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건강한 한국인 자원자에서 테가세로드(Tegaserod) 반복 투여에 의한 안전성 및 약동학 평가
정재용,임형석,홍경섭,배균섭,유경상,조주연,이소영,고재욱,장인진,신상구,Chung, Jae-Yong,Lim, Hyeong-Seok,Hong, Kyoung-Sup,Bae, Kyun-Seop,Yu, Kyung-Sang,Cho, Joo-Youn,Yi, So-Young,Ko, Jae-Wook,Jang, In-Jin,Shin, Sang-Goo 대한임상약리학회 2003 Translational and Clinical Pharmacology Vol.11 No.2
Background: Tegaserod is a selective partial agonist at the $5HT_4$ receptor. Tegaserod belongs to a new class of agents in development for the treatment of functional motility disorders of the gastrointestinal(GD tract. This Phase I clinical study was conducted to evaluate the safety and pharmacokinetics(PK) of tegaserod in Korean for bridging foreign clinical data. Methods: A randomized, double blind, placebo controlled, multiple oral dosing(2 mg, 6 mg, twice a day for 7 days) study was conducted in 32 healthy Korean volunteers(M:F=16:16). Serial blood samples for pharmacokinetic analysis were taken. Safety evaluation was performed by adverse event monitoring, physical examination including vital signs, ECG and clinical labororatory analysis. Results: Plasma concentration of tegaserod reached peak levels $1.0{\sim}1.5$ hours after single and multiple dose administration and declined with a terminal half life of about 12 hours. PK parameters of 2 mg group were not calculated well due to low plasma concentration. Tegaserod showed linear pharmacokinetic characteristics, and little accumulation occurred after multiple administrations. There were no gender differences in PK parameters. Neither serious nor dose-limiting adverse events were observed. PK of tegaserod in Koreans was comparable to Caucasian data. Conclusion: Tegaserod was found to be safe and showed similar PK characteristics to Caucasians. This study demonstrates comparability between Korean and Caucasian healthy subjects in the PK of tegaserod and supports the use of Caucasian data in the evaluation of PK, safety, and efficacy for Korean patients.
건강 자원자에서 레베셀$^{\circledR}$주(DDB-S)의 안정성, 약동학적 특성평가를 위한 제 1상 임상시험
정재용,임형석,배균섭,유경상,홍경섭,조주연,이소영,문전옥,이치오,장인진,신상구,Chung, Jae-Yong,Lim, Hyeong-Seok,Bae, Kyun-Seop,Yu, Kyung-Sang,Hong, Kyoung-Sup,Cho, Joo-Youn,Yi, So-Young,Moon, Jun-Ok,Lee, Chi-Oh,Jang, In-Jin,Shin, Sang- 대한임상약리학회 2001 臨床藥理學會誌 Vol.9 No.2
Background : Low solubility and poor oral absorption have been major problems of DDB(Dimethyl Dime-thoxy Biphenylate), the liver protection agent. The purpose of the study was to evaluate safety, tolerablilty, and pharmacokinetics of DDB-S(Dimethoxybiphenylmonocarboxylate hydro-chloride) which was the newly developed soluble injectable form of DDB. Method : Single dose trial was conducted in 24 healthy Korean subjects with single blind, randomized, placebo controlled parallel-group design( 4 groups : 7.5, 15, 30, 60mg). DDB-S was administrated by intravenous infusion during 60 minutes. Serial blood and urine sample were collected till 24 hours after the drug administration. Plasma concentrations were assayed by HPLC. Pharmacokinetic parameters were analyzed by noncompartmental methods. Results : Total 13 cases of adverse events from 7 subjects were reported. All the events were mild, temporary, and spontaneously resolved. There were no differences in dose normalized AUC, dose normalized Cmax, CL, Vd, Tmax, Fe, $CL_R$ and elimination rate constant between groups. Linear regression analysis confirmed PK linearity within this dose range. Half of the dose$(49.86{\pm}10.97%)$ was excreted as an unchanged form through kidney. Conclusion : DDB-S was safe in Korean healthy subjects. It showed linear pharmacokinetic characteristics. Phase II clinical study for patients will be conducted.
정재용(Chung, Jae-Yong),박훈(Park, Hoon) 대한건축학회 2018 대한건축학회논문집 Vol.34 No.1
UNESCO has continued to work in Africa, especially in the six southern sub-Saharan countries, and Asia, where international cooperation is needed. The CLC (Rwanda Community Learning Center) covered in this study aims to create a regional learning center in Rwanda and to recover local communities and provide learning environment. During the course of this study, we conducted field trips for actual planning and reviewed the current state of educational and cultural facilities that recently opened and are operated, and found implications. In consultation with the Rwandan Educational Commission, the site for CLC was decided, the building was designed, and the construction is about to start. The results of this study are as follows. First, in addition to the efforts of the activists in the village, which can be considered the smallest unit of a local community, the approach for establishing an architectural space and active education and community environment can be evaluated as a result of experimental efforts. Second, we can pay attention to the attempts to realize local communities. The bridge business is based on the multi-purposes such as early childhood education, technical education for adults, and community restoration of local residents and it reflects space and program plans for this purposes. It also reflects detailed plans such as differentiating the flow planning depending on users’ time of use. Third, we can explain the characteristics of architectural planning considering local characteristics such as active use of local materials. Due to the characteristics of a developing country, there were significant considerations on maintenance, and to this end, the plan included plans for the environment and use of materials that are easily maintained. In addition, the participation of local residents in the process of establishment was suggested as a possibility to serve an educational role.
정재용(Chung Jae-Yong),박훈(Park Hun) 대한건축학회 2008 대한건축학회논문집 Vol.24 No.2
Urban development was spearheaded by modern architecture, which caused many problems since the late 20th century. Environmental issues, in particular, have emerged as one of the most serious problems. So this study is an interdisciplinary research that aims to seek the interrelationship between environmental discourses, typology of environment-friendly architecture and urban space. This study undertook a broad range of case studies including office buildings, residential-commercial mixed use buildings and housing in Britain, Germany, Japan, Australia and South Korea in order to analyse a broad range of environmwntally friendly architecture. These case studies were first analysed in terms of three main environmental theoretical approaches such as technocentrism, ecocentrism and anthropocentrism (or eco-socialism as it is better known). This result was mapped on the urban hierarchy, technocentric typological buildings mainly being office buildings were located in or near the city centre. Anthropocentric type buildings that eccentuates the need for community and social sustainability were found in the general urban to suburban urban areas In the meanwhile, cases of biocentrism largely featured in the outskirts of cities and countryside as they need more land for self-sufficiency for food and treating waste organically with emphasis on small commune type developments. Environmental discourses such as technocentrism, biocentrism and anthropocentrism, which proposes different visions of future settlements should not be regarded as opposing political solutions but should be used as different spatial strategies. This study suggests that three approaches are all relevant environmental strategies in different locations, ie each approach are spatial strategies in different urban hierarchy. The technocentrism and its architectural types are ecological solution for urban core, whereas anthropocentrist approach a solution for social sustainability in general residential areas in urban and suburban locations and biocentrist solution being appropriate for the rural areas. The necessity of economic sustainability of cities dictate the differentiated locational factors of ecological techniques as well as density of developments. And, therefore, appropriate adoption of differentiated types of ecological approaches and related buildings in accordance with the hierarchy of urban spaces are needed in order to address the sustainability of human environment.
정재용(Chung Jae-Yong),이승창(Lee Seung-Chang),오정근(Oh Jung-Keun) 대한건축학회 2007 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.27 No.1
Recent advancement of CFD (Computational Fluid Dynamics) technique makes it possible to predict the wind flows around a building and a structure under the wind-induced conditions very close to the actual state. Therefore the practical use of CFD even for wind-resistant design becomes almost realized now. Due to the trend of applicability of CFD, the computed wind-induced pressure distribution on hemispherical domes is estimated. Pressure coefficients, referenced to freestream static pressure, were investigated for domes with height to diameter ratios of 1, 1/2, and 1/3. The results of numerical simulation were compared with tthe experimental data. Based on the results of the numerical simulation obtained in a good agreement with the experimental data. The numerical simulations are used to predict the pressure coefficients on the surfaces of the structure and to evaluate the wind environment. This paper suggests the applicability of the numerical simulation in the field of wind engineering.