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- 저자 : 채창식(Chang Sig Chae) (검색결과 3 건)
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확장형 심근증에서 도플러 심초음파를 이용한 좌심실 구혈력 및 내인성 심실 부하역동의 평가
채창식(Chang Sig Chae),이연재(Youn Jae Lee),박정현(Jeong Hyun Park),조기정(Gi Jeong Cho),김환태(Hwan Tae Kim),신형규(Hyung Gyu Shin),김동수(Dong Soo Kim),이경순(Kyung Soon Lee) 대한내과학회 1994 대한내과학회지 Vol.46 No.3
N/A Background: Since the concept of peak aortic blood velocity and peak acceleration by Rushmer et al, doppler echocardiography based on the hemodynamic theory has developed as a new noninvasive measure for the evaluation of left ventricular systolic function during the ejection time. Method: The left ventricular ejection force over the acceleration time and the intrinsic component of the left ventricular load at peak acceleration, measured by pulsed wave doppler echocardiography, were compared in 10 patients with idiopathic dilated cardiomyopathy with 9 normal controls. Results: 1) The fractional shortening, peak aortic blood velocity, mean acceleration and ejection force over the acceleration time were significantly lower in the dilated cardiomyopathy group than control group (control vs DCM =33.88±4.75% vs 17.21±5.99%, p<0 001, respectively). 2) By the regressin in the % fractional shortening,, measurement of ejection force over the acceleration time was more beneficial than measurement of peak aortic blood velocity and mean acceleration in assessing the left venticulat systolic function(r=63, 0.49 and 0.55 respectively). 3) The left ventricular intrinsic wall stress showed no significant statistical difference between 2 groups, but intrinsic σm/total σm ratio was significantly lower in the dialated cardiomyopathy group than control group (control vs DCM = 4.36±1.889: vs 1 88% vs 1.84±0.88% p<0.005). Conclusion: The measurement of the ejection force over the acceleration time and the left ventricular intrinsic wall stress/total ventricular load ratio were beneficial in evaluating the ejection hemodynamics during the left ventricular systole.
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채창식,이성근,이재윤,서정철,이상혁,설상영,정정명,최하진 인제대학교 1993 仁濟醫學 Vol.14 No.1
저자들은 장출혈과 급성 빈혈을 동반한 상부 공장의 평활근종 2례를 경험하고 문헌고찰과 함께 이를 보고하는 바이다. The small bowel tumors are often very difficult to confirm, and in many cases, these tumors are incidentally found during exploratory laparotomy. Sometimes, these tumors cause unexplained abdominal pain, intestinal obstruction, or intestinal hemorrhage, which leads to emergency surgical intervention with relatively high mortality. We report 2 cases of upper-jejunal leiomyoma with intestinal hemorrhage experienced in Inje University Pusan Paik Hospital in December, 1990 and January, 1991 with brief review of the cases.
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B형 만성 간 질환이 있는 소아와 성인에서 HBV core promoter, precore/core 유전자 부위의 돌연변이에 대한 고찰
정정명,박영홍,설상영,이상혁,장윤식,이연재,채창식 인제대학교 1998 仁濟醫學 Vol.19 No.2
B형 간염은 전세계적으로 수억의 인구가 감염되었을 뿐아니라 간경변증 및 간암의 중요한 원인으로 알려져 있다. 특히 우리나라는 B형 간염바이러스에 전 인구의 약 60%가 과거 HBV에 감염되었던 소견이 있다. 또한 만성 간질환 및 간암 환자의 약 60∼70%가 HBsAg 양성으로 우리나라에서는 HBV가 간질환의 가장 중요한 원인임을 알 수 있다. 그러나 현재까지 간염의 중증도에 어떤 요인이 작용하는지 밝혀져 있지 않다. 이런 점에서 저자들은 B형 간염 바이러스의 변이종과 간질환의 관계를 조사하였다. 변이는 성인에서 많은 경향을 나타내었는데 변이가 주로 발생하는 부위는 core promoter, precore/core 영역에 공히 존재하나 변이와 질환의 중증도와의 직접적인 관계는 관찰되지 않았다. Objectives: To clarify the frequency of mutations in core promoter, precore and core region of HBV(hepatitis B virus) and their possible effects on the clinical course of HBV associated chronic liver diseases. Methods and Materials: we performed PCR (polimerase chain reaction) and direct sequencing for the sera of 48 patients who had been HBsAg positive for more than 6 months (adult 31, children 17). And in this study, adult patients were divided into 3 groups according to the histopathological severity of liver disease i.e. Group 1 as minimal change and chronic persistent hepatitis. Group 2 as chronic active and lobular hepatitis, Group 3 as liver cirrhosis and hepatocellular carcinoma, respectively. Results: 1.The number of mutations at core promoter region did not show statistically significant difference between children and adults. In comparisons among Group 1 vs Group 2 and Group 1 vs Group 3, statistically significant differences were not seen either. About 53.3% of mutations occurred at nucleotide 1753, 1762 and 1764. 2.The number of mutations at precore region which were associated with amino acid changes did not show statistically significant differences between children and adults. And 63.3% of mutations were developed at codon 28(nucleotide 1896). In comparisons among Group 1 vs. Group 2 and Group 1 vs. Group 3, there were no differences in the numbers of mutations. The mutations at this region were more prevalent in Anti-HBe positive group rather than in HBeAg positive group (p= 0.013). 3.At the core region, total number of mutations which were associated with amino acid changes were more frequent in adults than in children. At CTL epitome (codon 18∼27), there were no significant differences of mutations between adults and children, In comparisons among Group 1 vs Group 2 and Group 1 vs Group 3, statistically significant differences were not seen either. CD4 epitope showed statistically significant differences between children and adults (p=0.025), but the histopathological severity was not related with the frequency of mutations. At the B cell epitome, there were significantly different rates of mutations between children and adults(p=0.038). Group 1 and 2 did not show differences, but Group 1 and 3 showed significance. Assuming that the hot spot as mutations over 10% of total cases, 5 spots were identified in children and 11 spots were identified in adults. The area of more frequent mutations in adults were codon 13∼27, 33∼49, 59∼63, 92∼97, 113∼117, which comprise 67.5% of all mutations. Conclusion: We could not find the definite relationships between the mutation in the core promoter, precore/core gene region of HBV and the histopathological severity of HBY associated liver diseases. Further investigations are needed with larger number of patients.
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