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결체조직 질환 환자의 모세혈관 변화에 관한 광시야 현미경적 관찰과 그 진단적 의의
홍천수(Chein Soo Hong),정미령(Mi Ryoung Chung),김병철(Byung Chul Kim),이수곤(Soo Kon Lee),허갑범(Kap Bum Huh) 대한내과학회 1989 대한내과학회지 Vol.37 No.5
N/A Twenty-three patients with connective tissue disorders (progressive systemic selerosis, 8 patients; systemic lupus erythermatosus (SLE), 10 patients: Raynaud`s disease, 4 patients; mixed connective tissue disease (MCTI)), 1 patient) were observed for nailfold capillary abnormalities by in vivo widefield microscopy. Enlarged and deformed capillary loops surrounded by relatively avascular areas were found in the nailfolds of all 8 patients with progressive systemic sclerosis, 2 of 10 patients with SLE, 2 of 3 patients with Raynaud`s disease and 1 patient with MCTD. However, no positive correlation was found between the degree of abnormal capillary patterns and extent of organ involvement, These results demonstrate that the widefield microscopic examination of nailfold capillary patterns could be a simple, noninvasive and useful aid in the diagnosis of progressive systemic sclerosis.
한국인 non - A , non - B 간질환에서 C 형 간염바이러스 항체 ( anti - HCV ) 의 검출에 관한 연구
김경희(Kyung Hee Kim),문영명(Young Myoung Moon),정미령(Mi Ryoung Chung),한광협(Kwang Hyup Han),전재윤(Chae Yoon Chon),이관식(Kwan Sik Lee),김원호(Won Ho Kim),이상인(Sang In Lee),강진경(Jin Kyung Kang),박인서(In Suh Park),최홍재(Heung 대한내과학회 1990 대한내과학회지 Vol.39 No.2
N/A An epidemiological study of the hepatitis C virus (HCV) infection and its etiological significance in non- A, non-B acute and chronic liver disease in Korea was performed by testing serum samples from patients for antibody to HCV (anti-HCV). Anti-HCV was detected by enzyme-linked immunoassay (Ortho Diagnostic Systems). 1) Anti-HCV was detected in sera of 3 (30.0%) out of 10 cases with non-A, non-B acute hepatitis. Anti-HCV was detected in 30 (69.7%) out of 43 cases with non-A, non-B chronic hepatitis, and in 9 (60.0%) out of 15 cases with non-A, non-B liver cirrhosis. In 12 (10.2%) out of 118 patients with ESRD in hemodialysis units, anti-HCV was detected. Forty healthy controls and 51 cases with fatty liver had no detectable anti-HCV, and 24 HBsAg carriers were negative in all but one. 2) Three (50.09p) out of six cases with posttransfusion non-A, non-B acute hepatitis were seroconverted, but none of the four cases with sporadic non-A, non-B acute hepatitis were anti-HCV positive. 3) Nine (30.0%) out of 30 anti-HCV positive cases with non-A, non-B chronic hepatitis had a history of blood transfusion and multiple acupuncture. 4) There was no significant difference between anti-HCV positive patients and anti-HCV negative patients with non-A, non-B chronic liver disease in the history of blood transfusion or the liver function test. 5) Seropositivity to HCV was unrelated to the presence of anti-HBc or anti-HBs in patients with liver cirrhosis. We concluded that anti-HCV is colosely associated with non-A, non-B liver disease in Korea, and HCV seems to have a correlation with the etiology and pathogenesis of non-A, non-B liver diseases.
Propylthiouracil 투여중 발생한 간염 3예
김동섭,허갑범,이현철,김경래,정재희,정미령 대한내분비학회 1989 Endocrinology and metabolism Vol.4 No.3
Hepatitis is an uncommon complication of propylthiouracil(PTU) therapy in patients with hyperthyroidism. We experienced three patients with PTU-induced hepatitis. The biochemical pattern of injury was predominantly hepatocellular with elevated transaminase values and the recovery was complete after discontinuation of administraion of PTU. PTU-induced hepatitis must be suspected in cases with clinical or laboratory evidence of hepatocellular dysfunction in any patients receiving PTU. (J. Kor Soc Endocrinol 4:240~246, 1989)