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치근단질환에서 형질전환성장인자-β와 기질금속함유단백분해효소 발현에 관한 연구
지정호,진태호 원광대학교 치의학연구소 1999 圓光齒醫學 Vol.9 No.1
The periapical response to injury is a complex interaction of inflammatory, immune, neural, vascular and synthetic activity. TGF-β is a potent modulator of proliferation and differentiation in various tissue, seems to lead to an increase in extracellular matrix. MMP are a family of proteolytic enzyme that mediate the degradation of extracellular matric macromolecules, but little is known about theirs possible role in periapical tissue. The purpose of this study is to investigate the differential expression of TGF-β and MMP-1 in tooth follicle, periapical abscess, granuloma and cyst. The expression of TGF-β and MMP-1 in Periapical tissue was evaluated by immunohistochemical staining and Western blot analysis. Correlationship among the periapical lesions were stastically analyzed. The degree of MMP-1 expression in periapical abscess was higher than in any other periapical lesion, and stastically significant. TGF-β expression is the prominent in granuloma than other periapical lesion, which was stastically significant. The increased expression of MMP and TGF-β was not co-related with inflammatory cell infiltration degree of the periapical cyst. The expression degree of MMP and TGF-β was not co-related with periapical abscess and cyst, but expression of MMP and TGF-β showed strong positive co-relationship with periapical granuloma, which was stastically significant. TGF-β expression by Western blot analysis was prominent in granuloma and cyst, and similar to the results by imunohistochemistry. MMP-1 expression is less than TGF-β , but there is not extreme difference between periapical lesion. These results suggest that TGF-β and MMP may be involved in tissue remodeling and has an important role in progress or mediation of periapical lesions.
감염근관에서 분리한 세균의 동정 및 항생제 감수성 검사
지정호,임미경 원광대학교 치의학연구소 1994 圓光齒醫學 Vol.4 No.2
Bacteria have been regarded as major etiologic factors in root canal infections. Infected root canal flora from thirteen patients who had visited to conservative department of Wonkwang dental hospital were cultured on blood agar plates. Cultured microorganisms were isolated and identified with Gram stain and biochemical tests using Vitek Systems (BioMeriux, MO, USA). Antibiotic susceptibility was performed with disk diffusion and broth microdilution using Vitek Systems. Gram positive cocci (65%) were predominant, which were composed of 6 Streptococcus viridans group. 5 Staph. spp., and 4 Enterococcus faecium, in the isolated 23 strains. Gram negative rods (26%) were the next common bacteria, which were composed of 5 nonfermentative Gram negative rods, and 1 Enterobacter cloacae. Most strains of S, viridans group and E. faecium were susceptible to antibiotics including penicillin. But strains of Staphylococcus spp. and non-fermentative Gram negative rods showed marked resistance to antibiotics except tetracyclin and cefotaxime. Most results between disk diffusion and microdilution were all agreed, but the results of non -fermentative Gram negative rods were susceptible to cefotaxime in disk diffusion method but resistant in microdilution.
가압식 오실로메트릭 방법을 사용한 혈압측정 시스템의 설계
노동곤,이윤선,지정호,박성빈,이계형,김해관 대한의용생체공학회 2003 의공학회지 Vol.24 No.4
혈압은 사람의 건강상태를 알 수 있는 가장 기본적인 의학적 파라메터 중 하나이며, 오실로메트릭 방법을 사용한 혈압측정 시스템은 팔 동맥에서 커프를 통해 나타나는 압력을 측정함으로써 혈압수치를 비침습적으로 모니터링 하는 장치이다. 된 논문에서는 커프에 공기를 주입하면서 혈압을 측정하는 가압식 손목형 혈압측정 시스템을 설계하였다 설계한 혈압측정 시스템은 전원부와 압력을 가하는 공기주머니를 포함하는 커프, 신호검출부, 신호처리부, 무선 송수신부 그리고 디스플레이부로 구성된다. 설계한 자동 혈압측정 시스템은 기존에 일반적으로 사용되고 있는 자동혈압측정 시스템과의 수축기, 이완기 혈압 및 심박동수의 비교분석을 통해 신뢰성을 평가하였다. 수축기 혈압과 이완기 혈압을 결정하기 위해 MAA (Maximum Amplitude Algorithm)를 사용하였고, 적용한 특성비율은 0.436. 0.671이 었다. Blood Pressure is one of the most fundamental Parameters which reflects physical conditions medically and the blood pressure measurement system using oscillometric method is a Non-Invasive Blood Pressure measurement device by measuring arterial Pressure through a cuff. In this paper. we designed a inflatable wrist blood pressure system which measures blood Pressure during the stepping inflation in the wrist cuff. The hardware system consists of a main power unit, a bladder in cuff unit, signal detection units, signal Processing units. a wireless data transmission unit, and a data display unit. We evaluated the reliability of this system by comparing and analyzing systolic. diastolic blood Pressure, and heart rate with other commercial blood Pressure measurement devices. Characteristic ratio values used to determine systolic and diastolic blood Pressure using MAA(Maximum Amplitude Algorithm) were 0.436 and 0.671 respectively.