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서진석 ( Jin Suk Suh ),황성욱 ( Sung Wook Hwang ),황권환 ( Kweon Hwan Hwang ),정기영 ( Gi Young Jeong ),정하현 ( Ha Hyun Joung ) 한국목재공학회 2012 목재공학 Vol.40 No.4
본 연구에서는 현재 국내 목조건축에서 벽구성 재료로 많이 사용되고 있는 수입 OSB(배향성 스트랜드보드)를 국산 합판으로 대체하기 위해 OSB와 국산 합판의 못 접합부 전단성능을 비교·검토하였다. 주부재(잣나무)와 측면부재(OSB·합판)의 섬유 방향성(평행·직각)에 따른 전단성능은 합판에서 현저하였다. 결과, OSB와 합판 모두 현행 국내 기준인 못 접합부 기준 허용전단내력을 만족하는 것으로 나타났다. 그리고, 표면층에 MLH(열대산 활잡목)를 사용하고 7ply 구성한 합판(P-4 type)은 OSB보다 섬유방향에 관계없이 큰 전단성능을 나타냈다. 전반적으로 측면부재로서 합판을 사용할 경우 주부재에 대하여 섬유방향을 직교되도록 구성할 경우,평행방향 구성보다 큰 전단성능을 발휘할 수 있음이 확인되었다. This study was carried out in order to compare nail shear strength between domestic plywood and imported OSB for structural sheathing members as infill wall of wooden construction. The differences of nail shear strength between parallel-to-grain direction and perpendicular-to-grain direction of sheathing material to frame material were distinct at the plywood composition. The shear strengths of plywood and OSB with nail met current design values. The plywood of P-4 type, which uses MLH at surface layer and constructs 7 ply, showed greater than OSB regardless of grain direction of sheathing material to frame material. When the plywood as sheathing material to frame material was used, it was found out that the overall construction of perpendicular-to-grain direction of plywood had greater nail shear strengths than the construction of parallel-to-grain.
Thioacetamide에 의한 BALB/c 마우스 간의 시간별 약물대사효소 억제 양상 : A Time-Course Study
이정운,고우석,김갑호,배연경,하현정,한상섭,천영진,정태천 영남대학교 약품개발연구소 2001 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-
Thioacetamide is a potent hepatotoxicant which requires metabolic activation by cytochrome P450s (P450s) for toxicity. In the present study, the elevation kinetic of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities by thioacetamide treatment was investigated in male BALB/c mice. Inaddition, the inhibitory effects of thioacetamide on liver microsomal P450 enzymes were further investigated. Thioacetamide at 100 mg/kg/ was treated intraperitoneally for 6, 12, 24, 36, 48 and 72 hr. The blood was collected at the designated time for assaying the serum enzyme activities. To determine the P450 isozyme-specific activities. ethoxyresorufin O-deethylase (EROD), methoxyresorufin O-demethylase (MROD), and benzyloxyresorufin O-debenzylase (BROD) activities were determined for P450 1A1, 1A2 and 2B1, respectively, in liver microsomal fractions. The activities of ALT and AST were started to be elevated 6 hr after thioacetamide treatment andreached the maximun at 36 hr after the treatment. The elevated activities were dramatically recovered at 72 hr. The microscopic exmination of the liver specimen also showed a similar profile of hepatotoxicity. All P450-associated enzyme activities were time-dependently inhibited by the treatiment with thioacetamide. The maximum inhibition of P450 enzymes was observed 36 hr after the treatment. Because the inhibition of P450 enzymes by thioacetamide was time-dependent, our present results suggest that thioacetamide might inhibit P450 enzymes in mechanism-based inactivation.