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개의 혈청과 장기조직 및 인공유발 심근경색견의 혈청 Creatine Phosphokinase(CPK) 총활성과 CPK Isoenzyme 분획
정한영,김덕환,Jeong Han-Young,Kim Duck-Hwan 한국임상수의학회 1992 한국임상수의학회지 Vol.9 No.2
Total CPK activities and CPK isoenzymes fractions of the sera and some organ tissues of dogs were examined to acquire the basic data of canine CPK available in clinical practice. In addition fluctuation of serum total CPK activities and CPK isoenzymes fractions is artificially induced canine myocardial infarctino were investigated to know the availabity of them as indicators for the diagnosis of myocardial infarction. For the determination of serum total CPK activities, total 22 clinically healthy dogs(7 to 30 months old, 15 of female and 7 of male) were used and 15 out of 22 dogs were used for the determination of serum CPK isoenzymes fractions. For the determination of total CPK activities and CPK isoenzymes fractions. some organ tissues (the hearts, skeletal muscles and brains )from 3 dogs were examined. For the fluctuation of total CPK activities and CPK isoenzymes fractions in the sera from artificially induced canine acute myocardial infarction, 3 dogs of coronary artery ligated experimental group and 3 of control group were used. The results obtained were as follows ; 1. Serum total CPK activities of normal dogs were 106.2${\pm}$29.9(31.3∼148.1)IU/$\ell$. 2. The pattern of serum CPK isoenzymes fractions in normal dogs was high with decreasing order of CK$_1$>CK$_3$>CK$_2$. 3. Total CPK activities of organ tissues were high with decreasing order of the skeletal muscles > the hearts > the brains. 4. The pattern of CPK isoenzymes fractions of the organ tissues was high with decreasing order of CK$_3$>CK$_2$ in the hearts and only CK$_3$(100%) was detected in the skeletal muscles. Further they were high with decreasing order of CK$_1$>CK$_3$>CK$_2$ in the trains. 5. Serum total CPK activities in experimental group were changed with higher values than those of control group. 6. In the fluctuation of serum CPK isoenzymes fractions the CK$_1$ CK$_2$ and CK$_3$ values were changed with higher values than those of control group. 7. It was become clear that the finding of Increase of serum total CPK activities, and CK$_2$ and CK$_3$ was important for the diagnosis of myocardial infarction.
김규용(Kim Gyu-Yong),구경모(Koo Kyung-Mo),이의배(Lee Eui-Bae),정한영(Jeong Han-Young),길배수(Khil Bae-Su),김무한(Kim Moo-Han) 대한건축학회 2009 大韓建築學會論文集 : 構造系 Vol.25 No.5
The performance of concrete mainly depend upon its water-cement ratio. If water percentage is excess in concrete, it may cause the degradation of performance. Because of these reasons, the change of water content is managed by using various evaluation method of unit water content. And criterion for the change of waer content is regulated and used. However the criterion is set only considering production error and measurement error but criterion does not consider performance degradation of concrete. Therefore this study tries to investigate degradation of performance while adding extra water by artificial manipulation or management error in concrete. The contents of extra water for tests are set as 0, 20, 40, 60㎏/㎥, to examine the performance degradation of concrete, strength, shrinkage, cracks, carbonation are tested. This study conclude that, when extra water content is excess than 20㎏/㎥ in concrete, then performance level of concrete declined rapidly. So it is very important to maintain quality of concrete for its better performance.
약물유해반응의 인과관계 판정을 위한 Naranjo와 WHO-UMC 지표의 비교
손명균 ( Myoung Kyun Son ),이용원 ( Yong Won Lee ),정한영 ( Han Young Jung ),이승우 ( Seung Woo Yi ),이광훈 ( Kwang Hoon Lee ),김승업 ( Seung Up Kim ),정재헌 ( Jae Heon Jeong ),박재준 ( Jae Jun Park ),박중원 ( Jung Won Park ),홍 대한내과학회 2008 대한내과학회지 Vol.74 No.2
목적: 약물유해반응의 인과관계를 분석함에 있어 그 객관성, 신뢰성 및 타당성을 증대시키기 위해 평가의 기준이 되는 지표들이 개발되어 왔다. 가장 널리 사용되는 평가지표인 Naranjo 지표와 WHO-UMC 지표를 비교 평가하였다. 방법: 세브란스 병원에 입원했던 환자 및 외래 추적관찰하는 환자들 중, 약물유해반응으로 보고된 환자들 100명을 후향적으로 분석하였다. 의무기록들을 검토하여 Naranjo와 WHO-UMC 지표를 적용, 평가하였다. 결과: Naranjo 지표와 WHO-UMC 지표의 평가를 비교 검토한 결과, 동일한 증례에 대해서 평가범주가 다르게 나타나는 경우가 많았다. WHO-UMC 지표와 비교할 때, Naranjo 지표로 평가한 결과는 상당히 관련이 있음(probable)으로 수렴되는 경향이 관찰되었다. Naranjo 지표는 위약투여에 대한 반응, 약물농도, 객관적인 검사, 이전 투약시의 반응, 약물용량조절에 대한 반응을 평가하는 항목들을 포함하고 있는데 실제로 임상에서 이런 검사 및 평가가 가능하거나 시행된 경우는 거의 없었다. 결론: Naranjo 지표는 어느 정도 타당성을 보여주고 있으나 한국의 임상 환경에서 WHO-UMC 지표에 비해 유용성이 제한적임을 알 수 있었다. Background/Aims: Several criteria have been proposed to increase the objectivity, reliability and validity of causality assessment of adverse drug reactions (ADR). We compared the Naranjo probability scale and the World Health Organization-Uppsala Monitoring Centre (WHO-UMC) causality categories to evaluate the validity and clinical usefulness of these criteria. Methods: We evaluated 100 ADR cases with the Naranjo probability scale and the WHO-UMC causality categories. The Spearman rank coefficient was used to determine the correlation of these criteria. The evaluation of the ADR was categorized into four groups for the Naranjo system: definite, probable, possible, and doubtful, and six groups for the WHO-UMC: certain, probable, possible, unlikely, conditional/unclassified, and unassessable. Results: The criteria used form these two systems showed some differences when compared with the same ADR cases. The Spearman rank coefficient was 0.519 (p<0.001) and the agreement was 55% between the Naranjo probability scale and the WHO-UMC causality categories. The Naranjo probability scale includes measurements for drug concentration, objective evidence of ADR, ADR to previous exposures, responses to placebo, and the dose adjustment of drugs. However, few cases were evaluated for all of these measures. Conclusions: The Naranjo probability scale may be helpful for assessing unexpected ADRs and useful for evaluators with little experience. However, some of the items are not utilized and there are discrepancies when compared with the WHO-UMC causality criteria.