천골부에 발생한 압박궤양에서 발생한 상피세포암의 치험례

천지선,양정열,Cheon, Ji-Seon,Yang, Jeong-Yeol 대한미세수술학회 2006 Archives of reconstructive microsurgery Vol.15 No.2

Malignancy in a chronic pressure sore is rare among Marjolin's ulcers. Carcinomas arising in pressure sores are highly aggressive and usually fatal. Although carcinomas in pressure sores are generally well-differentiated squamous carcinomas, they can show quite an aggressive course and do not respond either to chemotherapy or radiotherapy. The mortality rate is high despite wide surgical resection. Extensive surgical excisions with wide surgical margins are necessary and elective lymph node dissection should be considered for optimal therapy. We report a squamous carcinoma arising in a pressure sore. The related literature was reviewed.

유가의 "가"에 대한 소고 -『논어』와 『맹자』를 중심으로-

천지선 ( Cheon Ji Seon ) 서울대학교 철학과 2003 哲學論究 Vol.31 No.-

측두두정근막과 견갑부근막 유리피판의 조직학적 및 임상적 고찰

강양수,천지선,나영천,이명주,양정열,이창근,Kang, Yang Soo,Cheon, Ji Seon,Na, Young Cheon,Lee, Myung Ju,Yang, Jeong Yeol,Lee, Chang Keun 대한미세수술학회 2000 Archives of reconstructive microsurgery Vol.9 No.2

Fascia and fasciocutaneous free flaps (using perforators) are adequate reconstructive options with aesthetic and functional advantages, particularly for reconstruction of variable soft tissue defects of the extremities. Although various donor sites have been used for these concerns including temporoparietal fascia, serratus fascia, scapular fascia, fascial component of lateral arm and posterior calf fascia. The authors used temporoparietal and scapular fascia as a free flap for coverage of soft tissue defects and we compare two flap mainly their histologic studies and clinical applications. In our expierience both fascia provide thin, pliable coverage for exposed bone and tendons and provide good postoperative functional restoration on the recipient area. Histologically temporoparietal fascia flap has more rich blood supply and scapular fascia flap is rich in adipose tissue in their composition. In donor site morbidity, both flaps can bring satisfactory results about the donor sites, but the donor site of the temporoparietal fascia flap sometimes revealed conspicious linear scar and transient alopecia in short-haired patients and the scapular fascia flap has a tendency to be wider and thicker in obese patients. After successful application of the both fascia flap as a free flap in 38 patients (25 temporoparietal fascia, 13 scapular fascia) since 1995 ; authors recommend using the temporoparietal fascia flap for women, who tend to have more fat and longer hair, and the scapular fascia flap for men, who tend to be leand & shorter hair.

하안검 성형수술 후 발생한 양측 안구 뒤 혈종의 치험례

손경민,박철우,천지선,Son, Kyung Min,Park, Cheol Woo,Cheon, Ji Seon 대한두개안면성형외과학회 2013 Archives of Craniofacial Surgery Vol.14 No.2

Retrobulbar hemorrhage is a rare but serious complication after blepharoplasty, mid-face injury, and treatment of facial bone fractures. The incidence of postoperative retrobulbar hemorrhage is 0.055% with an incidence of associated permanent blindness of 0.005%. A 69-year-old male came to the emergency room with pain on both orbital areas and uncontrolled bleeding after cosmetic lower blepharoplasty performed at a private clinic. He had not been evaluated preoperatively by the private clinic, but we found that he had undergone percutaneous transluminal coronary angioplasty and taken anticoagulants for 10 years. We performed an emergency operation to evacuate the hematoma. However, after surgery, he persistently complained of orbital pain, pressure and diminished visual acuity. Intraocular pressure was increased, and computed tomography demonstrated a retrobulbar hemorrhage with globe displacement. Emergent lateral canthotomy and cantholysis were performed. Intraocular pressure was decreased to 48/30 mm Hg immediately after the operation, falling within the normal range the next day. We recommend three points to minimize loss of vision by retrobulbar hematoma. Firstly, careful preoperative evaluation must be conducted including current medications, underlying diseases and previous history of surgeries. Secondly, cautious postoperative observation is important for the early diagnosis of retrobulbar hematoma. Lastly, immediate treatment is crucial to prevent permanent blindness.

Fournier 괴사 환자의 연부조직 결손 재건술

서성보,강양수,천지선,양정열,Seo, Sung-Bo,Kang, Yang-Soo,Cheon, Ji-Seon,Yang, Jeong-Yeol 대한미세수술학회 2003 Archives of reconstructive microsurgery Vol.12 No.1

Fournier's gangrene is a synergistic necrotizing fasciitis of the perineal, perirectal and urogenital area and can be fatal unless treated in early stage. Perianal and urogenital infections are common causes of the disease but it can occur after artificial procedure on perineal area using by surgical instruments. It is mixed aerobic and anaerobic infection and E. coli is the most common causative bacteria. Untill now many investigators have focused on early diagnosis, preserving hemodynamic stability, broad-spectrum systemic antibiotics and treatment of underlying disease in management of Fournier's gangrene. The authors have experienced five patients of chronic liver disease whose necrotizing perineal infections developed spontaneously and treated them aggressively as described above and reconstructed perineal soft tissue defects using by various surgical methods, then we got good results both functionary and cosmetically. From now on, we would better reconstruct soft tissue defect of perineum with skin graft or pedicled flap in early stage when treat Fournier's gangrene, thereafter we can get an ultimate increase in patient's life quality.

안와 파열골절 후 발생한 중증 안검하수의 치료

김남훈,양정열,문재원,김규보,천지선,Kim, Nam-Hun,Yang, Jeong-Yeol,Moon, Jae-Won,Kim, Gyu-Bo,Cheon, Ji-Seon 대한성형외과학회 2010 Archives of Plastic Surgery Vol.37 No.4

Purpose: Blepharoptosis can result from either congenital or acquired causes. Blow out fracture or facial bone fracture including blow out fracture can be one of the causes. Authors experienced 3 cases of severe blepharoptosis after blow out fracture treated only with observation after reduction of associated fracture. Methods: Reconstruction of orbital wall was conducted on all cases diagnosed as blow out fracture using 3 dimensional computed tomography, and conservative treatment was done on accompanying severe blepharoptosis. Results: At the time of injury, all cases showed severe blepharoptosis requiring frontalis muscle transfer for correction. But blepharoptosis was recovered in an average of 18 weeks without any surgical procedure except reconstruction of orbital wall. Conclusion: Once Blepharoptosis occurred after blow out fracture, thorough evaluation must be done at first. If definitive cause of blepahroptisis cannot be found as authors' cases, injury of oculomotor nerve may result in blepharoptosis. So, as for blepharoptosis after blow out fracture, conservative treatment following reconstruction of fractured orbital wall can be one of good management.

안면골 골절 환자에 대한 표준진료지침 개발에 따른 환자의 인식도 증가와 만족도 개선 효과

최우영,박철우,손경민,천지선,Choi, Woo Young,Park, Cheol Woo,Son, Kyung Min,Cheon, Ji Seon 대한두개안면성형외과학회 2013 Archives of Craniofacial Surgery Vol.14 No.2

Background: If patients have a better understanding about their problem and treatment, compliance and satisfaction with treatment will increase. For this purpose, simple repeated explanations regarding a patients' problem and treatment are essential. Critical pathway (CP) has a very wide range in medicine with the exception of the plastic surgery field. The authors developed a CP for facial bone fractures and implemented it clinically. The aim of this study was to evaluate the effectiveness of the CP on the degree of recognition of the problem along with patient satisfaction with the treatment process. Methods: From May 2011 to October 2011, a total of 82 patients suffering from facial bone fractures were studied. The CP for facial bone fractures was developed by plastic surgeons, residents and nurses. Subsequently, the authors investigated the degree of recognition of the disease and patient satisfaction with the treatment through the use of a questionnaire. The authors compared the score of the questionnaires before and after implementation of the clinical pathway. Results: The degree of the recognition of the problem changed from 3.1 to 4.2 (p<0.001). Further, the degree of satisfaction with the treatment process changed from 3.6 to 4.3 (p<0.05). Overall, there was a two point increase in improvement. Conclusion: Implementation of the CP for facial bone fractures was effective in improving the degree of recognition and satisfaction. The authors expect that hereafter, the CP for facial bone fractures will be implemented actively in the plastic surgery field.

딥 러닝에 의한 전동기 고장진단에서의 LRP 알고리즘을 이용한 진단 데이터 분석

한지훈,최동진,박상욱,홍선기 대한전기학회 2020 대한전기학회 학술대회 논문집 Vol.2020 No.10

논문 1 : 백혈병 미세잔존질환 정량검출을 위한 실시간 역전사중합효소연쇄반응법의 유용성

조정애 ( Jeung Ai Cho ),김다운 ( Da Woon Kim ),정성두 ( Seong Du Jeong ),천지선 ( Ji Seon Cheon ),나경아 ( Gyeong Ah Na ),김진각 ( Jin Gak Kim ),김인환 ( In Hwan Kim ),김수현 ( Soo Hyun Kim ),신명근 ( Myung Geun Shin ) 대한임상병리사협회 2008 임상혈액검사학회 발표자료집 Vol.10 No.1

Background : Chromosomal rearrangements are major pathology inhematological malignancy. The detection of minimal residual disease(MRD) for these gene rearrangements helps in monitoring treatment outcomes and predicting prognosis. patients. Recently, quantification of these gene transcripts based on real-time quantitative polymerase chain reaction (RQ-PCR) has been used as MRD detection. The purpose of this study is to ensure the usefulness of the RQ-PCR technique for detecting MRD in hematological malignancy patients. Methods : The patients had been diagnosed to AML1-ETO positive AML, PML-RARa positive AML and BCR-ABL positive MPN (CML) at Chonnam National University Hwasun Hospital (CNUHH, Hwasun, Korea) from Jan. 2006 to Aug. 2008. The fusion transcript was quantified by RQ-PCR and analyzed in comparison to conventional cytogenetics, FISH and RT-PCR. Results : The fusion gene transcript was quantified by RQ-PCR in 57 samples from 14 patients with AML1-ETO positive AML, 79 samples from 27 patients with PML-RARa positive AML and 108 samples from 36 patients with CML. At diagnosis, the quantitative fusion transcripts for AM1-ETO, PML-RARa and BCR-ABL showed the range of 0.485552651 ~ 10.82233683 (mean 3.782217131, SD 2.998052348), 0.005300395 ~ 0.29267494 (mean 0.056901315, SD 0.080131381) and 0.1293929 ~ 12.94826849 (mean 1.701935665, SD 2.200913158). The increase of AML1-ETO fusion gene transcripts preceded morphologic relapse in two patients. Quantification of fusion gene transcripts by RQ-PCR could detected MRD in samples which were negative by in cytogenetics analysis or FISH. Conclusions : Our findings indicated that quantitative analysis of AML1-ETO, PML-RARa and BCR-ABL transcripts by RQ-PCR might be a useful tool for the monitoring of minimal residual disease in hematological malignancy.

백혈병 미세잔존질환 정량검출을 위한 실시간 역전사중합효소연쇄반응법의 유용성

조정애 ( Jeung Ai Cho ),김다운 ( Da Woon Kim ),정성두 ( Seong Du Jeong ),천지선 ( Ji Seon Cheon ),나경아 ( Gyeong Ah Na ),김혜란 ( Hye Ran Kim ),김진각 ( Jin Gak Kim ),김인환 ( In Hwan Kim ),김수현 ( Soo Hyun Kim ),신명근 ( Myung 대한임상검사과학회 2009 대한임상검사과학회지(KJCLS) Vol.41 No.1

Chromosomal rearrangements are major pathology in hematological malignancies. The detection of minimal residual disease (MRD) for these gene rearrangements helps in monitoring treatment outcomes and predicting prognosis of patients. Recently, quantification of these gene transcripts based on real-timequantitative polymerase chain reaction (RQ-PCR) has been used as MRD detection. The purpose of this study is to ensure the usefulness of the RQ-PCR technique for detecting MRD in hamatological malignancy patients. The patients had been diagnosed to AML1-ETO positive AML, PML-RARa positive AML and BCR-ABL positive MPN at Chonnam National University Hwasun Hospital from Jan. 2006 to Aug. 2008. The fusion transcript was quntified by RQ-PCR and analyzed in comparison to conventional cytogenetics, FISH and RT-PCR. The fusion gene transcript was quantified by RQ-PCR in 57 samples from 14 patients with AML1-ETO positive AML, 79 samples from 27 patients with PML-RARa positive AML and 108 samples from 36 patients with CML. At diagnosis, the quantitative fusion transcripts for AM1-ETO, PML-RARa and BCR-ABL showed the range of 0.485552651~10.82233683 (mean 3.782217131, SD 2.998052348), 0.005300395~0.29267494 (mean 0.056901315, SD 0.080131381) and 0.1293929~12.94826849 (mean 1.701935665, SD 2.200913158). The increase of AML1-ETO fusion gene transcripts preceded morphologic relapse in two patients. Quantification of fusion gene transcripts by RQ-PCR could detected MRD in samples which were negative by in cytogenetic analysis or FISH. Our findings indicated that quantitative analysis of AML1-ETO, PML-RARa and BCR-ABL transcripts by RQ-PCR might be a useful tool for the monitoring of minimal residual disease in hematological malignancies.