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주원덕(Won Duk Joo),김미경(Mi Kyung Kim),이성원(Sung Won Lee),최경찬(Kyung Chan Choi),이동헌(Dong Hun Lee),김종혁(Jong Hyeok Kim),김용만(Yong Man Kim),김영탁(Young Tak Kim),목정은(Jung Eun Mok),남주현(Joo Hyun Nam) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.10
We report a case of squamous cell carcinoma of Bartholin`s gland for the first time in Korea. The patient had diagnosed unexpectedly by an incidental Rt. Bartholin`s cystectomy at Chunchon Sacred Heart Hospital. She was transferred to Asan Medical Center and performed Rt. hemivulvectomy with ipsilateral inguinal-femoral lymph node dissection for staging. She was FIGO stage Ⅱ (T2N0M0) and has been followed up for 9 months without any evidence of recurrence. Squamous cell carcinoma of Bartholin`s gland is very rare among the female genital malignancies. The treatment of this malignancy is not established yet. So it should be individualized to the patient by the resectability and the status of resection margin involvement.
김인철,신대원,최용재,배은주,이경자,류병윤,조지웅,최경찬,Kim, In-Cheol,Shin, Dae-Won,Choi, Yong-Jae,Bae, En-Joo,Lee, Kyeung-Ja,Ryu, Boung-Yoon,Cho, Ji-Woong,Choi, Kyung-Chan 대한소아소화기영양학회 2001 Pediatric gastroenterology, hepatology & nutrition Vol.4 No.1
저자들은 5개월 된 남아에게 장중첩증 원인으로 흔하지 않은 게실로 판명되었던 1례를 치험하여 문헌 고찰과 함께 보고하는 바이다. Intussusception is a frequent cause of bowel obstruction in the first five years of life and it is one of the most common surgical emergencies in infancy and early childhood. The age of five months child was administered in Department of Pediatrics of Chunchon Sacred Heart Hospital. His main symptoms were vomiting and high fever for three days. Abdominal sonography, air reduction and abdominal computerized tomography (CT) were performed and the conclusion of these study was intussusception due to cyst mass lesion; duplication cyst, mesenteric cyst or Meckel's diverticulum. He was transferred for operation. We had performed laparotomy for reduction of the intussusception. Operative findings revealed ileocolic type of intussusception due to cystic tumor on ileocecal valve that was invaginated into the cecum, and hyperplasia of the Peyer's patch were seen. But we failed manual reduction because of the tumor in the ileocecal area. So we had performed partial resection of the ileocecum. Diverticulum of the ileum was confirmed by pathologic examination. We experienced unusual cause of the intussusception. So we report this case with a review of the literatures.
모아진 ( A Jin Mo ),성지은 ( Ji Eun Sung ),경민선 ( Min Sun Kyung ),조용 ( Yong Cho ),노의선 ( Eu Sun Ro ),최경찬 ( Kyung Chan Choi ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.9
뮐러씨선육종은 양성으로 증식하는 선조직과 육종성 기질조직이 혼재해 있는, 악성 혼합 뮐러씨종양의 드문 변종이다. 이 드문 종양에 대한 기본적인 치료는 양측 난소, 난관을 포함하여 전자궁절제술이다. 예후는 비교적 좋지 않으나, 악성 혼합 뮐러씨종양보다는 좋다. 수술 후 보조적인 방사선 요법 및 항암요법에 대한 효과는 논란이 많으며, 확실하지 않다. 저자들은 질초음파검사에서 포상기태와 비슷한 양상을 보이고, 자궁내막 조직검사에서 선섬유종의 소견을 보인 62세의 여성에서, 자궁 및 양측 난소-난관절제술후에 뮐러씨선육종으로 확진 된 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Mullerian adenosarcoma which is characterized by admixture of benign-appearing neoplastic glands and sarcomatous stroma, is an uncommon variant of malignant mixed mullerian tumor (MMMT), Classic treatment for this rare tumor is hysterectomy with bilateral salpingo-oophorectomy. Its prognosis is relatively poor, but better than MMMT, The efficacy of adjuvant postoperative radiotherapy and chemotherapy is debatable and appears not to be promising. We report a 62-year-old female with mullerian adenosarcoma diagnosed after hysterectomy with bilateral salpingo-oophorectomy, which had shown unique ultrasonographic feature like hydatidiform mole and had been diagnosed as fibroadenoma in endometrial curettage, with brief review of literatures.
김종철(Jong Chul Kim),이동욱(Dong Wook Lee),이윤혁(Yoon Hyuk Lee),이성원(Sung Won Lee),조용(Yong Cho),노의선(Eu Sun Ro),최경찬(Kyung Chan Choi),박영의(Young Euy Park) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.8
Sclerosing stromal tumor, which was first described by Chalvardjian and Scully in 1973, is a very rare benign tumor of the ovary. This tumor differs from the fibroma, thecoma and lipoid cell tumor clinically and pathologically by showing prominent pseudolobular pattern and hypervascularity. We experienced a case of sclerosing stromal tumor of the ovary in 38 year-old woman. We report this case with a brief review of the literature.
간세포암에서 현미부수체 불안정성과 p53 유전자 이형접합 소실
김준석(Jun Seok Kim),임만섭(Man Sup Lim),김두진(Doo Jin Kim),김주섭(Joo Seop Kim),김관석(Kwan Seok Kim),김홍기(Hong Ki Kim),조성진(Seong Jin Cho),권미정(Mi Jung Kwon),남은숙(Eun Sook Nam),최경찬(Kyung Chan Choi),신형식(Hyung Sik Shin 한국간담췌외과학회 2009 한국간담췌외과학회지 Vol.13 No.3
Purpose : Hepatocellular carcinoma (HCC) shows various molecular and genetic alterations in its development and progression. Recently, microsatelite instability (MSI) and the loss of heterozygosity (LOH), have been postulated as useful prognostic factors in many malignant tumors. LOH is related to the allelic loss of various tumor suppressor genes, however, MSI has been found to be the result of a mismatched DNA pairing. Our objectives were to evaluate MSI and p53 gene LOH and to correlate this to clinicopathological factors. Methods : MSI analysis was performed by using polymerase chain reaction with 5 microsatellite markers (BAT25, BAT26, D2S123, D5S346 and D17S250 recommended in the 1998 NCI International Workshop) on 50 surgically resected tumors. p53 LOH was detected with 4 markers(D17S796, TP53, D17S5, D17S513). Results : MSI and p53 LOH were detected in 30% and 66%, respectively. 18% of HCCs exhibited MSI in 5 NCI-recommended markers and 18% of HCCs demonstrated MSI in 4 p53 markers. MSI was mostly detected in BAT25 and BAT26 markers. MSI was more frequently detected in tumor grade Ⅰ, small HCC, and non-lymphovascular group. For the most aprt, p53 LOH was detected by D17S513 marker(38.1%). p53 LOH results were correlated with higher tumor grade and invasiveness. LOH-High group showed a significant correlation with advanced HCCs and lymphovascular invasion. There was no demonstrated correlation between MSI and p53 LOH was not demonstrated. Conclusion : These results suggest that MSI may be involved to some extent in hepatocarcinogenesis and tumor invasion. Also MSI and p53 gene LOH may be a useful clinical indicator in determining the prognosis among patients with HCC.
최영희,박영의,김상동,최경찬,구대원,석상미 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.12
Merkel cell carcinoma is an uncommon malignancy originally called $quot;trabecular carcinoma$quot; by Toker in 1972. Although the exact origin of the Merkel cell is unknown, it probably arises from neuroendocrine cell of the basal epidermis. It then grows vertically into the dermis and subcutaneous tissue. The tumor usually affects older persons, with a median age at presentation of 66 years. Although its cause is unknown, its propensity to occur on the head, neck, or extremities suggests that sun exposure may play a role. We report a case of a 58-year-old woman who showed a solitary dusky red-colored tumor on the right upper arm. The tumor had rapidly grown since 2 months ago but there was no evidence of regional lymph node and distant metastases. Microscopically, the tumor cells were uniform with round to oval shaped nucleus and scanty cytoplasm, and showed trabecular, anastomosing cord-like arrangement mainly in the dermis and subcutaneous tissue. Ultrastructually, membrane-bound neurosecretory granules were found in the cytoplasm and characteristic perinuclear filaments were retained in each tumor cell. We performed wide local excision with 3cm margin and prophylactic radiation therapy.