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조직학적으로 확진한 결핵성 복막염 환자의 복수 Adenosine deaminase ( ADA ) 활성도에 관한 연구
배선우(Seon Woo Bae),진춘조(Choon Jo Jin),심영학(Young Hak Shim),신계철(Kye Chul Shin),권상옥(Sang Ok Kwon),김남동(Nam Dong Kim),차신웅(Shin Woong Cha),이광훈(Kwang Hoon Lee),장우익(Woo Ick Jang) 대한내과학회 1989 대한내과학회지 Vol.36 No.1
N/A Recent investigations have suggested that the measurement of ADA activities in various body fluids is useful in the diagnosis of tuberculous effusion. In this study, ascitic fluid ADA activities were measured in 18 cases of tuberculous peritonitis, 18 cases of malignant ascites and 33 cases of liver cirrhosis with ascites. The results obtained were as fallows: 1) The mean ADA activity in tuberculous peritonitis was 184.96±27.55U/L, in malignant ascites 22.35±3.10U/L and in liver cirrhosis 7.37±0.61U/L. 2) The ADA activity in tuberculous effusion was significantly higher than in the rest of the groups(p<0.001). 3) The malignant effusion show no significant difference with transudative effusion(p>0.05). 4) As a screening test for tuberculous peritonitis, the ADA activities above 50-70U/L had a sensitivity and specificity of 100%. In conclusion, the measurement of ascitic fluid ADA activity may be a simple and reliable screening test for the diagnosis of tuberculous peritonitis.
차신웅,용석중,박진현,신계철 대한내과학회 1990 대한내과학회지 Vol.38 No.1
Adenosine deaminase(ADA) is an enzyme whcih catalyzes the irreversible hydrolytic deamination of adenosine to produce inosine and ammonia. Recent investigations have demonstrated that the deamination of ADA activities in pleural fluid, cerebrospinal fluid and ascites is useful in the differential diagnosis of tumberculosis in those fluids. In this study, serum ADA activities were measured in 13 cases of miliary tuberculosis, 40 pulmonary turberculosis, 17 cases of pneumonia, 13 cases of pneumoconiosis, 8 cases of metastatic lung cancer and 40 cases of normal controls. The results obtained were as follows: 1) The mean serum ADA activity in miliary tuberculosis 93.85±33.93 U/L, pulmpnary tuberculosis was 38. 85±11.99 U/L, pneumonia 25.02±7.57 U/L, pneumonia 26.71±8.91 U/L, metastatic lung cancer was 27.48±9.38 U/L and normal control 19.22±4.03 U/L. 3) The serum ADA activity above 70 U/L had a sensitiveity of 77% and a specificity of 93% when used as a screening test for miliary tuberculosis compared to pulmonary tuberculosis. 4) There was no statistical correlation between the serum ADA activity and the SGOT, SGPT, and alkaline phosphatase in miliary tuberculosis. 5) After antituberculous therapy, serum ADA activity tended to slightly decreased for 4 weeks but marked decrease after 8 weeks. It is suggested that measurement of ADA activity in serum is an available test which is relatively easily performed for diagnosis of miliary tuberculosis.