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수용성 약물인 세파클로를 함유하는 젤라틴 마이크로캅셀의 제조 및 약물 방출특성
조성완(Seong Wan Cho),박종화(Jong Hwa Park),박준상(Jun Sang Park),장정수(Joung Soo Jang),최영욱(Young Wook Choi) 대한약학회 1997 약학회지 Vol.41 No.1
In order to formulate a controlled release system for oral drug delivery, the microcapsules were prepared in w/o emulsion containing cefaclor as a water-soluble model drug by the method of interfacial polycondensation. Gelatin wis selected as a suitable polymer for interfacial polycondensation. Gelatin solution containing drug was emulsified in an organic phase under mechanical stirring. After emulsification, terephthaloyl chloride was added as cross linking agent, followed by mechanical stirring, washing and drying. Physical characteristics of microcapsules were investigated by optical microscopy, scanning electron microscopy and particle size analysis. Mean particle sizes of gelatin microcapsules were, in the range, of about 20~50mcm. The microcapsules were in good apperance with spherical shapes before washing, but were destroyed partially after washing and drying, even though some microcapsules were still maintained in their shapes. Contents of cefaclor in the microcapsules were calculated by UV spectrophotometry after 3 days extraction with pH 4 carbonate buffer solution. The effects of cross linking time. pH. concentration of cross-linking agent, and temperature on drug release kinetics have been discussed extensively.
바난 정 ( 세프포독심 프로세틸 100mg ) 에 대한 포독수 정의 생물학적 동등성
조성완(Seong Wan Cho),이지혜(Ji Hye Lee),송일용(Il Yong Song),이상길(Sang Kil Lee),차영주(Young Joo Cha),최영욱(Young Wook Choi) 한국약제학회 1999 Journal of Pharmaceutical Investigation Vol.29 No.3
Bioequivalence study of two cefpodoxime preparations, the test drug (Banan^ⓡ: Hanil Pharmaceutical Co., Ltd.) and the reference drug (Podox^ⓡ: Chong Kun Dang Pharmaceutical Co., Ltd.), was conducted according to the guidelines of Korea Food and Drug Administration (KFDA). Sixteen healthy male volunteers, 23.81±2.13 years old and 63.34 ±4.84 ㎏ of body weight in average, were divided randomly into two groups and administered the drug orally at the dose of 200 ㎎ as cefpodoxime proxetil in a 2×2 crossover study. Plasma concentrations of cefpodoxime were analysed by HPLC method for 12 hr after administration. The AUC_(0-12hr) was calculated by the linear trapezoidal rule method, The C_(max) and T_(max) were compiled directly from the plasma drug concentration-time data. Student`s t-test indicated no significant differences between the formulations in these parameters. Analysis of variance (ANOVA) revealed that there were no differences in AUC, C_(max), and T_(max) between the formulations. The apparent differences between the formulations were far less than 20% (e.g., 4.31, 1.99 and 4.30% for AUC, C_(max), and T_(max), respectively). Minimum detectable differences (%) between the formulations at α = 0.05 and 1-β=0.8 were less than 20% (e.g., 13.89, 13.88, and 16.97% for AUC, C_(max), and T_(max), respectively). The 90% confidence intervals for these parameters were also within ±20% (e.g., -5.58∼14.20, -7.89∼11.88, and -7.78∼16.38% for AUC, C_(max), and T_(max), respectively). These results satisfied the bioequivalence criteria of KFDA guidelines, indicating that the two formulations of cefpodoxime were bioequivalent.
최성업(Choi, Sung-Up),조성완(Cho, Seong-Wan) 한국산학기술학회 2013 한국산학기술학회논문지 Vol.14 No.12
본 연구에서는 액상 형태인 콜린알포세레이트를 알루미늄마그네슘규산화합물에 흡착시켜 고형의 제형화가 가능한 콜린알포세레이트를 함유하는 정제의 제조하고 평가하였다. 정제는 콜린알포세레이트 대비 흡착제의 비율을 달리하여 제조하고, 물리적 특성 및 용출률을 조사하였다. 정제의 타정성과 용출률을 고려할 때 흡착제는 주성분 대 비 50∼75%가 적절하였다. 주성분 대비 62.5%의 흡착제를 사용한 제제에서 정제의 경도, 붕해, 마손도 시험, 용출곡 선하면적 비율 결과가 가장 우수하였다. 알루미늄마스네슘규산화합물은 액상 약물의 고형화 설계 시 좋은 소재가 될 수 있을 것이다. The aim of this study was to prepare and evaluate tablets containing liquid choline alphoscerate, which is capable of being formulated as a solid dosage form by the adsorption of magnesium aluminum silicate. The tablets were prepared with various absorbent to choine alphoscerate ratios. The physical properties and the dissolution rate were investigated. Considering the tabletting and dissolution rate, the formula scontaining 50-75% absorbent were adequate in the tested formulations. The 62.5% absorbent formula showed superior results with the tests of hardness, friability, disintegration time, and the ratio of dissolution area under the curve. Overall, magnesium aluminum silicate can be an alternative additive to a liquid drug.
박종한(Jonghan Park),조성완(Sung Wan Cho) 대한노인정신의학회 1997 노인정신의학 Vol.1 No.1
Etiological classification of a syndrome is most warranted. However, it is very difficult in the case of dementia because many research activities are still being made about the cause of degenerative dementias. In the current paper, clinical aspects and pathological findings were also con-sidered in the etiological classification. Prevalence and annual incidence of dementia are 5-15% and 1.5-2.0% in the elderly over 65, respectively. Old age, female sex, genetic background, lower education, ethnicity or geographical difference, and head trauma seem to be risk factors for developing dementia. Urinary and fecal incontinece, extrapyramidal symptoms, primitive reflexes, psychotic symptoms, and cognitive decline seem to adversely affect on the mortality, while social class, age at onset, depressive symptoms, aggressive behavior, wandering, increased appetite, increased sexual behaviors, and early diagnosis do not.