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말단비대증 환자의 혈중 프롤락틴 수치와 면역조직화학염색과의 상관관계
강보현 ( Bo Hyun Kang ),정인경 ( In Kyung Jeong ),조덕신 ( Duck Shin Cho ),강한욱 ( Han Wook Kang ),김형훈 ( Hyung Hoon Kim ),김범진 ( Beom Jin Kim ),민태훈 ( Tae Hoon Min ),손준성 ( Jun Seong Son ),홍성노 ( Sung No Hong ),이춘영 대한내과학회 2003 대한내과학회지 Vol.64 No.2
목적: 말단비대증은 대부분 성장호르몬 분비 뇌하수체 선종에 의한 것으로 35%에서 고프롤락틴혈증이 동반된다고 알려져 있다. 저자들은 말단비대증 환자의 뇌하수체 조직의 면역조직화학염색 소견과 혈중 호르몬 수치를 비교하여 이들간에 어떠한 관계가 있는지 알아보고자 하였다. 방법: 1998년 8월부터 2001년 5월까지 말단비대증 진단 하에 뇌하수체 종양 제거수술을 받은 환자 28명(남자:여자=18:10, 평균연령: 41세)을 대상으로 하였다. 혈중 기저 성장 Background: Acromegaly occurs by excessive secretion of growth hormone and more than 99% of cases are caused by a growth hormone-secreting pituitary adenoma. Pituitary adenomas expressing multiple immunoreactivities are common. We assumed that the pituita
조덕신,이병재,민태훈,강보현,김형훈,이병완,최동철 대한내과학회 2002 대한내과학회지 Vol.63 No.4
The hemolytic uremic syndrome (HUS) is a clinical syndrome defined by the presence of thrombocytopenia, microangiopathic hemolytic anemia and acute renal failure with or without a clinically apparent etiology. The conventional treatment of choice is plasmapheresis as a first-line therapy. Most patients respond to plasmapheresis whereas some patients are refractory to the therapy. The second-line therapy is not well established although various therapies such as steroid, vincristine, intravenous immunoglobulin have been suggested. The intravenous immunoglobulin therapy in refractory hemolytic-uremic syndrome have rarely been successful in complete remission. We report a case of refractory HUS in a 48 year-old man who developed hemolytic anemia, thrombocytopenia, acute renal failure and ischemic retinopathy. The patient was refractory to plasmapheresis as a first-line therapy. The patient received intravenous immunoglobulin therapy as a second-line therapy after 8 days of plasmapheresis, which subsequently resulted in a complete remission of refractory HUS. The complete remission using immunoglobulin in HUS has not been previously reported in Korea.