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조성필 ( Sung Pill Cho ) 한국공업화학회 2022 공업화학전망 Vol.25 No.2
LNG를 연소하는 복합화력발전소는 석탄화력발전소에 비해 대기오염물질 배출량이 적어 친환경적이라고 할 수 있으나, 질소산화물이 여전히 배출되고 있고, 최근에는 가스터빈 기동시에 발생하는 황연 유발물질, 일산화탄소, 총탄화수소가 민원의 대상이 되고 있다. 또한 온실가스인 CO<sub>2</sub> 역시 연소과정에서 불가피하게 발생하는 물질이다. 친환경적인 에너지로 거듭나기 위해 산업계에서 이들 대기오염물질을 적정하게 처리하기 위한 노력이 진행되고 있다. 본 고에서는 복합화력발전소에 적용된 상용화 기술에 대해 현황을 설명하고 향후 적용될 기술에 대한 연구개발 사항에 대해 소개하고자 한다.
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화상을 입힌 흰쥐에서 장관내 진균의 전위와 면역능의 변화
임풍,한기택,양성열,조성필 大韓成形外科學會 1993 Archives of Plastic Surgery Vol.20 No.5
Sepsis still remains the major cause of morbidity and mortality after initial survival from extensive burn. It has been confirmed that increased translocation of enteric microrganism to the mesenteric lymph nodes and blood flow in association with burn injuries had taken place in otherwise healthy animals. Candida albicans is one of the microflora responsible for sepsis, and its incidence in burned patients has steadily increased. The passage of viable C.albicans through the gastrointestinal mucosa into the host blood stream is believed to be an important mechanism leading to systemic candidiasis. Several lines of evidence suggest that the immunosuppression of cell mediated immuity(CMI) was due to decreased Th/Ts ratio in burned patients and CMI was specifically suppressed by C. albicans. The aim of this study is to investigate the relationship and serial changes between the translocation of C.albicans and burn injuries and to clarify the fact that whether the translocation of C.albicans suppress the immunocompetence by observing the changes of lymphocyte subpopulation in burned rats in which the translocation of C.albicans were found. Normal Wistar rats were challenged intragastrically with C.albicans prior to a 40% scald burn in the candida-burn experimental group. Tissues harvested from the mesenteric lymph node, liver, spleen, thymus, jejunum, cecum and colon on the lst, 3rd, 5th&7th postexperimental days and cultured on Sabouraud dextrose agar and then sitained with periodic-acid Schiff(PAS) to observe the transolcation of C.albicans. Also the lymphocytes were isolated from peripheral blood of the rats at the immediate before the experimentation, lst, 3rd, 5th and 7th postexperimental days and then the subpopulations were measured by flow-cytometry; All findings were compared with those of each control(gavage with phosphate buffered saline(PBS)+shame burn), candida experimental(gavage with C. albicans+shame burn) and burn experimental(gavage with PBS+40% scald burn) groups. The results were as follows; 1. In the candida experimental group, C.albicans were found to only the mesenteric lymphnode in the early experimental period. In the candida-burn experimental group, the translocation of C.albicans increased more significantly than that of the candida experimental group and the translocation was maintained up to the 7th post experimental day. 2. On microscopic examination, intestinal mucosal atrophy occured after burn injuries. C. albicans seem to have passed through the intestinal mucosal barrier and then they were phagocytized by macrophages in the lamina propria. Also most of C. albicans which had infiltrated into the other organs were phagocytized by macrophages, but some were free. In the candida-burn experimental group, C. albicans were found in the blood vessel of the liver and thymus on the lst postexperimental day and they had infiltrated into the organs at a greater rate than that of the candida experimental group. 3. In the candida-burn experimental group, the Th/Ts ratio was significantly decreased on the 3rd, 5th and 7th postexperimental days compared to that of the pre-experimental day. On the lst and 7th days, such diminution was significant as compared with the control group and on the 3rd, 5th days, the Th/Ts ratio had decreased more significantly than that of the control and candida experimental groups. But at all intervals, no statistical significance was found as compared with the burn experimental group. With these results it is inferred that burn stress promotes the translocation of C.albicans from the gastrointestinal tract to other organs and the translocation induced by burn injuries is maintained persistantly up to the 7th postexperimental day. And the translocation of C.albicans in burned rats seems not to enhance the depression of CMI through burn injury. But more study will be necessary to understant the immunologic alteration between the translocation of C.albicans and burn injuries.
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화상을 입힌 흰쥐에서 장관내 Candida albicans 전위에 대한 Ketoconazole의 예방적 효과
정성한,조성필,한기택,오영환,임 풍 大韓成形外科學會 1994 Archives of Plastic Surgery Vol.21 No.4
Despite of many advances in both topical and systemic control of infections, candida sepsis continues to be a serious complication following major thermal injury. The translocation of enteric C. albicans may be occured to be associate with major burn injuries. Ketoconazole is an oral antifungal agent that has been effective in the treatment of many fungal infections. However, the results of prophylactic clinical and laboratory trials using ketoconazole have been inconsistent. The aim of this study is to determine the prophylactic effect of oral ketoconazole on the translocation of enteric C. albicans in major burn injuries. Normal rate recieved ketoconazole (10㎎/㎏/day) 24 hours prior to a 40% scald burn and were challenged intragastrically with C. albicans 1 hour prior to the burn in a ketoconazole - candida treated group. Tissues were harvested from the mesenteric lymph node, liver, spleen and cecum on the 1st and 4th postburn days and cultured on Sabouraud dextrose agar and then stained with periodic-acid Schiff (PAS) to observe the translocation of C. albicans. All findings were compared with those of each control(40% scald burn) and candida treated(gavage with C. albicans+40% scald burn) group. The results were as follows ; 1. There was no translocation of C. albicans to mesenteric lymph node or other organs in the control group. In the ketoconazolee-candida treated group, C. albicans were found in only the mesenteric lymph node on the l st postburn day, but they tanslocated to the liver and spleen on the 4th postburn day. In the candida treated group, C. albicans were observed in all examined organs on the 1st postburn day and the rate of translocation incresed on the 4th postburn day. The translocation of C. albicans in the candida treated group increased more significantly than that of the ketoconazole-candida treated group. 2. On microscopic examination, C. albicans seems to have passed through the intestinal mucosal barrier and then they were phagocytized by macrophages in the laminal propria. Also most C. albicans which had infiltrated into the other organs were phagocytized by macrophages. In the candida treated group, C. albicans had infiltrated into the organs at a greater rate than that of the ketoconazole-candida treated group. With these result, ketoconazole reduced the translocation rate of enteric C. albicans in major burn injures. But more study will be necessary to determine the relationship between the degree of translocation.
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국소 조직괴사를 동반한 진행된 유방암 환자에서 광배근피판을 이용한 재건 치험례
정상설,임풍,유결,조성필,안상태 大韓成形外科學會 1993 Archives of Plastic Surgery Vol.20 No.6
In the far advanced breast cancer with wide local destruction and metastasis to the regional lymph node and distant organs, curative surgery is difficult and complete remission is rare. As these patients have relatively short survival periods of only several months or years, the majority of surgeons have given up surgery and inclined to conservative or wound dressing. The patient are suffered from serious wound complications such as profuse discharge, foul odor, intractable pain, chest wall invasion even in the fair general condition. We experienced three cases of far advanced breast cancer with extensive local tissue necrosis and distant metastasis. We treated the breast necrosis with wide resection and immediate reconstruction using Latissimus dorsi musculocutaneous flap. During the follow-up periods from 6 months to lyear, all three patients were freed from daily wound treatment and intractable pain. As a conclusion, an aggressive surgical treatment of local tissue necrosis in the far advanced breast cancer may improve the quality of life, physical and mental health, of the patients.
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이인주,임풍,곽청근,위성신,조성필,이희영 大韓成形外科學會 1995 Archives of Plastic Surgery Vol.22 No.1
Trochanteric pressure sores often present with minimal skin involvement and extensive bursae formation. The mobile nature of the trochanter predisposes these ulcerations to extensive undermining and hip infection such as osteomyelitis and pyarthrosis. In these patients, debridement, cutrettage, and soft-tissue coverage frequently fails to control infection and results in failure of reconstruction. Resection of femoral head and neck, and wide debridement of the hip joint like Girdlestone operation is required for this complicated condition. Trochanteric or ischial sores complicated by infection of hip joint are rarely reported. From 1989 to 1993 five paraplegic patients with trochanteric sores were found to have infection of ipsilateral hip joint. All patients had multiple sores and clinical symptoms of fever and chillness. Among them, four patients were successfully treated by Girdlestone operation and coverage of skin defects with tensor fascia latae flap. One patient was treated by curettage and drainge. For the definitive treatment of trochanteric sores complicated by hip infection, it is important to evaluate clinical symptoms and radiologic findings and to resect proximal femur as well as infected soft tissues.
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