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RISS 인기검색어
- 검색키워드
- 저자 : 전이양(LY Jun) (검색결과 2 건)
- 무료
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진행된 원발성 자궁경부암에 대한 Adriamycin, Bleomycin, Cisplatinum 병합요법의 반응에 관한 임상적 고찰
전이양(LY Jun),한공창(GC Han),박은동(ED Park),정재훈(JH Chung) 대한산부인과학회 1989 Obstetrics & Gynecology Science Vol.32 No.1
This study was carried out based on the clinical record of 15 patients in primary advanced cervical cancer who were treated with combination chemotherapy with Adrimatycin 50 mg/m^2, Bleomycin 20mg and Cisplatinum 50 mg/m^2 at the Department of Obsterics and Gyunecology , Kosin medical College Hospital during the period from Oct. 1, 1985 to July 31. 1986. The results were obatained as follows. 1. Overall objective tumor response showed 53.3%(8/15) complete response were 6.7%(1/15) and partial responses were 46.7%(7/15). 2. According to the stage, response rate of cancer of cervix were as follows, stage IIb showed 72.7%(8/11) one patients of stage IIIa and 3 patients of IIIb showed only stable disease. 3. The response group showed its effectiveness from the first or 2nd course of combination chemotherapy. 4. In most of the unresponse group (7patients ) it was observed that size of tumor mass was not increased but rather it was decreased in size.
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진행된 원발성 및 지속성 재발성 자궁경부암에 Adriamucin, Bleomycin, Cisplatinum 병합요법 의 반응에 관한 임상적 고찰
전이양(LY Jun),김원기(WK Kim),정기목(KM Chung),정재훈(JH Chung) 대한산부인과학회 1988 Obstetrics & Gynecology Science Vol.31 No.5
본 고신의대 산부인과학교실에서 진행된 원발성 및 ㅈ속성, 재발성 자궁경부암의 치료로서 ADR-BLM-DDP병합화학요법을 시행하여 그 반응 및 독성을 관찰하였다. 1. 종양관해율은 34.8% (8/23)로 나타났으며 이중 완전관해 8.7%(2/23) 부분관해 26.1%(6/23) 였다. 2. 진행된 원발성, 지속성 및 재발성 자궁경부암에서 각각의 관해율은 45.5%, 25%를 보였다. 3. 종양관해기간은 4개월에서 17개월로 평균 7.6개월이엇다. 4. 약제에 대한 독성은 골수독성이 43.5%, 신장독성 26%, 간장독성 17.4%, 청각독성 17.4%, 심장독성 13% 및 위장관독성이 100%로 나타났다. 5. 대부분의 환자에서 약물독성에 대해 잘 견디었으며 사망한예는 없었고, 독성이 관찰된 경 우는 대증요법으로 호전되었다. This study was carried out based on the clinical records of 23 patients in primary advanced persistent and recurrent cervical cancer who were treated with combination chemotherapy with Adriamycin 40mg/m^2, Bleomycin 20mg and Cisplatium 50mg/m^2 at the Department of Obsterics and Gyunecology , Kosin medical College Hospital during the period from May 1. 1984 to Feb. 28, 1986 The results were obtained as follow. 1. Total 8 of 23 patients (34.8%) showed objective tumor response and complete responses were seen in 2 patients (8.7%) and partial responses were in 6 patients (26.1%). 2. The tumor response showed in primary advanced , persistent and recurrent cervical cancer 45.5%, 25% and 25% respectively. 3. The response duration were from 4 months to 17 months mean duration were 7.6 months. 4. Toxiciety included myelosuppression (43.5%) nephrotoxicity (26%) hepatotoxity(17.4%) ototoxicity (17.4%) cardiac toxicity (13%) gastro-intestinal toxicity (100%). 5. Majority of patients were well tolerable and no death the toxicity observed was diminished on conservative treatment .
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