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Ranitidine 의 소화성궤양치료효과에 대한 임상적연구
김영건(Young Kun Kim),윤성열(Sung Yeul Yoon),정현용(Hyeon Yong Jeong),정선묵(Seon Muk Jeong) 대한소화기학회 1983 대한소화기학회지 Vol.15 No.2
N/A This study was performed to assess the clinical therapeutic effectiveness of anti-histamine agent, ranitidine. The drug was given in the dose of 150mg twice a day to 12 cases of gastric ulcer and 11 cases of duodenal ulcer. Initial diagnosis and follow up observation after 4 weeks, 6 weeks and 8 weeks of treatment were made by the upper G-I endoscopy. The results observed are as followings. 1) The male to female ratio of the subject was about 20:3 and the most prevalent age group was the sixth decade of the life in both the gastric and duodenal ulcer groups. 2) The location of gastric ulcer were 7 cases in body and 5 cases in angle of the stomach and duodenal ulcer were 7 cases in bulb and 4 cases in pyloric area. 3) As for the subjective symptoms, epigastric pain, heart-burning sensation, hunger pain, abdominal discomfort, dyspepsia were experienced, and were relieved after 1 week of treatment in 60 80%, and were completely relieved after 4 weeks of treatment in all cases respecti vely. 4) The cumulative rates of complete healing of the gastric ulcer (12 cases) were 75% (9 cases) after 4 week, 92% (11 cases) after 6weeks, 100%(12 cases) after 8 weeks of treatment, and those of the duodenal ulcer (11 cases) were 91%(10 cases) after 4 weeks, 100%(11 cases) after 6 weeks of treatment. 5) The untoward side effect were not found. In conclusion ranitidine appears to be effective and safe for the treatment of patients with peptic ulcer disease.
김삼용,노흥규,신영태,윤성열,이헌영,전병숙 대한핵의학회 1983 핵의학 분자영상 Vol.17 No.1
Fifteen cases of Korean hemorrhagic fever who were admitted Chungnam National University Hospital from October 1981 to December 1981 were analysed on the evaluation of metabolic changes of the thyroid hormones, and thyroid function status in each clinical phase. 1) Serum T₃, T₄ concentration, FT₄I and T₄/TBG ratio were significantly lower (p〈0.001, p〈0.005, P〈0.005, P〈0.001, respectively) than control group in oliguric and early diuretic phase of Korean hemorrhagic fever. With the recovery of illness, abnormal thyroid hormones and thyroid function indices tend to become normal range. But Serum FT₄, TSH anlE TBG concentration were within normal range in all phase of KHF. Thus in Korean hemorrhagic fever, euthyroidism is probably maintained by normal or elevated serum FT₄. 2) T₄/T₃ and rT₃/T₃ rato (p〈0.005, p〈0.005) were increased in oliguric and early diuretic phase of MHF. These results might be explained by decreased peripheral conversion of T₄ to T_3 in oliguric and early diuretic phase.