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한국인 HBsAg 양성간질환환자에 있어서 HBeAg 및 anti - HBe 의 검출성적
박형근(Hyoung Gun Park),김익모(Ik Mo Kim),이재준(Jae Hun Lee),김경진(Kyung Jin Kim),지혜기(Hye Kee Jee) 대한소화기학회 1982 대한소화기학회지 Vol.14 No.2
N/A Authers carried out studies to determine the frequency of HBeAg and anti-HBe in the serum of l4 patients with HBsAg-positive liver diseases, wbo were diagnosed by clinically, biochemically, serologically and morphologically from March, 1980 to Sept., 1981 in Department of Internal Medicine, Gospel Hospital, Kosin Mfedical College. HBsAg, HBeAg and anti-HBe were measured by method of solid phase radiommunoassay with the Abbott- Ausria system. We also investigated the correlation between HBeAg and findings of chemical liver function test. The results obtained were summarized as follows; 1) The positivity of HBeAg was 84.6% in chronic active hepatitis, 66. 7% in acute type B hepatitis, 62.5% in chronic persistent hepatitis, 61.4% in liver cirrhosis, 46.27% in primary hepatoma, and 28. 0% in asymptomatic HsAg carriers. The positivity of HBeAg in acute and chronic hepatitis and liver cirrhosis was significantly higher than that in prirmary hepatoma and aSx HBsAg carriers. 2) The positivity of anti-HBe was 50.0% in aSx HBsAg carriers, 46. 2% in primary hepatoma, 25.0% in chronic persistent hepatitis and liver cirrhosis, and 15.2%. In acute type B hepatitis, respectively. The anti-HBe was not detected in chronic active hepatitis. The positivity of anti-HBe in aSx HBsAg carriers and primary hepatoma were significantly higher than that of the others. 3) In aSx HBsAg carriers and patients with acute type B hepatitis, liver cirrhosis and primary hepatoma, mean levels of serurn GPT, GGTP, bilirubim, or alpha-fetoprotein were not significantly different between patients with and without HBeAg. 4) In chronic active and persistent hepatitis, mean levels of serum GPT of the patient with HBeAg were significantly higher than that of the patients without HBeAg, but serum bilirubin levels were not distinctly different between them. On the basis of above findings, it was suggested that HBeAg is chiefly detected in patients with HBsAg(+) active liver disease such as acute and chronic hepatitis, while anti-HBe chiefly detected in patients with inactive liver diseases such as asymptomatic HBsAg carriers and primary hepatoma.
양지혜 ( Ji Hye Yang ),이덕우 ( Deok Woo Lee ),원종현 ( Chong Hyun Won ),장성은 ( Sung Eun Chang ),이미우 ( Mi Woo Lee ),강윤구 ( Yoon Koo Kang ),최지호 ( Jee Ho Choi ),문기찬 ( Kee Chan Moon ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.3
Erythrodermic mycosis fungoides (MF) denotes a condition in which erythroderma occurs in patients with otherwise typical clinical features of MF. Gemcitabine is a novel treatment regiment for MF. A 16-year-old boy presented in the hospital with skin lesions that showed generalized erythema with scaling, several plaques, and nodules with ulceration on the extremities and trunk. He was diagnosed with erythrodermic MF. His lesions did not improve with methotrexate (7.5 mg/week) and PUVA for 6 months, so his treatment regimen was changed to systemic gemcitabine therapy (1,000 mg/m2 per week). After 6 cycles of gemcitabine, his skin lesions disappeared. We report a case of erythrodermic MF treated by gemcitabine. (Korean J Dermatol 2010;48(3):232~236)
양지혜 ( Ji Hye Yang ),원종현 ( Chong Hyun Won ),장성은 ( Sung Eun Chang ),이미우 ( Mi Woo Lee ),최지호 ( Jee Ho Choi ),문기찬 ( Kee Chan Moon ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.5
Background: Lupus erythematosus tumidus (LET) is a rare subset of chronic cutaneous lupus erythematosus, and LET is clinically characterized by erythematous, succulent, urticarial plaques on the sun-exposed areas and LET is histopathologically characterized by the presence of perivascular and periadnexal lymphocytic infiltrates with interstitial mucin deposition. Objective: We investigated the clinical and histopathological features of LET in Korean patients. Methods: A retrospective study was conducted on 18 patients who were diagnosed with LET between 1993 and 2010. The clinical characteristics, histopathological and laboratory findings, association with other subsets of lupus and the course of disease were analyzed. Results: LET occurred predominantly in females, with the gender ratio being 1:8. The mean age at diagnosis was 31.3 years. Two of 18 patients (11.1%) were previously diagnosed with systemic lupus erythematosus (SLE) or they had discoid lupus erythematosus (DLE) simultaneously. The most common clinical features were erythematous patches, nodules or plaques and the most common site was the face. Eight of eighteen patients (44.4%) had photosensitivity and this value was lower than that of the previous reports. The antinuclear antibody (ANA) was negative or weakly positive in 13/15 (86.7%) cases. The main histopathological characteristics were perivascular and/or periadnexal lymphocytic infiltrates, and interstitial mucin deposition. Epidermal changes were absent or there were minimal changes. The treatments included antimalarial drugs, dapsone and topical and systemic corticosteroid. The patients showed a good response to the treatments without scarring. Conclusion: A clinicopathological review of 18 LET cases revealed results that were similar to those of the previous reports, although there were some differences in the gender ratio and frequency of photosensitivity. Further studies are needed to elucidate the cause of such differences. (Korean J Dermatol 2010;48(5):402~408)
양지혜 ( Ji Hye Yang ),김정은 ( Jeong Eun Kim ),원종현 ( Chong Hyun Won ),장성은 ( Sung Eun Chang ),이미우 ( Mi Woo Lee ),최지호 ( Jee Ho Choi ),문기찬 ( Kee Chan Moon ) 대한피부과학회 2011 大韓皮膚科學會誌 Vol.49 No.1
Acantholytic acanthoma is a rare benign neoplasm of epidermal keratinocytes and this commonly displays as a solitary, asymptomatic keratotic papule on the trunk. The histologic features are hyperkeratosis, acanthosis, papillomatosis and prominent acantholysis. Dyskeratotic cells are occasionally present, but prominent dyskeratosis is not a characteristic feature of acantholytic acanthoma. Herein, we report on a case of acantholytic acanthoma with several dyskeratoses, and this occurred in a 54-year-old woman who presented with a keratotic plaque that repeatedly pealed on the umbilicus. (Korean J Dermatol 2011;49(1):79~81)
이덕우 ( Deok Woo Lee ),양지혜 ( Ji Hye Yang ),원종현 ( Chong Hyun Won ),장성은 ( Sung Eun Chang ),이미우 ( Mi Woo Lee ),최지호 ( Jee Ho Choi ),문기찬 ( Kee Chan Moon ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.5
Cutaneous and systemic plasmacytosis is a rare disorder that`s characterized by a cutaneous plasma cell infiltrate accompanied by polyclonal hypergammaglobulinemia. Clinically, it appears as multiple red-brown plaques that mainly occur on the trunk, and this is sometimes associated with variable extracutaneous involvement. All the cases of cutaneous and systemic plasmacytosis reported in Korea have shown the typical skin manifestations on the trunk of the patients. Herein, we report on a case of cutaneous and systemic plasmacytosis and the patient presented with multiple erythematous to brownish patches on the face, neck and both axillary areas. (Korean J Dermatol 2009;47(5):558~561)
이우진 ( Woo Jin Lee ),양지혜 ( Ji Hye Yang ),이미우 ( Mi Woo Lee ),최지호 ( Jee Ho Choi ),문기찬 ( Kee Chan Moon ),고재경 ( Jai Kyoung Koh ) 대한피부과학회 2008 大韓皮膚科學會誌 Vol.46 No.11
Childhood granulomatous periorificial dermatitis is a granulomatous disease that`s characterized by monomorphous, small papular eruptions around the mouth, nose and eyes. The condition is benign and self-limiting and it is not associated with systemic involvement. We recently encountered a 7-year-old Korean boy with multiple, discrete, monomorphic, papular eruptions of 4-week duration on the perioral, periocular and perinasal areas. Histopathological examination revealed an upper dermal and perifollicular granulomatous infiltrate. He was treated with oral erythromycin and the condition resolved without leaving any scar. (Korean J Dermatol 2008; 46(11): 1570∼1572)
이덕우 ( Deok Woo Lee ),양지혜 ( Ji Hye Yang ),원종현 ( Chong Hyun Won ),장성은 ( Sung Eun Chang ),이미우 ( Mi Woo Lee ),최지호 ( Jee Ho Choi ),문기찬 ( Kee Chan Moon ) 대한피부과학회 2009 大韓皮膚科學會誌 Vol.47 No.6
Rudimentary menigocele is a developmental anomaly in which menigothelial elements are present in the skin and subcutaneous tissue. A 9-year-old boy presented with a well-circumscribed, central atrophic and alopecic patch on the midline of the occipital area, and this lesion had been present at birth. Histological examination showed dense collagen bundles with pseudovascular spaces lined by oval, spindle shaped cells in the dermis and the subcutaneous layer. Collagen bodies and psammoma body were also detected. On the immunohistochemistry, these oval, spindle shaped cells were positive for vimentin, but negative for CD31, EMA and S100 protein. (Korean J Dermatol 2009;47(6):743∼745)