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이미숙,남궁형욱,김영주,손인자,조남춘 한국병원약사회 1997 병원약사회지 Vol.14 No.4
The stability of a dexamethasone disodium phosphate in suspension was studied. Suspensions of dexamethasone disodium phosphate were prepared from commercially available amples (Dexamethasone suspension Ⅰ) and from bulk powder (Dexamethasone suspension Ⅱ) to yield a suspension with a theoretical dexamethasone disodium phosphate concentration of 0.5㎎/㎖. The suspension was divided into portion and stored in plastic bottles under fluorescent light or in light - protective vinyl package at room temperature (25±1℃) or refrigerated temperature(4±1℃) for 6 months. The concentration of dexamethasone disodium phosphate in the samples was determined by a stability - indicating High Performance Liquid Chromatographic (HPLC) assay at 0, 1, 2, 4 and 6 months. Also at these times, the pH of the sample was measured and the samples were inspected for evidence of the color, odor and microbial growth. The concentration of dexamethasone disodium phosphate in the samples remained more than 90% of the initial concentration throughout the study period. No important change of the color and odor in the samples were noted throughout the study period. No important change in the pH of the samples were noted for 6 months under all storage conditions. Visible evidence of microbial growth was noted in dexamethasone suspension Ⅱ stored at room temperature on 4 months. This extemporaneous suspension of dexamethasone disodium phosphate prepared form bulk powder and from commercially available injections is stable for at least 4 months when stored in light - protective vinyl package at refrigerated temperature.
당뇨병, 췌장질환 환자에 있어서의 TPN 투여시 클루코오즈 및 인슐린 투여량과 혈당 조절에 관한 조사 연구
이주연,이영필,김호순,박경호,조남춘,신완균 한국병원약사회 1996 병원약사회지 Vol.13 No.1
Hyperglycemia is main problems in diabetes or pancreatic disease patients on Total Parenteral Nutrition (TPN) therapy. The Insulin therapy is the first artifact in hyperglycemia by admixturing insulin to TPN solution. So, the purpose of our study is to calculate the insulin requirement for optimal blood glucose control. The amount of glucose intaked and insulin administered during TPN therapy was studied by reviewing chart of patients in diabetes and pancreatic disease who had received TPN from 1994. 1 to 1995. 12 in SNUH retrospectively. Total 34 cases are divided into well-controlled level group(A:16 case) and non-controlled level group(B:18 case). Well-controlled level group means that its blood glucose level is maintained between 100-230 ㎎/㎗ during TPN administration. Both group is subdivided into IDDM, NIDDM and pancreatic disease. We calculated Insulin and Glucose ratio (I/G) in IDDM and NIDDM of well-controlled level group. The I/G values of IDDM group and NIDDM are 0.20±0.033 and 0.077±0.01 respectively. This result shows that IDDM's insulin requirement is larger than NIDDM's as expectedly(P<0.05). And when stress factor(e.g. surgery, infection) is considered, it was found that stress factor affects blood glucose control.
류마티스 환자를 대상으로 한 NSAID제제의 부작용 비교
조윤정,문순란,박경호,조남춘,송영욱 한국병원약사회 1998 병원약사회지 Vol.15 No.2
Comparative side effects of NSAIDs, such as salsalate, choline magnesium trisalicylate, fenoprofen, naproxen, aspirin and indomethacin was assessed using the Stanford Toxicity Index (STI) consisting of weighted symptoms, laboratory abnormalities in 100 rheumatoid arthritis patients from out patient clinic of Seoul National University Hospital. All patients were enrolled in one physician who is recording any side-effects of drug on patient's medical chart. Two pharmacists evaluated the randomly selected patient's medical chart, and checked the recording of side effects, such as dizziness, pruritus, rash, edema, tinnitus, hearing difficulty, nausea, upper abdominal pain, constipation, dyspepsia, ear fullness, epigastric fullness, mild liver toxicity, hyperuricemia and headache. From the results of this study, it was found that common side effects were tinnitus, hearing difficulty and ear fullness for salsalate, gastrointestinal disturbances for choline magnesium trisalicylate, fenoprofen and naproxen, and gastrointestinal disturbances and hearing difficulty for aspirin, and headache for indomethacin. Scores of STI ranged from 0.32 for aspirin to 2.56 for salsalate. Also occurrence rate of side effects of NSAIDs was evaluated according to period of drug administration. It was noted that most of side effects were common within 1 year of drug administration, but naproxen and indomethacin had even distributional occurrence of side effects according to period of drug administration.
김유은,서성연,한현주,이병구,조남춘 한국병원약사회 1999 병원약사회지 Vol.16 No.3
Since the medical insurance has come to cover up to 90-days at one time in outpatient base in Dec. 1995, the long-term medication(over 30days) has been increased abruptly and rapidly. The object of this study is to determine the influence of outpatient long-term medication at one visit on filling the prescription, dispensing and administration and to enlarge the effectiveness of dispensing and administration in outpatient pharmacy. We compared the data related the long-term medication in 1998 with those in 1996 in Seoul National University Hospital. The number of order day, incidence and frequency of long-term medication were reviewed in different medical department, disease group and each diseased respectively. The average waiting time for medication per year was also investigated to recognize the influence on doing dispensing and administration directly. In basic, we figured out the average number of outpatients for one day, total amount of drug expense for every outpatient and total amount of dispensing fee per year from 1996 to 1998. The medication over 60-days was most increased, cardiovasular diseased and hypertension is most frequent in long-term medication. The average number of outpatient for one day has been increased in every year. Although the long-term medication was increased continuously at much rate, the average waiting time for medication has been shorter by adopting alternative measures(i.e automatic transport system, diverse preliminary preparation). The result of this study indicates that increased number of long-term medication caused increased load of dispensing, increased number of first-coming patients, increased income of the hospital. In the viewpoint of patients, they do not have to visit clinic as often as before, but the necessities of medication counselling for drug adverse reaction and management of noncompliance due to the long-term medication are increased as much as.