광범위한 분포를 보인 다발성 Becker 모반

조광열(Gwang Yeol Joh),이애영(Ai Young Lee),윤재일(Jai Il Youn),이유신(Yoo Shin Lee) 대한피부과학회 1984 대한피부과학회지 Vol.22 No.6

Becker's nevus or Becker's melanosis is a distinct clinical entity in which epimal thickening may be minimal and hairiness and pigmentation obvious. 1Ne report a case of 14-year-old female suffering from Beckers melanosis with multiple and extensive skin lesions. The electron microscope revealed that the melanocytes were bulky with increased melanogenesis and an increased number of melanosomes was found in the keratinocytes. In addition, a large number of melanosomes were seen individually in the keratinocytes.

자외선 조사에 의한 생쥐 피부에서의 일광화상 세포의 정량적 변화

조광열(Gwang Yeol Joh),윤재일(Jai Il Youn),이유신(Yoo Shin Lee) 대한피부과학회 1986 大韓皮膚科學會誌 Vol.24 No.1

In this study, a total of 115 ICR male albino haired mice were used and divided into two groups(A & B) for experiment. In group A(65 mice), quantiatation of sunburn cell(SBC) production and its distribution according to the time course after ultraviolet irradiation was measured. In group B(50mice), quantitation of dose-response experiments for SBC production after ultraviolet irradiation was measured. The results were as follows: ]. SBCs were recognized by 2 hours after irradiation. There was a tendency to increase from 2 hours to 24 hours and decrease from then to l week after irradiation, 2. The increase of SBCs in lower epidermis 2 hours io 8 hours after exposure and in upper epidermis 24 hours after irradiation were statistically significant (p<0. 05). SBG number in all layers declined from 36 hours to 1 week after exposure. 3. The linear relationship which observed(y=8.09+0.85x, R=0.87) suggests a dose-response relationship between UVB dose and SBC number.

제 III 형 일광담마진 2예

조광열(Gwang Yeol Joh),윤재일(Jai Il Youn),이유신(Yoo Shin Lee) 대한피부과학회 1985 대한피부과학회지 Vol.23 No.3

Solar urticaria is an uncommon disorder characterized by rapid development of urticarial reaction in areas of skin exposed to nonizing electromagnetic radiation. Herber and Baer classified solar urticaria into eight types on the basis of action spectrum and passive or reverse passive transfer ability. We report two cases of type ]g solar urticaria which were activated by visible light and negative in both passive and reverse passive transfer test.

Kitamura 망상 선단색소침착증 2예

조광열(Gwang Yeol Joh),윤재일(Jai Il Youn),이유신(Yoo Shin Lee) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.1

We report two familial cases of reticulate acropigmentation of kitamura in 20-year-old male and 29-year-old female patients in which reticualte, brownish, slightly depressed pigmentation developed on acral parts of extremities and subsequently extended proximally. Characteristic pits and breaks on palms and soles were noted. Histologic findings revealed epidermal atrophy and enlongation of rete ridges with large amounts of melanin. Electron microscopic findings showed increased melanogenesis in melanocytes and numerous melanosomes and melanosome complex in keratinocytes.

Ota 모반의 임상적 고찰 및 피부 이외의 부위의 색소침착

조광열(Gwang Yeol Joh),은희철(Hee Chul Eun),이유신(Yoo Shin Lee) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.1

This study was undertaken to elucidate extracutaneous hyperpigmentation of nevus of Ota by analyzing the 70 patients who visited Cryosurgery Clinic in Seoul National University Hospital between January 1984 and March 1985 This results were as follows: 1. The age of onset showed two peaks: the first one was at birth or soon after birth; 27 cases(38. 6%) and the second une was between 11 and 17 years; 37 cases (45. 7%). 2 Seventy cases were classified by Taninos method: 15.7% was type I a, 27. l% type I b, 28. 6% type Il, 20. O% type g and 8. 6% type IV 3.Fifty two out of 70 cases who were examined at the department of ophtha1rnology: pigrnentation of sclera was observed in 29 cases(55. 8%.), of conjunctiva in 18 cases(34.6%), of uveal tract in 14 cases(26. 9A), of fundus in 14 cases (26. 9%) and of optic papilla in 2 cases(3. 8%). 4 Fifty two out of 70 cases who were examined at the department of Otorhinolaryngology. pigmentation of tympanum was observed in ]0 cases(23, 8%,), of nasal mucosa in 6 cases(14. 3p,), of oral mucosa in 5 cases(11, 9%), of external auditory canal in 4 cases(9 5%) and of pharynx in 1 case(2. 4%,)

모반양 기저세포암 증후군 2예

조광열(Gwang Yeol Joh),남종택(Ki Ho Kim),김기호(Jong Taik Nam),김영수(Young Soo Kim),이봉구(Bong Ku Lee) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.6

Nevoid basal cell carcinoma syndrome is inherited as an autcsonal dominant trait with a high degree of penetrane and variable expressivity. The mair features are basal cell carcinoma. jaw cysts, skeletal anornalies, ectopic calcifications and palmoplantar pits. We report varous clinical ma.nifestations in brother and sister, wnich are jaw cyst,, bifid rib, shortened fourth metacarpals, ectopie calcification, palrnoplanar pits and basal cell carcinoma, Microscopically, histologic patterns of basal cell cacinomas are superficial, nodulocystic, keratotic, pigmented, adenoid and follicullar nevoid. Lange numbers of basal cell carcinomas were electrodessicated and curetted under general,nesthesia. (Kor J Dermatol 1992;30(6):951-957)

멜라닌을 함유한 에크린 한공종

조광열(Gwang Yeol Joh),이애영(Ai Young Lee),윤재일(Jai Il Youn),이유신(Yoo Shin Lee) 대한피부과학회 1985 대한피부과학회지 Vol.23 No.1

It has been generally assumed that eccrine poroma ariees from acroayringium, epidermal sweat duct unit. One of the characteriatics of thie structure is abaence of melanocytes and melanin granules among ite cells. Hmvever, a cornplete abeence of melanocytes and melanin granules in eccrine poroma is not invariable and a few reparts of such an occurrenee were presented, We report a case of eccrine poroma on the area below lateral malleolus af left foot. Microscpically melanin granules, confirmed by the use of Fontana Masson stain, were found in some of the tumor cells.

광선 치료를 시행한 일광 담마진

조광열(Gwang Yeol Joh),윤재일(Jai Il Youn),이유신(Yoo Shin Lee) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.3

We report a case of solar urticaria being activated by both UVA and visible radiation and positive in passive transfer test by visible light, which was treated with sunlight and UVA radiation. A short course of treatment with sunlight produced no benificial effect. UVA phototherpy produced a rnarked increase in the minirnal urtication dose by UVA but there was no increased tolerance to sun exposure.

외배엽 기원 세포암에서의 Metallothionein 발현의 의의

김기호,이민수,조광열 ( Ki Ho Kim,Min Soo Lee,Gwang Yeol Joh ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.1

Background: Metallothioneins(MTs) are ubiquitous low molecular weight cytosolic proteins with high contents of cystein that xhibit a selective binding affinity for zinc, copper and other group II heavy metal ions. In additi~on to the sequestration function and detoxification action, MTs probably participate in the cellirlar protection against. ionizing radiation and alkylating agent cytotoxicity and in cellular pn:liferation. Qbject : The objective of this study was to evaIuate the expression of MTs and to clarify t.heir role in carcinogenesis and/or biological behaviour in the neoplasms of ectoderrnal origin. Methods : We performed immunohistochemical studies on the surgical specimens of rnalignant rnelanoma and squamous cell carcinoma and basal cell carcinoma. The results were compared with the normal skin and mu osa and hair t,issues and raf't-on culture tissues of skin and mucosal keratinocytes. Results . 1) MTs were strongly expressed in epidermal basal cells of the normal skin and raft-on cultured artificial skin They were also rnore weakly expressed in epithelial basal cells of the normal mucosa and raft on cultured artificial mucosa and in matrix cells of the normal hair. 2) In rnalignant melanoma, MTs were meaningfully expressed, i.e., a strong expression was seen in the lesions showing a rapid vertical growth phase with fatal out,comes, but a weak expression in the cases whose precursor lesions were thought as dysplastic nevi, compared to the negative finding of norrnal melanocyt,es. The strong expression in a case of congenit.al rnelanocyt.ic nevus is considered as the activation of nevoid melanocytes. 3) MTs were weakly expressed in squarnous cell carcinoma with a diffuse aattern within the tumor mass. St,rong expression of MTs was particularly apparent in the poorl. differentiated squamous cell carcinoma and at the growing border of well differentiated squamous cell carcinoma. 4) In basal cell carcinoma, MTs were rather weakly expressed in solid cireumscribed types with a diffuse pattern and in cystic type with a patchy pattern. However they were not expressed in the solid infiltrative type. Conclusion : From these resuilts, we concluded that MTs were ubiquitously present in possible stem cells of various epithelial tissues except melanocytes irrespective of normal or artificial skin and/or mucosa including norrnal hair tissues. In the neoplasms of ectodermal origin, MTs might be involved in the invasive growth of tumor cells in the malignant melanoma and squamous cell carcinoma. It was implied that the role of MTs in basal cell carcinoma might be related to early events of hasal cell carcinogeresis and its down regulating tendency could be possible in its infil trative stage. (Kor J Dermatol 1997;35(1): 107-113)

모즈 미세도식 수술에 의한 기저세포암의 준임상적 침윤에 관한 연구

송기훈,김기호,조광열 ( Ki Hoon Song,Ki Ho Kim,Gwang Yeol Joh ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.5

Background: Mohs micrographic surgery is an ideal method for removing the BCC completely. Several studies defining proper lateral margin for excision of BCC have been reported. However, the study of invasion depth of BCC has not been specially addressed. Objective : In our study, we evaluated the safety lateral margin as well as depth of excision of BCC and the correlation with the histopathological aspects by using Mohs micrographic surgery technique. Methods : Fourty nine patients with BCCs(29 primary, 20 recurrent) diagnosed in the Department of Dermatology of Dong-A University Hospital from March, 1991 through February, 1997 were studied prospectively. Results: 1. Fifty five percent of tumors in our series had 2mm maxumal margins and 70% of recurrent BCC were eradicated with 4-mm more lateral margins. 2. Sixty two percent of BCC located in the cheek was eradicated with the excision within the mid-subcutaneous fat and more than 76% of the tumor in the nose required the removal of the periosteum or perichondrium. 3. In Ninety five percent of BCC, less than 14mm required a 4mm lateral margin and only 5% required a 6mm margin. However, seventy two percent of BCC was eradicated with a 4mm lateral margin and more than 36% was eradicated with a 6-mm or more lateral margin. 4. Eight percent of the micronodular type required 4mm or more lateral margins and had a tendency to invade more deeply. All nodular micronodular-infiltrative BCC had 4mm or more maximal subclinical extension and periosteum/perichondrial or deeper vertical invasion. Conclusion : Mohs micrographic surgery is an appropriate tool to use in proposing guidelines for treatment for BCC and clinicopathological characteristics of BCC such as anatomic location, tumor size, histopathological subtype may be helpful to plan the proper surgical margins. (Korean J Dermatol 1997;35(5): 915-923)