경관임신의 1례

정재훈(JH Chung),하근수(KS Ha),박두철(DC Park),하옥근(OK Ha),배국환(KH Bae) 대한산부인과학회 1970 Obstetrics & Gynecology Science Vol.13 No.10

A case of cervical pregnancy recently admitted to Pusan Maryknoll Hospital was presented and a brief review of the literature on cervical pregnancy was made.

수종약제가 태반조직호흡에 미치는 영향

정재훈(JH Chung),김동성(DS Kim),김규진(KJ Kim),권병일(BI Kwon) 대한산부인과학회 1964 Obstetrics & Gynecology Science Vol.7 No.2

1. 임신각기에 있어서의 정상인체태반의 조직호흡을 Warburg 표준검압법에 의하여 측정하였다. 2. 임신 6주에서는 QO2가 2.80, 14주에서 2.44, 16주에서 2.15, 20주에서 2.01, 28주에서 1.29, 40주에서는 1.21로서 임신주수가 진행함에 따라 대체적으로 점차 감소됨을 보았다. 3. Pitocin을 첨가한 태반의 산소소모능은 임신각기에서 비첨가군보다 약간 항진되는 경향을 보여 주고 있었다. 4. Methotrexate를 첨가한 태반의 산소소모능은 임신각기에서 약간 감소됨을 알 수 있다. 5. Endoxan, nitromin 첨가군에서도 전반적으로 조직의 산소소모능이 억제되는 경향을 보여 주었고 임신 40주태반에 있어서는 그 산소소모능을 약 50%로 감소시키는 것 같은 양상을 볼 수 있었다. Very few human tissuse other than the placental tissue are readily available for in vitro studies. Despite this fact, little is known about the influence of metabolites or pharma cological agents upon this tissue. Any knowledge that may be obtained about the behavior of this complex organ, further-more, may assist in understanding some unsolved problems of human reproduction. Experimental drugs used are pitocin, Methotrexat. Endoxan (Cyclophosphamide) and Nitromin. The tissuse were obtained in various gestational ages and normal term placenta. The rate of oxygen consumption of fresh human placental tissue was measured by Warburgs standard manometric technique. The result obtained are summarized as follows: 1) Progressive decline in oxygen uptake with advancing pregancy from QO 2.80μ 102/mg dry weight/hour at 6 weeks gestation. 2.44 at 14 weeks. 2.15 at 16 weeks, 2.01 at 20 weeks, 1.29 at 28 weeks and 1.21 at term. 2) The QO2 of human placenta in various gestation is stimulated by pitocin. 3) The QO2 of human placental tissue is depressed by Methotrexate. 4) The QO2 of human placental tissue is depressed by Endoxan (Cyclophosphamide) and Nitromin. These drugs exerted depression of exygen uptake at term placenta significantly.

폐 , 뇌 , 간 , 신 및 골에 전이된 융모상피암의 1 례

백영배(YB Beik),정기묵(KM Chung),정재훈(JH Chung) 대한산부인과학회 1986 Obstetrics & Gynecology Science Vol.29 No.5

골에 전이된 전이성 융모상피암은 매우 희귀한 질환으노 저자들은 최근에 폐, 간, 신장, 뇌 및 경골의 필상돌기 주위에 전이된 융모상피암을 Methotrexate, Actinomycin-D Cytoxan의 병합 화학요법과 CHAMOCA regimen, 척수강내 MEthotrexate 및 뇌방사선 조사를 실시하였으나 치료도중 뇌출혈로 사망한 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Metastasis of choriocarcinoma to the distal end of tibia is a rare condition. We had an experience of multiple metastatic choriocarcinoma in lung, liver, kidney, brain and the distal end of tibia. The patient was treated with combined chemotherapy, intrathecal MTX and irradiation of the brain. She was eventually died of intracranial hemorrhage although generalized symptoms were gradually improved. Here, we report a case of metastatic choriocarcinoma at the distal end of tibia with a brief review of the concerned literatures.

쌍각자궁을 동반한 선천적 질결여의 1예

김규진(KJ Kim),이병채(BC Lee),정재훈(JH Chung),김동성(DS Kim) 대한산부인과학회 1964 Obstetrics & Gynecology Science Vol.7 No.3

여성 생식기의 선천적 결여의 정도는 심한 것은 완전히 없어지는 것으로부터 경한 것은 일부만 없어지는 것 등 여러가지이나 임상적으로 가장 흔히 볼 수 있는 것은 질의 전부 혹은 일부 결여하는 것이다. 금반 본교실에서 쌍각자궁에 수반하여 질 하 2/3의 선천적 결여를 가진 환자를 치험 하였기에 보고하는 바이다. A case of congenital absence of vagina with bicornuate uterus is reported. And a brief review on the literature is made.

진행된 부인과적 악성종양에 대한 cis-Platinum과 Adriamycin 병합요법의 반응과 독성에 관한 임상적 고찰

김원규(WK Kim),정기묵(KM Chung),정재훈(JH Chung) 대한산부인과학회 1986 Obstetrics & Gynecology Science Vol.29 No.3

1982년 1월부터 1984년 6월말 사이에 고신의대 산부인과에 입원핸 재발성 또는 지속성 자궁경부암 환자 18예, stage Ⅱ 이상의 난소상피암 환자 7예, 그리고 원발성불명 전이성 선암 환자 3예등 총 28예를 대상으로 cis-Platinum 50mg/m2과 Adriamycin 50mg/m2을 2~4주 간격으로 1회 1시간내 혈관내 주입법으로 투약하여 다음과 같은 결론을 얻었다. 1. 약제에 대한 반응을 관찰할 수 있었던 환자는 3회 이상 투약한 경우로 총 14예 였으며 이들은 각각 자궁경부암 7예, 난소상피암 5예, 원발성불명 전이성 선암 2예였다. 2. 전체적 반응도는 총 14예 중 7예로 50%였다. 3. 자궁경부암은 7예 중 3예에서 부분적관해(42.6%)를 보였으며 2예는 약간의 호전만 있었고 나머지 2예는 변화를 보이지 않았으나 투약기간 동안 더 이상 진행되지는 않았다. 4. 난소상피암 환자는 5예 중 2예에서 완전관해, 1예는 부분적관해를 보여 60%의 반응도를 보였고 나머지 2예는 약간의 호전과 무변화로 각각 1예씩이었다. 5. 원발성불명 전이성 선암 환자 2예는 부분적관해와 무변화 각각 1예로 50%의 반응도를 보였다. 6. 자궁경부암, 난소상피암 및 원발성불명 전이성 선암의 모든 예에서 cis-Platinum과 Adriamycin을 투약중에는 더 진행된 예는 없었다. 7. 약제의 독성으로는 골수에 대한 독성은 28예 중 8예로 29%, 신장독성은 28예중 8예로 29%, 심장독성은 28예중 7예로 21%, 위장관독성은 28예중 28예로 100%에서 나타났다. 위의 모든 독성은 환자가 견딜 수 있을 정도였으며 투약후 2주내에 모두 정상으로 회복되었다. Twenty-eight patients with advanced gynecologic malignant neoplasms who had prior surgery and/or radiation and no longer amenable with surgery and/or radiation were treated with combination chemotherapy of cis-Platinum 50mg/m2 and Adriamycin 50mg/m2 from January, 1982 to June, 1983 at the Department of Obstetrics & Gynecology, Kosin Medical College. 1) We evaluated all the 28 patients for toxicity. To evaluate response, we selected 14 patients who were treated at least three courses of chemotherapy, included 7 patients of cervical cancer, 5 patients of ovarian epithelial cancer, 2 patients of metastatic adenocarcinoma of ovary. 2) The over-all response rate 50 percent(7/14). 3) The responses in cervical cancers were 3 partial responses, 2 improvements and 2 stable diseases in 7 patients. The response rate were 42.6 percent(3/7). 4) The responses in ovarian epithelial cancers were 2 complete responses, 1 partial response and 2 improvements in 5 patients. The response rate were 60 percent(3/5). 5) The responses in metastatic adenocarcinoma of ovary were 1 partial response and 1 stable disease in 2 patients. The response rate were 50 percent(1/2). 6) There were no progressive disease in all patients during combination chemotherapy of cis-Platinum-Adriamycin. 7) Toxicity included myelosuppression(29%), nephrotoxicity(29%), ototoxicity(21%), gastrointestinal toxicity(100%), cardiac toxicity(29%) and alopecia(100%). These toxicities were generally mild to moderate and appeared tolerable.

자궁경부에 발생한 자궁내막증 1예

신윤식(YS Shin),박재인(JI Park),정백수(BS Chung),유길조(KJ Rheu),정재훈(JH Chung) 대한산부인과학회 1982 Obstetrics & Gynecology Science Vol.25 No.10

자궁경부에 발생하는 자궁내막증은 그 주된 직접적인 원인이 외상에 의해서 생기는 일이 많다고 주장하고 있다. 근래 자궁경부생검, 전기소작, 자궁경부원추절제술 등의 외과적 처치가 종전보다 증가되는 경향이 있으므로 앞으로는 자궁경부자궁내막증은 그 빈도가 더 많아질 것으로 추측된다. 저자들은 최근 본부속병원 산부인과 병실에 입원 수술한 환자중에 자궁경부자궁내막증의 1예를 관찰할 수 있었기에 간단한 문헌고찰과 함께 그 증례를 보고하는 바이다. Incidence of the cervical endometriosis is rare among the pelvic endometriosis, Recently we experienced a case of the cervical endometriosis that we present a brief review of literature.

진행된 원발성 자궁경부암에 대한 Adriamycin, Bleomycin, Cisplatinum 병합요법의 반응에 관한 임상적 고찰

전이양(LY Jun),한공창(GC Han),박은동(ED Park),정재훈(JH Chung) 대한산부인과학회 1989 Obstetrics & Gynecology Science Vol.32 No.1

This study was carried out based on the clinical record of 15 patients in primary advanced cervical cancer who were treated with combination chemotherapy with Adrimatycin 50 mg/m^2, Bleomycin 20mg and Cisplatinum 50 mg/m^2 at the Department of Obsterics and Gyunecology , Kosin medical College Hospital during the period from Oct. 1, 1985 to July 31. 1986. The results were obatained as follows. 1. Overall objective tumor response showed 53.3%(8/15) complete response were 6.7%(1/15) and partial responses were 46.7%(7/15). 2. According to the stage, response rate of cancer of cervix were as follows, stage IIb showed 72.7%(8/11) one patients of stage IIIa and 3 patients of IIIb showed only stable disease. 3. The response group showed its effectiveness from the first or 2nd course of combination chemotherapy. 4. In most of the unresponse group (7patients ) it was observed that size of tumor mass was not increased but rather it was decreased in size.

무심장 무두 내장탈출증을 동반한 기형아의 1례

김대봉(DB Kim),이문희(MH Lee),한공창(GC Han),유길조(KJ Rheu),정재훈(JH Chung) 대한산부인과학회 1984 Obstetrics & Gynecology Science Vol.27 No.10

A case of Holocardiac Acephalic Monster associated with single ovum twin combined with omphalocele was presented. This monster was delivered by partial breech extraction, its weight was about 1600gm. And review of literature was made briefly.

Krukenberg 종양의 4예

강대경(DK Kang),김성환(SW Kim),김인식(IS Kim),정재훈(JH Chung) 대한산부인과학회 1973 Obstetrics & Gynecology Science Vol.16 No.7

We have experienced 4 cases of Krukenberg`s tumor of ovary during 5 years survey from Jan. 1967 to Jan. 1971. in Maryknoll Hospital. Krukenberg`s tumor are generally believed that it is almost metastatic tumor from G.I. tract or breast, but Novak have pointed that about 20 percent seem primary in nature. In our cases, 3 cases have distinct origin and one can`t find accurate original site. And here we represent case presentation and review of literature was made briefly.

진행된 원발성 및 지속성 재발성 자궁경부암에 Adriamucin, Bleomycin, Cisplatinum 병합요법 의 반응에 관한 임상적 고찰

전이양(LY Jun),김원기(WK Kim),정기목(KM Chung),정재훈(JH Chung) 대한산부인과학회 1988 Obstetrics & Gynecology Science Vol.31 No.5

본 고신의대 산부인과학교실에서 진행된 원발성 및 ㅈ속성, 재발성 자궁경부암의 치료로서 ADR-BLM-DDP병합화학요법을 시행하여 그 반응 및 독성을 관찰하였다. 1. 종양관해율은 34.8% (8/23)로 나타났으며 이중 완전관해 8.7%(2/23) 부분관해 26.1%(6/23) 였다. 2. 진행된 원발성, 지속성 및 재발성 자궁경부암에서 각각의 관해율은 45.5%, 25%를 보였다. 3. 종양관해기간은 4개월에서 17개월로 평균 7.6개월이엇다. 4. 약제에 대한 독성은 골수독성이 43.5%, 신장독성 26%, 간장독성 17.4%, 청각독성 17.4%, 심장독성 13% 및 위장관독성이 100%로 나타났다. 5. 대부분의 환자에서 약물독성에 대해 잘 견디었으며 사망한예는 없었고, 독성이 관찰된 경 우는 대증요법으로 호전되었다. This study was carried out based on the clinical records of 23 patients in primary advanced persistent and recurrent cervical cancer who were treated with combination chemotherapy with Adriamycin 40mg/m^2, Bleomycin 20mg and Cisplatium 50mg/m^2 at the Department of Obsterics and Gyunecology , Kosin medical College Hospital during the period from May 1. 1984 to Feb. 28, 1986 The results were obtained as follow. 1. Total 8 of 23 patients (34.8%) showed objective tumor response and complete responses were seen in 2 patients (8.7%) and partial responses were in 6 patients (26.1%). 2. The tumor response showed in primary advanced , persistent and recurrent cervical cancer 45.5%, 25% and 25% respectively. 3. The response duration were from 4 months to 17 months mean duration were 7.6 months. 4. Toxiciety included myelosuppression (43.5%) nephrotoxicity (26%) hepatotoxity(17.4%) ototoxicity (17.4%) cardiac toxicity (13%) gastro-intestinal toxicity (100%). 5. Majority of patients were well tolerable and no death the toxicity observed was diminished on conservative treatment .