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허혈-재관류 손상에서 히스타민 차단제와 류코트리엔 수용체 길항제의 효과 비교
조혜인,장학,김석화,Cho, Hye-In,Chang, Hak,Kim, Suk-Wha 대한미세수술학회 2012 Archives of reconstructive microsurgery Vol.21 No.1
Purpose: The purpose of this study was to investigate the role of mast cells and their product, histamine and leukotriene in ischemia-reperfusion injury. Methods: Forty Sprague-Dawley rats were divided into four groups. (Group I: Control group without ischemia, Group II: Normal saline with ischemia, Group III: Cimetidine with ischemia, Group IV: Zafirlukast with ischemia) Skin flap was elevated and ischemic insult was given by clamping the artery for 12 hours. Before reperfusion, the rats were treated with saline, cimetidine and zafirlukast. Flap survival was evaluated at 7 days. Neutrophil counts, mast cell counts were evaluated 24 hours after reperfusion. Results: Flap survival rate in the control group was 92.33%, whereas normal saline group had 37.34% survivals. Cimetidine and zafirlukast treated group showed significantly higher survival rates than normal saline group. The neutrophil and mast cell counts in cimetidine and zafirlukast treated group were significantly decreased than normal saline group. Cimetidine treated group showed higher survival rate and lower cell counts than zafirlukast treated group. Conclusion: The administration of cimetidine and zafirlukast can decrease neutrophils and mast cells caused by ischemia-reperfusion and increase flap survivals. It is suggests that antihistamine and leukotriene receptor antagonist have protective effect against ischemia-reperfusion injury to skin flap in rat.
전외측 대퇴부 감각 유리피판을 이용한 전족부 탈장갑 손상 재건
조혜인,은석찬,백롱민,Cho, Hye-In,Eun, Seok-Chan,Baek, Rong-Min 대한미세수술학회 2010 Archives of reconstructive microsurgery Vol.19 No.2
The forefoot reconstruction is a challenging field for plastic surgeons. Weight bearing tolerability and stability are important factor of choosing reconstruction methods, but cosmetic aspect has to be considered. 51 year old man visited our clinic with extensive degloving injury on right forefoot by roller. The soft tissue defect started from metatarsal area to the toe tip including nails. We harvested the anterolateral thigh flap and transferred it to the forefoot defect area with nerve coaptation. The flap was successful without skin necrosis or other complications. Secondary flap debulking surgery was performed after ten months from initial operation. Patient was satisfied with functional and cosmetic outcomes. The patient was able to wear shoes and walk with adequate sensory recovery. As there is few report about reconstruction of forefoot soft tissue defects, we report a unique case of the anterolateral thigh innervated free flap reconstruction in degloving injury.
조혜인 ( Hein Cho ) 한국사회사학회 2006 사회와 역사 Vol.0 No.71
Ideal type is an extremely significant methodological tool for the study of society and history. The concept of ideal type was derived from Max Weber`s pluralistic world view. The finite human mind can only draw a partial picture of any given object. The values, or the problematic, of the researcher will come into play when he focuses on a specific aspect of the object and draws such a partial picture, or an ideal type. Weber suggested that because the store of values is inexhaustible, ever new and different ideal types might be possible. This paper sought to clarify whether or not the infinite plurality of ideal types might be equally important in terms of their ontological positions in the object or in terms of the practical desirability of their values. We concluded that both ontology and praxiology postulate an emergent though ultimately unfixable order of priority. A certain ideal type can be more important than another because it focuses on a more important aspect of the object itself or because it is related to more important ethical goodness. Thus, ideal types are differentially pluralistic. However, which aspect or goodness is more important cannot be determined decidedly. And there always remains room for competition for the ultimately unfixable order of priority.
바이오 이미징을 위한 업컨버전 나노입자(upconversion nanoparticles)의 합성 및 특성화
조혜인(Hye In Cho),이재승(Jae-Seung Lee) 한국세라믹학회 2018 세라미스트 Vol.21 No.3
The increasing importance of biomedical imaging technology has led to the development of a variety of luminescent materials, including molecular fluorophores, fluorescent proteins, and quantum dots. Owing to their inherent disadvantages, such as insufficient chemical stability and limited biocompatability, their utilization has been limited with imaging only under highly optimized and controlled conditions. Recently, a new class of luminescent nanoparticles, upconversion nanoparticles (UCNPs), have been emerging as a practically useful nanoprobe for various bioimaging applications. The detailed synthesis, functionalization, properties and in-vitro / in-vivo applications of the UCNPs are introduced and discussed in this Review.