부신피질호르몬이 혈장 Erythropoietin 활성에 미치는 영향

조규철,이상복,이덕희,이종화,Cho, Kyu-Chul,Lee, Sang-Bok,Lee, Duck-Hee,Lee, Jong-Hha 대한약리학회 1974 대한약리학잡지 Vol.10 No.2

This study was undertaken to determine if the adrenocortical hormone was concerned on erythropoietic function, especially on the production of erythropoietin in the kidney. Erythropoietin titers in plasma measured in each group of mice: 1) hypertransfused mice treated with the plasma of rats pretreated with hydrocortisone, dexamethasone, fludrocortisone and DOCA 2) hypertransfused mice treated with the plasma of the rat pretreated with aldosterone antagonist and adrenocortical hormone concomitantly. Erythropoietin level in plasma were measured by the modification of DeGowin's method. The results of the experiment were summerised as follows: 1) No significant changes of erythropoietin titers were observed in hypertransfused mice treated with the plasma of rats pretreated with hyrocortisone and dexamethasone respectively. 2) Erythropoietin titers increased significantly in hypertransfused mice treated with the plasma of rats pretreated with fludrocortisone and DOCA respectively, compared with control. 3) No significant changes of erythropoietin titers were observed in hypertransfused mice treated with the plasma of rats pretreated with spironolactone and triamterene respectively, compared with control. 4) Erythropoietin titers slightly increased in hypertransfused mice treated with the plasma of rats pretreated with spironolactone or triamterene, and fludrocortisone concomitantly and also with spirolactone or triamterene and DOCA.

연구발표논문초록 ( 흡착 ) : 입상 활성탄에 의한 용존 (溶存) Cu (Ⅱ) 의 흡착

조규철 (학),이종집 (정),조병린 (정) ( Kyu Chul Cho,Jong Jib Lee,Byung Rin Cho ) 한국화학공학회 1987 춘계학술발표회 Vol.- No.-

Spring Framework를 활용한 학생 교육프로그램 참여 관리 시스템 개발

조규철(Cho Kyu Cheol),송우현(Song U Hyeon),이인철(In Chul Lee) 한국컴퓨터정보학회 2018 한국컴퓨터정보학회 학술발표논문집 Vol.26 No.2

대부분의 대학생들은 재학기간 중에 학교에서 운영되는 교육프로그램, 자원봉사, 어학연수, 동아리활동 등 다양한 경험을 하게 된다. 최근에는 학교에서 운영하는 교육프로그램이 더욱 다양해지고 많은 학생들이 참여하고 있다. 하지만 학교에서는 학생들이 어떤 활동을 했는지 효율적으로 관리하고 참여 학생의 적극적인 참여율 유도가 필요가 있지만, 이를 효율적으로 관리하는 것은 어려운 일이다. 본 연구는 학교에서 시행중인 다양한 프로그램들에 대하여 학생들이 참여함에 따라 학생들의 참여현황을 조사하여 관리하고 참여율과 학과별 통계를 Dashboard로 열람할 수 있는 프로그램을 개발하여 운영하였다. 교육 참여 관리 시스템을 활용함으로써 담당자의 업무 효율을 기대할 수 있고 체계적인 학생들의 교육 프로그램을 효율적으로 모니터링하고 관리할 것으로 기대된다.

An Efficient Broadcast scheme for disseminating Emergency Messages in Urban Vehicular Ad-Hoc Networks

Lee Kyu Chang(이규창),Cho Keu Chul(조규철),Li Jilong(이길용),Han Ki Jun(한기준) 한국통신학회 2013 한국통신학회 학술대회논문집 Vol.2013 No.1

If an accident vehicle propagates emergency messages to other vehicles close to it, the other drivers may realize and avoid the accident spot. In this letter, we propose a broadcast scheme to propagate emergency messages fast in urban VANETs (Vehicular Ad-Hoc Networks) with the help of GPS (Global Position System). In our scheme, a transmitting vehicle chooses the farthest node as the next relay vehicle to propagate emergency messages. And, we suggest an algorithm for intersection recognition and SCF (Store-Carry-Forward) task by taking advantage of periodic hello packets to reduce the propagation time and enhance the delivery ratio.

도심의 차량 네트워크에서 긴급 메시지 전파를 위한 효율적인 브로드캐스트 기법

이규창(Kyu-chang Lee),한기준(Ki-jun Han),조규철(Keu-chul Cho),백영미(Young-mi Baek),김준형(Jun-hyung Kim) 한국통신학회 2013 韓國通信學會論文誌 Vol.38 No.7(융합기술)

Effect of Bradykinin on Oxygen Consumption in the Distal Tubule and Cortical Collecting Tubule of Rat

이석용,조규철,Lee, Seok-Yong,Cho, Kyu-Chul The Korean Society of Pharmacology 1990 대한약리학잡지 Vol.26 No.2

Kallikrein-kinin계는 신장의 혈류역학과 수분 및 전해질 배설의 조절자로서 역할을 하는 것으로 알려져 있다. Kallikrein-kinin계의 유효한 펩타이드중 하나인 bradykinin(BK)을 신동맥에 주입시 전해질 배설이 증가하는데 이 작용이 신혈류역학적 변동에 기인하는지 또는 신세뇨관의 전해질 운반에 대한 직접적인 작용에 기인하는지 아직 확실치 않다. 따라서 본 연구에서는 원위세뇨관(DT)과 피질집합관(CCT)에서의 전해질운반 의존성 산소소비에 대한 BK의 영향을 관찰하였다. BK$(0.1\;{\mu}M)$은 DT과 CCT의 산소소비를 유의하게 감소시켰으며 이 작용은 Na부재시 나타나지 않았고 ouabain전처치에 의해 차단되었다. 또한 이 작용은 mepacrine에 의해 유의하게 차단되었으며 indomethacin에 의하여는 차단되지 않았다. 이상의 결과는 BK이 DT과 CCT에서 Na운반과 관련한 산소소비를 억제시키며 이 작용에는 prostaglandin들이 관여하고 있지 않음을 시사한다. Infusion of bradykinin (BK) into the renal arteries increases sodium excretion. However, it is not clear whether natriuresis results from the renal hemodynamic effects or from the direct effect on renal tubular sodium transport. Therefore, we examined the effects of BK on the transport-dependent oxygen consumption in the distal tubule (DT) and cortical collecting tubule (CCT) of deoxycorticosterone-treated rats. BK inhibited oxygen consumption in a dose-dependent way with a maximal reduction at $0.1\;{\mu}M$ BK. The inhibitory effect of BK was not present in the absence of sodium or in the presence of ouabain (1 mM). These data imply that the inhibitory effect of BK is restricted to the sodium transport-dependent oxygen consumption. We also investigated the relationship between the effect of BK on oxygen consumption and arachidonic acid metabolism. Mepacrine $(10\;{\mu}M)$, an inhibitor of membrane phospholipases, prevented the inhibitory effect of BK, but indomethacin (0.5 mM) didn't. These results suggest that BK decreases the sodium transport-related oxygen consumption in the rat DT and/or CCT, and that it may be mediated by products of enzymes other than cyclooxygenase.

Conticosteroids 점안이 안압 및 Acetazalamide 의 안압하강작용에 미치는 영향

백운상 , 조병헌 , 조규철 ( Un Sang Paek , BYung Heon Cho , Kyu Chul Cho ) 대한안과학회 1974 대한안과학회지 Vol.15 No.1

Acetazolamide 의 Carbonic Anhydrase 활성 억제 작용에 대한 Testosterone 의 영향

장동원,이상복,조규철,Chang, Dong-Won,Lee, Sang-Bok,Cho, Kyu-Chul 대한약리학회 1975 대한약리학잡지 Vol.11 No.2

This study was carried out to observe the effect of testosterone on carbonic anhydrase inhibiting action of acetazolamide. Carbonic anhydrase activities in the kidneys of mice were measured by Philpot and Philpot method(1936) at 30, 90 and 150 minutes after intravenous administration of saline(0.5 ml/10 g) or acetazolamide (0.25 mg/10 g) in mice pretreated with testosterone (0.1 mg/10 g). The changes in volume and pH of urine as well as those in urinary electrolytes, such as $Na^+,\;K^+\;and\;Cl^-$ were measured at 15 minutes interval for 150 minutes in the rabbit pretreated with double administrations of testosterone(10 mg/kg), 1 hour and 18 hours, prior to the administration of acetazolamide (10 mg/kg). The results were as follows: 1. Carbonic anhydrase activities in the kidneys of mice of testosterone-pretreated groups were significantly higher than those of acetazolamide-treated group at 30 minutes. No significant changes of carbonic anhydrase activities were observed in testosterone-pretreated groups compared with saline-treated groups. 2. Combined administrations of acetazolamide and testosterone exhibited higher carbonic anhydrase activity than those group of acetazolamide alone in the kidney of mice through observed period of 150 minutes. 3. There were no significant changes in the excretion rate of urine and urinary electrolytes in the group of rabbits with testosterone administerone alone. Urine volume as well as $Na^+\;and\;Cl^-$ excretion rates in the combined treated group of acetazolamide and testosterone were significantly lower than that of acetazolamide group throughout experimental period except 15 minutes after drug administration at the time transient increase was shown. 4. Generally lower $K^+$ excretion rate was observed in the combined treated group of acetazolamide and testosterone compared with the single acetazolamide-treated group and the testosterone-pretreated group shows lowest excretion rate of potassium.

Hydrocortisone의 신동맥 주입이 acetazolamide 및 aminophylline의 이뇨작용에 미치는 영향

이종화,이덕희,조규철,Lee, Jong-Hha,Lee, Duck-Hee,Cho, Kyu-Chul 대한약리학회 1974 대한약리학잡지 Vol.10 No.2

This study was carried out to observe the direct effect of hydrocortisone on renal function by infusing it into a renal artery. Hydrocortisone (5mg/kg) or saline (0.5 ml/kg) was infused directly into the left renal artery of the rabbit, the right kidney was left intact to serve as a control for general action of acetazolamide (10 mg/kg) or aminophylline (10 mg/kg), which was administered intravenously 30 minutes after the direct infusion of pretreated drugs (hydrocortisone or saline). The changes of urine volume, pH, urinary excretion rates of $Na^+,\;K^+\;and\;Cl^-$, and the clearances of inulin and PAH were measured at an interval of 10 minutes for half an hour after the direct infusion of hydrocortisone or saline, and for one hour after intravenous administration of acetazolamide or aminophylline. The results of the experiment were as follows: 1. Significant changes in urine volume and urinary electrolytes (excreted rates of $Na^+,\;K^+\;and\;Cl^-$) were observed in the hydrocortisone-infused group 10 minutes after the administration of acetazolamide, compared with the saline-infused group. Especially, the effect was more potent on the infused (left) side than on the contralateral (right) side. 2. Significant changes in urine volume and urinary electrolytes were also observed in all the aminophylline-treated groups, but no remarkable difference was noticed between the hydrocortisone-infused group and the saline-infused group, nor between the left and right sides. 3. No signicant changes in the clearances of inulin and PAH were in the infused (left) side of all the experimental groups, as compared with the contralateral (right) side. From the above results, it is obvious that hydrocortisone infused into a renal artery exerts diuretic action when administered in combination with acetazolamide, and the mechanism of action rests not on its hemodynamic change for renal blood flow, but on the potentiation of carbonic anhydrase inhibiting action. However, the exact mode of action remains yet to be clarified.

Effects of Loop Diuretics on Guanylate Cyclase in Rat Medullary Thick Ascending limb of Henle's Loop

이석용,노경식,김옥녀,이상복,조규철,Lee, Seok-Yong,Ro, Kyung-Sik,Kim, Ok-Nyu,Lee, Sang-Bok,Cho, Kyu-Chul The Korean Society of Pharmacology 1989 대한약리학잡지 Vol.25 No.1

흰쥐의 헨레고리 수질 비후상행각에서의 전해질 재흡수와 cyclic GMP와의 관계를 알아보고자 수질비후상행각의 guanylate cyclase에 대한 furosemide와 ethacrynic acid의 영향을 관찰하였다. 또한 이들 작용과 prostaglandin의 상관관계를 알아보고자 guanylate cyclase에 대한 고효능이뇨제(furosemide, ethacrynic acid)와 cyclooxygenase 억제제들과의 상호작용을 함께 관찰하였다. furosemide와 ethacrynic acid는 guanylate cyclase의 활성을 현저히 증가시켰으며 이 증가작용은 aspirin이나 indomethacin에 의해 차단되지 않았다. arachidonic acid는 furosemide의 guanylate cyclase 활성증가작용을 유의하게 증강시켰다. 이들의 결과는 furosemide와 ethacynic acid가 직접적인 guanylate cyclase 활성촉진작용을 가지고 있으며 또한 furosemide는 prostaglandin을 경유한 간접적인 guanylate cyclase 활성 촉진작용을 가지고 있음을 나타낸다. 또한 수질 비후상행각에서의 전해질 재흡수에 cyclic GMP가 관여할 가능성을 시사한다. To determine the relation between cGMP and ion reabsorption in rat medullary thick ascending limb of Henle's loop (mTALH) the effects of loop diuretics, furosemide and ethacrynic acid, on the guanylate cyclase of rat mTALH were investigated. The interactions between loop diuretics and cyclooxygenase inhibitors, aspirin and indomethacin, on guanylate cyclase of rat mTALH were also investigated. Furosemide and ethacrynic acid increased guanylate cyclase activity and these effects were not inhibited by aspirin or indomethacin. Arachidonic acid potentiated the stimulatory effect of furosemide on guanylate cyclase. These results suggest that furosemide and ethacrynic acid activate guanylate cyclase directly, and in addition, furosemide affects indirectly via prostaglandin. The reabsorption of sodium chloride may be, at least partially, controlled by cGMP in mTALH.