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한국에서의 후천성 면역 결핍증 환자에서 위장관을 침범한 카포시 육종의 증례발표 및 문헌고찰
정조윤 ( Cho Yun Chung ),박상우 ( Sang Woo Park ),명은 ( Eun Myung ),조동근 ( Dong Keun Cho ),송영아 ( Young A Song ),박강진 ( Kang Jin Park,),장희창 ( Hee Chang Jang ),주영은 ( Young Eun Joo ) 대한소화기학회 2012 대한소화기학회지 Vol.60 No.3
Kaposi sarcoma (KS) is a vascular neoplasm, which is fairly prevalent in acquired immunodeficiency syndrome (AIDS) patients. Mucocutaneous and lymph node involvements are characteristic features of KS in AIDS patients. The involvement of gastrointestinal tract occurs in 40% of KS patients and leads to significant morbidity and mortality. In the highly active antiretroviral therapy (HAART) era, the rate of AIDS related KS has fallen with control of human immunodeficiency virus (HIV) viremia. However, it is still recognized as the primary AIDS-defining illness, and the proportion of AIDS diagnoses made due to KS ranged from 4.1% to 7.5%. In Korea, AIDS-related KS has been report in low rate incidence. Its gastrointestinal involvements are rarely reported. To date, five cases have been recorded in Korea. Herein, we present an additional case of gastrointestinal KS as the AIDS-defining illness and review of the Korean medical literature. (Korean J Gastroenterol 2012;60:166-171)
최신 연구 소개 : 저 발효성 올리고당류, 이당류, 단당류, 폴리올 식이가 과민성장증후군의 증상을 완화시킬 수 있는가?
정조윤 ( Cho Yun Chung ),주영은 ( Young Eun Joo ) 대한소화기학회 2014 대한소화기학회지 Vol.64 No.2
과민성장증후군 환자들 중 많은 수에서 식후 증상 악화 및 특정 음식에 대한 역효과를 호소한다. 이러한 음식과민증(food intolerance)으로 인해 2/3의 환자에서 증상 개선을 위해 특정 음식물을 배제하고 섭취하고 있다. 최근에 발효성 oligosaccharides, disaccharides, monosaccharides와 polyols (FODMAPs)이 낮은 식이 조절이 임상에서 널리 각광 받고 있지만, 뒷받침할 수 있는 근거가 빈약한 상태이고 이러한 식단 조절은 자칫 부적절한 영양 섭취로 이르게 할 수 있다. 이에 Halmos 등1은 30명의 과민성장증후군 환자와 8명의 건강한 성인을 대상으로 전형적인 서구 식이와 FODMAPs이 낮은 식이요법 간의 무작위 대조연구를 진행하였고, 3주간의 식이 조절로 장 증상(복통, 복부 팽만감, 방귀)의 변화를 visual analogue scale (VAS)로 측정하였으며, 그 이외에 대변성상의 변화를 분석하였다. 또한 이들은 3주간의 휴약 기간 (washout period)을 거친 뒤에 다시 군을 바꾸어서 3주간의 식이요법을 진행하였다(Fig. 1). 그 결과 과민성장증후군 환자에서 저 FODMAPs 식이가 일반 서구 식이를 한 경우에 비해 유의하게 전반적인 장 증상이 완화되었고(low FODMAPs vs. typical diet, 22.8 vs. 44.9, p<0.001), 각각의 장 증상에 대한 VAS 역시 유의하게 호전된 결과를 보여주었다. 하지만 장증상 없는 건강한 성인의 경우, 식이 조절이 장 증상에 미치는 영향은 없었다. 또한 대변 성상의 변화를 분석할 때, 각 그룹간에 유의한 차이는 없었지만 저 FODMAPs 식이를 한 과민성장증후군 환자에서 대변에 대한 만족도가 더 높은 결과를 보여 주었다. 결론으로, 이번 임상 연구에서 과민성장증후군 환자를 대상으로 저 FODMAPs 식이를 하였을 때, 기능적인장 증상들이 감소한다는 결과를 보여주었으며, 저 FODMAPs 식이가 과민성장증후군 환자의 첫 번째 치료로 고려할 수 있는 근거를 확립하였다.
고감도 H<sub>2</sub>S 감지를 위한 SnO<sub>2</sub> 장식된 Cr<sub>2</sub>O<sub>3</sub> nanorods 이종구조
정재한 ( Jae Han Chung ),조윤행 ( Yun-haeng Cho ),황준호 ( Junho Hwang ),이수형 ( Su Hyeong Lee ),이승기 ( Seunggi Lee ),박시형 ( See-hyung Park ),손성우 ( Sungwoo Sohn ),조동휘 ( Donghwi Cho ),이광재 ( Kwangjae Lee ),심영석 ( You 한국센서학회 2024 센서학회지 Vol.33 No.1
The creation of vertically aligned one-dimensional (1D) nanostructures through the decoration of n-type tin oxide (SnO<sub>2</sub>) on p-type chromium oxide (Cr<sub>2</sub>O<sub>3</sub>) constitutes an effective strategy for enhancing gas sensing performance. These heterostructures are deposited in multiple stages using a glancing angle deposition technique with an electron beam evaporator, resulting in a reduction in the surface porosity of the nanorods as SnO<sub>2</sub> is incorporated. In comparison to Cr<sub>2</sub>O<sub>3</sub> films, the bare Cr<sub>2</sub>O<sub>3</sub> nanorods exhibits a response 3.3 times greater to 50 ppm H<sub>2</sub>S at 300°C, while the SnO<sub>2</sub>-decorated Cr<sub>2</sub>O<sub>3</sub> nanorods demonstrate an eleven-fold increase in response. Furthermore, when subjected to various gases (CH<sub>4</sub>, H<sub>2</sub>S, CO<sub>2</sub>, H<sub>2</sub>), a notable selectivity toward H<sub>2</sub>S is observed. This study paves the way for the development of p-type semiconductor sensors with heightened selectivity and sensitivity towards H<sub>2</sub>S, thus advancing the prospects of gas sensor technology.
경사각 증착법 이용한 1차원 나노구조체 기반의 가스센서에 관한 연구 동향
이승기(Seunggi Lee),정재한(Jae Han Chung),조윤행(Yun Haeng Cho),조동휘(Donghwi Cho),심영석(Young-Seok Shim) 한국세라믹학회 2023 세라미스트 Vol.26 No.3
One-dimensional (1D) nanostructures allow for precise control of geometrical size and shape, offering greater design flexibility than other nanostructures. 1D nanostructures, in particular, hold immense potential for revolutionizing the gas sensor field, owing to their extensive surface areas conducive to chemical reactions. To harness this potential, researchers have dedicated their efforts to developing fabrication methods that incorporate 1D nanostructures into gas sensor applications. Various techniques have been explored, including hydrothermal synthesis, electrospinning, sol-gel processes, solid-state chemical reactions, vapor-phase transport, and chemical vapor deposition. Despite these advancements, challenges regarding uniformity and reproducibility persist. In this report, we review the glancing angle deposition (GLAD) technique for applying 1D nanostructures to gas sensors and discuss to the potential of GLAD in overcoming existing limitations and driving forward the realm of 1D nanostructure-based gas sensors.
간세포암 환자에서 경동맥화학색전술 후 종양혈전의 이동에 의해 합병된 급성 폐쇄성 담관염: 증례보고 및 문헌고찰
박형철 ( Hyung Chul Park ),박현범 ( Hyun Bum Park ),정조윤 ( Cho Yun Chung ),정민우 ( Min Woo Jung ),주영은 ( Young Eun Joo ),최성규 ( Sung Kyu Choi ),조성범 ( Sung Bum Cho ) 대한소화기학회 2014 대한소화기학회지 Vol.63 No.3
Intraductal tumor invasion of hepatocellular carcinoma (HCC) is considered rare. Transarterial chemoembolization (TACE) is effective for tumor thrombus of HCC in the bile duct. However, a few cases of obstructive jaundice caused by migration of a tumor fragment after TACE have recently been reported. The aim of this study was to identify factors that affect tumor migration after TACE. At this writing, a review of the medical literature disclosed seven reported cases of biliary obstruction caused by migration of a necrotic tumor cast after TACE. We, herein, report on an additional case of acute obstructive cholangitis complicated by migration of a necrotic tumor cast after TACE for intrabile duct invasion of HCC, in a 71-year-old man. The tumor cast in the common bile duct was removed successfully using a basket during ERCP and was pathologically confirmed to be a completely necrotic fragment of HCC. The patient`s symptoms showed dramatic improvement. In summary, physicians should be aware of acute obstructive cholangitis complicated by tumor migration in a patient undergoing TACE. We suggest that an intrabile duct invasion would be a major predisposing factor of tumor migration after TACE and drainage procedures such as ERCP or percutaneous transbiliary drainage could be effective treatment modalities in these patients.
위장관 ; 위장관기질종양과 구별되는 위 신경초종의 초음파 내시경 특징
박형철 ( Hyung Chul Park ),손동준 ( Dong Jun Son ),오형훈 ( Hyung Hoon Oh ),옥찬영 ( Chan Young Oak ),김미영 ( Mi Young Kim ),정조윤 ( Cho Yun Chung ),명대성 ( Dae Seong Myung,),김종선 ( Jong Sun Kim ),조성범 ( Sung Bum Cho ),이 대한소화기학회 2015 대한소화기학회지 Vol.65 No.1
Background/Aims: Gastric schwannoma (GS), a rare neurogenic mesenchymal tumor, is usually benign, slow-growing, and asymptomatic. However, GS is often misdiagnosed as gastrointestinal stromal tumors (GIST) on endoscopic and radiological examinations. The purpose of this study was to evaluate EUS characteristics of GS distinguished from GIST. Methods: A total of 119 gastric subepithelial lesions, including 31 GSs and 88 GISTs, who were histologically identified and underwent EUS, were enrolled in this study. We evaluated the EUS characteristics, including location, size, gross morphology, mucosal lesion, layer of origin, border, echogenic pattern, marginal halo, and presence of an internal echoic lesion by retrospective review of the medical records. Results: GS patients comprised nine males and 22 females, indicating female predominance. In the gross morphology according to Yamada`s classification, type I was predominant in GS and type III was predominant in GIST. In location, GSs were predominantly located in the gastric body and GISTs were predominantly located in the cardia or fundus. The frequency of 4th layer origin and isoechogenicity as compared to the echogenicity of proper muscle layer was significantly more common in GS than GIST. Although not statistically significant, marginal halo was more frequent in GS than GIST. The presence of an internal echoic lesion was significantly more common in GIST than GS. Conclusions: The EUS characteristics, including tumor location, gross morphology, layer of origin, echogenicity in comparison with the normal muscle layer, and presence of an internal echoic lesion may be useful in distinguishing between GS and GIST.