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골수암유래 암세포주 KHOS/NP와 MG-63의 성장에 미치는 마늘의 암세포 독성효과
이정석,임성남,오명숙,지은정 全北大學校 齒醫學硏究所 1993 전북치대논문집 Vol.11 No.1
Most anticancer drugs so far used have brought many side effects to the host, which is inevitable since they can not specifically distinguish between cancer cells and rapidly dividing normal cells. Therefore, it is very important to develope a chemopreventive agent proven for a long period of time not to toxic to normal cells. Since garlic has been attracted interests from many areas of cancer researchers as a potent anticancer agent, attempts were made to see the direct cytotoxic effect of garlic to human osteosarcoma cell lines. The present study was designed to investigate the effect of garlic on the two cell lines of rapidly growing osteosarcoma with comparable doubling time of 20 hours, namely KHOS/NP and MG-63. Four different garlic preparations commnly used in the Koreans, that is, raw and heated garlic dissolved in distilled water, raw and heated garlic dissolved in saline were compared in thier cytotoxic effect to the KHOS/NP and MG-63. The results obtained were as follows. 1. Raw garlic dissoved in distilled water showed the best cytotoxic effect among four different preparations of garlic used in this study. 2. The cytotoxic effect of garlic to the osteosarcoma was different, to the cell lines showing mostly more effective to KHOS/NP than to MG-63. 3. To KHOS/NP, the cytotoxic effect of garlic was markedly increased with concentrations but not with incubated time. 4. To MG-63, the cytotoxic effect of garlic w3s increased both with concentrations and incubated time. 5. The difference of inhibitory action of garlic between KHOS/NP and MG-63 was marked when heated garlic in saline was treated at high concentration(0.1875g% ) for 48 hours.