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Glutamate 억제제가 Pilocarpine에 의한 경련 및 기억장애에 미치는 영향
천임순,한형수,박정숙,정헌주,이만기,김중영 慶北大學校 醫科大學 1996 慶北醫大誌 Vol.37 No.3
목적 : Pilocarpine에 의한 경련 및 기억력 저하에 glutamate 수용체가 관련이 있는지 검토하였다. 대상 및 방법 : 생쥐에 pilocarpine을 투여하여 야기되는 경련 및 기억력저하가 glutamate 수용체 길항 약물인 MK-801 및 NBQX를 전처치하였을 때의 반응을 Morris Water Maze의 방법으로 관찰하였다. 결과 : MK-801과 NBQX를 전처치하고 pilocarpine을 투여하였는 바 pilocarpine에 의한 경련유발은 억제되지 않았으나, pilocarpine에 의한 reference memory와 working memory의 저하는 MK-801이나 NBQX를 처치로서 억제되었다. 결론 : Pilocarpine에 의한 경련작용에 비하여 기억력저허가 glutamte 수용체와 관련이 있는 것으로 보인다. The role of glutamate receptors in the genesis of pilocarpine-induced seizure and seizure-related memory deficit was studied using MK-801 and NBQX. After pretreatment with MK-801 or NBQX, pilocarpine was administered intraperitoneally. Both drugs had no effect on the behavioral seizure activity and onset of seizure activity. Memory was tested with reference and working memory version of Morris water maze at 20th day after pilocarpine treatment. Reference and working memory deficit was produced by pilocarpine. These deficit were prevented by MK-801 or NBQX, which were given in once a day for 4 day at 7th to 10th days after pilocarpine treatment. These results show that although MK-801 and NBQX do not have anticonvulsant property they can prevent pilocarpine-induced memory deficit.
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천임순(Ym Soon Cheon),김종일(Jeng Il Kim),반종석(J 대한통증학회 1993 The Korean Journal of Pain Vol.6 No.2
N/A Stellate ganglion block therapy is widely practiced in pain clinics for a wide variety of dis- eases(numbering over 150). The precise mechanisms are unknown, but it has been said that the systemic effect of the stellate ganglion block may improve the hypothalamic circulation and thus restoring the homeostasis of the body. We have administered stellate ganglion block for the treatment and cure of the following ex- amples of ailments idiopathic hypertension, allergic rhinitis, constipation, insomnia, irritable bowel syndrome. The causes of these diseases are unclear except that they are recognized as nervous disorders. However in clinical field, the effect of stellate ganglion block appears clear- ly. In this study 13 patients were treated only with stellate ganglion block; once daily for l5 days. The outcome of the treatments were as follows: 6 patients had excellent results, 5 pa- tients had good results and the remaining 3 with poor results. We conclude that stellate ganglion block appears to be a good choice as the treatment for a number of nervous disorders.
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천임순(Ym Soon Cheon),김종일(Jeng Il Kim),반종석(J 대한통증학회 1993 The Korean Journal of Pain Vol.6 No.1
N/A There are many patients who complain of shoulder pain with stiffness. Sadly these patients are often neglected by many physicians. An effective treatment is necessary in clinical prac- tice. In our pain clinic, the fifty patients who were diagnosed frozen shoulder were randomly selected and followed up from Oct. l992 to Mar. 1993. Important factors affecting outcome in- clude; time from onset of pain and stiffness until treatment, initial severity of the pain and stiffness. We found that appropriate treatment led overall to improved patient satisfaction. The results are as follows. For patients treated within 3 weeks of syndrome occurrence, the recovery rate was in excess of 80%. But, if the patients had suffered for more than 6 months prior to treatment, the recov- ery rate was below 70%. For problems present in excess of six years only slight improvement was observed. These patients were difficult to manage. If the condition of patients was class I, the recovery rate was 94.4%. But in the cases of class III, only 25% of patients were recovered. From our results, we believe that early treatment is the best choice in management of frozen shoulder patients.
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노선주(Joon Seock Goh),천임순(Ym Soon Cheon),민병 대한통증학회 1991 The Korean Journal of Pain Vol.4 No.2
N/A Stellate ganglion block was performed in 15 patients with intractable glaucoma by injection of 8 ml of ly lidocaine. The followings are the changes of intraocular pressure(mmHg); Pre -block 32.26±4.44 10 minutes after block 36.80±4.60 20 32.61 ± 4.41 30 28.87±4.30 60 24.73±4.37 120 26.87±3.I8 180 31.40±3.76 The pressure rose up to 10 minutes post block and significant pressure descent was noticed from 30 minutes post-block. Maximum descent was seen by 60 minutes post-block and pre- block pressure was restored by 180 minutes post-block. For the purpose of cheeking the treat- ment effect, similar blocks were performed in 15 patients, one time daily for 5-8 days 3 times every othor day.
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