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Ranitidine 의 소화성궤양치료효과에 대한 임상적연구
김영건(Young Kun Kim),윤성열(Sung Yeul Yoon),정현용(Hyeon Yong Jeong),정선묵(Seon Muk Jeong) 대한소화기학회 1983 대한소화기학회지 Vol.15 No.2
N/A This study was performed to assess the clinical therapeutic effectiveness of anti-histamine agent, ranitidine. The drug was given in the dose of 150mg twice a day to 12 cases of gastric ulcer and 11 cases of duodenal ulcer. Initial diagnosis and follow up observation after 4 weeks, 6 weeks and 8 weeks of treatment were made by the upper G-I endoscopy. The results observed are as followings. 1) The male to female ratio of the subject was about 20:3 and the most prevalent age group was the sixth decade of the life in both the gastric and duodenal ulcer groups. 2) The location of gastric ulcer were 7 cases in body and 5 cases in angle of the stomach and duodenal ulcer were 7 cases in bulb and 4 cases in pyloric area. 3) As for the subjective symptoms, epigastric pain, heart-burning sensation, hunger pain, abdominal discomfort, dyspepsia were experienced, and were relieved after 1 week of treatment in 60 80%, and were completely relieved after 4 weeks of treatment in all cases respecti vely. 4) The cumulative rates of complete healing of the gastric ulcer (12 cases) were 75% (9 cases) after 4 week, 92% (11 cases) after 6weeks, 100%(12 cases) after 8 weeks of treatment, and those of the duodenal ulcer (11 cases) were 91%(10 cases) after 4 weeks, 100%(11 cases) after 6 weeks of treatment. 5) The untoward side effect were not found. In conclusion ranitidine appears to be effective and safe for the treatment of patients with peptic ulcer disease.
김영건(Young Kun Kim),이복희(Bok Hee Lee),정선묵(Seon Muk Jeong),정현용(Hyun Yong Jeong),김연길(Yun Keel Kim) 대한소화기학회 1984 대한소화기학회지 Vol.16 No.2
N/A A clinical analysis was performed in 408 patients with peptic ulcer among the various upper gastrointestinal diseases(2108 cases), who were diagnosed gastroduodenoscope at the endoscopic room of Chung Nam National University Hospital during period from January 1980 to August 1984. The results were as',follows: I) Of the total 2108 cases, the main diseases were gastritis(28.5%), gastric cancer(195 benign gastric ulcer(11.5%), etc, in order of frequency. 2) The symptoms of peptic ulcer were epigastric pain or discomfort(83.5%), melena or hematemesis(39.4%), indigestion, etc. 3) Of the 408 cases with peptic ulcer, 239 cases(58%) were gastric ulcer, 144 cases(35%) were duodenal ulcer and others were gastroduodenal combined ulcer. 4) Of the 408 cases with peptic ulcer, 339 cases (83.1%) were male and 68 cases(16.9%) were female. The male to female ratio was 5:1 and the highest number was in the 3th decade (26.2%). Gastric ulcer was distributed most commonly in the 6th decade(32.6%) and had high male to female ratio(6:1). Duodenal ulcer was been relatively younger age of the 4th decade(25%) and 5th decade(24%), had low male to female ratio(3.5:1). 5) In the annual distr ibution of peptic ulcer from to 1984, gastric ulcer was 29.9%, 69.8%, 62.0%, 54.1%, 51.1%, respectively and duodenal ulcer was 28.6%, 27.9%, 33.8%, 37.8% and 40%. And there was evidence of increasing tendency in duodenal ulcer. 6) The most common prevalent site of gastric ulcer in all age was gastric angle. The more old age, the upper stomach was involved. The most favorable site of duodenal ulcer was bulb (81.2%) and pyloric canal(17.4%). 7) The most frequent size of gastric ulcer(34.6%) was from l.0 cm to 1.9 cm. And that of duodenal ulcer was from pinhead to 0. 4cm(50.2%). 8) Among the 408 cases who has been confirmed peptic ulcer by gastroscopy, 219 cases have been taken UGI examination concomitantly. The concordance rate of gastric ulcer, duodenal ulcer svas 70%and 76.9%, respectively.
김영건,정선묵 충남대학교 의과대학 지역사회의학연구소 1983 충남의대잡지 Vol.10 No.2
A clinical analysis was performed in 108 patients with duodenal ulcer who were diagnosed by gastroduodenoscope at the endoscopic room of Chungnam National University Hospital during period from January 1980 to August 1983. The results were as follows : 1. The male to female ratio was 3 : 1, and most prevalent age group was 4th. (29.6%) and 3rd. (24.7%) decade in male, 5th, (40.1%) and 6th decade(29.6%) in female. 2. The subjetive symptoms of duodenal ulcer were epigastric pain(67.6%), heart burning sense (24.1%), dyspepsia (19.4%) etc., in order of frequency. 3. The most common size of ulcer was less than 0.5㎝ in diameter. 4. The active ulcer was most common(62.0%), scar of ulcer 24.1%, healing stage 11.9% in order of frequency. 5. Among the 108 patients who were diagnosed as having ulcer, 53patients were done X-ray examination concomitantly. The rate of same finding on both examinations was 71.7%.