Ranicef의 임상효과

채성수,임창영 최신의학사 1990 最新醫學 Vol.33 No.5

결핵성 폐질환의 폐절제술후 폐기능 및 동맥혈가스 분석에 대한 임상적 고찰

채성수 대한흉부심장혈관외과학회 1993 Journal of Chest Surgery (J Chest Surg) Vol.26 No.11

We performed serial pulmonary function test and arterial blood gas analysis at preoperative period and postoperative 1st week in 337 patients who underwent pulmonary resection from May 1988 to April 1992 at Dept. of Thoracic and Cardiovascular Surgery, Seoul adventist hospital. Follow-up study for PFT and ABGA were possible in 30 % of the patients at postoperative 3rd or 4th month. In patient who underwent pneumonectomy, VC was decreased from 57.7% to 46.1%, FVC was decreased from 53.5 % to 41.2 % and MBC also decreased from 68.1% to 49.6 % at postoperative 1st week. But ABGA revealed that POa-, was increased from 87.2 mmHg to 92.7 mmHg, and PCO2 was decreased from 43.2 mmHg to 35.9 mmHg at postoperative 1st week. In patients who underwent lobectomy, VC was decreased from 78.1% to 68.30 %, FVC was decreased from 72.5% to 55.3% and MBC was decreased from 73.5% to 68% at postoperative 1st week.But, ABGA revealed that PO2 was increased from 95.2 mmHg to 97.9 mmHg and PCO2 was decreased from 42.3 mmHg to 39.0 mmHg at postoperative 1st week. The pulmonary function recovered at postoperative 3rd or 4th month and its ratio to preoperative value was 90% in lobectomy cases, but in pneumonectomy cases VC and MBC were recovered 20% and 15 % above the preoperative values. We concluded that resection of atelectasis, destructed lung, open negative and open positive cavity in the pulmonary tuberculosis were beni~t to improve ventilation-perfusion ratio,and pulmonary function was recovered nearly to preoperative level at postoperative 3rd or 4th month.

폐아세포종[보고 1예]

채성수,김광택,김형묵,Chae, Seong-Su,Kim, Kwang-Taek,Kim, Hyoung-Mook 대한흉부심장혈관외과학회 1981 Journal of Chest Surgery (J Chest Surg) Vol.14 No.2

A 39-year-old male was admitted to Dept. of Thoracic Cardiovasc. Surgery, Korea University Hospital with the chief complaints of progressively enlarged mass on right upper lung which revealed on routine chest P-A since 4 Years ago. Chest PA and tomography revealed well circumscribed huge mass of 7cm. in diameter without invasion on bronchus. so, right upper lobectomy was performed under impression of lung cancer. Postoperative pathologic examination revealed pulmonary blastoma. Pulmonary blastoma is accepted as a distinctive neoplasm recently. One case of typical pulmonary blastoma is reported, and the previous literature is reviewed. There are no specific clinical or radiologic feature of pulmonary blastoma. The presentation is can be that of any other pulmonary tumor although a peripheral situation is usual and a large size is often attained before detection. Pulmonary blastoma is a mixed tumor with malignant epithelial and connective tissue components with a distinctive resemblance to fetal lung. The treatment of choice is surgical excision but the overall prognosis is poor. There is no evidence of recurrence or metastasis on follow-up study during 6 months period after right upper lobectomy.

선천성 식도 폐쇄 및 기관식도루 4례 보고

채성수 대한흉부심장혈관외과학회 1983 Journal of Chest Surgery (J Chest Surg) Vol.16 No.1

Esophageal atresia and Tracheoesophageal fistula may occur as separate entities but usually occur in combination. First described by Durston in 1970, esophageal atresia was not successfully treated until 1939 when the first two survivors of staged correction were described by Ladd and Leven. In 1941, Haight and Towsley performed the first successful primary repair. Authors report four cases of esophageal atresia of which two cases were treated surgically in success with Haight`s method. The type of four cases were all the same as upper blind pouch and lower tracheoesphageal fistula. Two of them were associated with verterbral defect, imperforate anus and/or rib fusion. Two cases died within seven days due to parent`s refusal for operative therapy, others were treated surgically with Haight`s method. Operative patients tolerated all the operative procedure and recovered uneventfully, permitted feeding on 7th postoperative day. On follow up study, one patient revealed intermittent regurgitation and corrected with bougienation another with good health without complication.

대동맥궁 증후군의 수술치료 -2례 보고-

채성수 대한흉부심장혈관외과학회 1983 Journal of Chest Surgery (J Chest Surg) Vol.16 No.2

Aortic arch syndrome is an unusual disease entity characterized by the narrowing or obliteration of major branches of the arch of the aorta regardless of etiology. We have experienced 2 cases. One of them was 22 years old office girl with 3 months history of headache, intermittent syncope and weakness and claudication on left arm especially during her physical exercise. On physical examination, pulseless on left antecubital and radial artery and blood pressure on left arm was inable to check and coldness with weakness were noted on the same side. Aortic angiography reealed 34% narrowing of left subclavian artery as that of right. But both common carotid artery and both axillary arterial patency were relatively good. Through right supraclavicular and left axillary incision, bypass graft with Gore-tex prosthesis (I.D. 6mm, Length 25 cm) was implanted from right subclavian artery on 2cm distal to origin of right common carotid arery to left axillary artery distal to axillary fossa. End to side anastomosis with preservation of left subclavian artery was done. Postoperative state was stable with blood pressure of 110/70 mmHg on left arm and palpable antecubital and radial pulsation. Another one was 41 year old male patient with 8 months history of pain and numbness on right upper arm and shoulder. On admission, right arm blood pressure was 110/80 mmHg, left arm was 160/110 mmHg, but other physical findings had no abnormalities. Angiography revealed segmental narrowing of right axillary artery on the beginning with 2 cm in length. Operative treatment with right wupraclavicular and right axillary incision, bypass graft with great saphenous vein (Length; 15 cm) from right subclavian artery between scalenus anticus and medius to axillary artery at distal end of axillary fossa was done. The authors report two cases of Aortic arch syndrome treated with bypass graft using Autograft or Gore-tex with good result.

고립성 폐결절

채성수 대한흉부심장혈관외과학회 1982 Journal of Chest Surgery (J Chest Surg) Vol.15 No.2

The experience with operative treatment for peripheral situated solitary circumscribed lesions of the lung at the Department of Thorac. & Cardiovasc. Surg., Korea University Hospital during 8 years from March 1974, through April, 1982 was reviewed. Our criteria for Solitary pulmonary nodule were 1. Round or Ovoid shape 2. Surrounded by normal lung Parenchyme 3. Well circumscribed peripheral location 4. No other visible pulmonary diseases on chest X-ray except minimal atelectasis or pneumonitis 5. Largest diameter less than 8 cm Of the 55 patients reviewed, there were 69% of malignancy and 31% of benign pulmonary diseases. In malignancy 38 patients, there were 18 patients with squamous cell carcinoma, 8 patients with undifferentiated large cell carcinoma, 2 patients with undifferentiated small cell carcinoma, 10 patients with adenocarcinoma and patient with metastatic carcinoma. In benign pulmonary nodule 17 patients, here were 5 patients with tuberculoma, 5 patients with aspergilloma, 2 patients with A-V fistula, 1 patient with pulmonary blastoma, 1 patient with paragonimiasis, and 1 patient with lung abscess. Overall male to female occurrence ratio was 39:16, and most prevalent age incidence was 7th decades. Most frequent size distribution was 4-6 cm in diameter. All of benign diseases were cured by resection and 66% of malignancy performed operation and has 75% resectability.

Fallot 4징증의 근치수술에 대한 임상적 고찰

채성수 대한흉부심장혈관외과학회 1983 Journal of Chest Surgery (J Chest Surg) Vol.16 No.3

The experience with operative treatment for total correction of Tetralogy of Fallot at the department of Thoracic and Cardiovascular Surgery, Korea University Hospital from January, 1977, through April, 1983 was reviewed. Of the 29 patients reviewed, male to female occurrence ratio was 22:7 Type of V.S.D. was type II in 26 cases[90%] and total conus defect in 3 cases[10%]. Average size of V.S.D. was 19 mm. Type of Right ventricular outflow tract stenosis was highest frequency with pulmonary valvular and infundibular stenosis combined type in 21 cases[72%], and there were 8 deaths In this group. Type of R.V.O.T. reconstruction contains 2 cases of infundibulectomy only, 1 case of infundibulectomy with valvular commissurotomy, 2 cases of pericardial patch, 23 Cases of pericardial patch with Teflon or Dacron felt reinforced and 1 case of pulmonary valved conduit reconstruction. Operative mortality was higher in outflow patch through pulmonary valve ring. Overall mortality was 31%. Major causes of death and postoperative complications were low output syndrome, complete A-V block acute renal failure, ventricular fibrillation, bleeding brain abscess, and sudden cardiac arrest.

심근보호액 조성이 관상동맥에 미치는 영향에 대한 연구

蔡誠洙,金炯默 고려대학교 의과대학 1985 고려대 의대 잡지 Vol.22 No.1

The effects of the composition of cardioplegic solutions on coronary arterial strips and the additional effects of calcium antagonist (Verapamil) on cardioplegic solutions were studied with isolated canine coronary arterial strips. The cononary arterial strips were dissected spirally from 3 main coronary arteries in 1-1.5㎜ in diameter, 2-4㎜ width, 20-35㎜ length of Mongrel dogs. Isometric active tension of coronary arterial strips recorded with Biocom isometric transducer and physiograph at a resting tension of 500-750 mg after 1 to 11/2 hr period of equilibration superfused in tyrode solution. This study composed with group of effect of basic ionic component of cardioplegic solutions and group of experimental effects of various cardioplegic solutions with additives on coronary arterial strips. The potassium brought about a dose dependent contraction of the coronary arterial strips over 8 mEq/L to 30 mEq/L above 18℃ in temperature. The calcium had additive contraction of the coronary strips previously contracted by G-K(Glucose-potassium) solution over 0.6 mEq/L and as much as twice at 2.0 mEq/L in 37℃. Addition of the magnesium to calcium chelated G-K solution with small dose and related beyond primary isometric tension level over 30 mEq/L infusion. Simple G-K solution, St. thomas' hospital solution, Bretschneider solution and Blood cardioplegic solution have contracted markedly the coronary strips near similary in spite of the difference of their composition. Addition of Verapamil 2.0 mg/L to the cardioplegic solutions abruptly diminished or absent the contracting effect of various cardioplegic solutions. In most cases, the hypothermia slightly reduced vasoconstriction and enhanced vasodilatation. The results suggest that the various potassium contained cardioplegic solutions with or without calcium brought about a contraction of the coronary arterial strips in similar pattern but the contraction effects were diminished with addition of magnesium or calcium antagonist, as well as hypothermia.

반능동형 머플러

채성수 한국발명진흥회 2003 發明特許 Vol.28 No.3

자폐장애 아동의 염색체 분석

채성수,정철호,하재창 대한신경정신의학회 1992 신경정신의학 Vol.31 No.4

The authors studied chromosomal abnormalities in 30 autistic children meeting the diagnostic criteria of DSM-III-R in order to evaluate association between autistic disorder and fragile X syndrome. All samples were analyzed 100 metaphase cells on short-term lmyphocyte cultures in Medium 199 that contained FUdR. Numbers of chromosome were 46XX or 46XY in all samples. One autistic boy was found having one fragile X chromosome among 100 cells, but this finding is negative since positivity of fragile X syndrome was defined as 3%(3 out of 100) of cells being positive for fragile Xq27-28. Other chromosomal abnormalities, such as gap and breakage, were found in 3 boys. These results does not support the hypothesis that fragile X syndrome is an etiological factor in autistic disorder. Therefore, a further research of fragile X syndrome in larger populations of autistic disorder, mental retardation and normal control groups is needed to confirm whether fragile X syndrome plays any part in the development of autistic disorder