts containing high content of useful substances. In this study, anti-oxidant, anti-inflammatory and anti-allergic activities of supercritical fluid residue 60% EtOH extracts of Alnus sibirica (ASCFR) were investigated in vitro. To explore anti-oxidant and anti-inflammatory characteristics of supercritical extract, DPPH radical scavenging, and ABTS radical scavenging activity, inhibition of nitric oxide production in LPS-stimulated RAW 264.7 cells and β-hexosaminidase release in IgE-stimulated RBL-2H3 cells were examined, respectively. Results showed a concentration-dependent increase in DPPH and ABTS radical scavenging activity. Cells stimulated with LPS produced more nitric oxide than normal control cells. However, cells treated with supercritical fluid residue 60% EtOH extract decreased production in a concentration-dependent manner. In anti-allergic activity studies, ASCFR showed concentration-dependentanti-allergic activity. Based on results and strong antioxidant activity, ASCFR has potential as basic research materials for development of therapeutic supplements-based medicines or functional cosmetics related to chronic inflammatory skin immunity diseases.

여행가방을 챙기듯

최선열(崔善烈) 샘터사 1991 월간 샘터 Vol.22 No.5

학령기 아동의 가족환경 건강문제 및 건강위험행위 간의 관계

최선하(Sun-Ha Choi),손민(Min Sohn),안영미(Young-Mee Ahn) 한국생활환경학회 2011 한국생활환경학회지 Vol.18 No.5

This is a cross sectional descriptive study to explore family environment (family structure and family function) health problems and health risk behaviors and to determine the relationships among them in school aged children. A structured questionnaire was used to collect the data from children in four elementary schools and their parents. The data of 1,882 children and same number of their parents were included in data analysis. The majority of their family type was a nuclear family (79.7%); 71% of fathers and 28% of mothers were regularly employed; parents were well educated; and the average number of householder was four. Their mean Family APGAR score was 7.4 (±2.04) which refers highly functional families. In children 32% had any kind of health problems and the most common health problem was atophy/allergy (15.7%). Their most common health risk behavior was alcohol drinking (42%) followed by being attacked with sexual verbalism (32.2%). Being highly functional family was associated with a nuclear family (F=5.750 p<.001) having regularly employed fathers (F=54.306 p<.001) not employed mothers (F=13.191 p<.001) well educated parents (father F=55.970 p<.001; mother F=55.103 p<.001) and absence of children's health problems (t= 7.753 p=.005). Trying health risk behaviors seems associated with lower Family APGAR score but the results were not statistically significant. In conclusion family environment health problems and health risk behaviors in school age children were all associated with each other. It is highly recommended to consider family environment to assess and intervene health problems and health risk behaviors in school age children.