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위장관 위선암의 림프절 전이의 평가에 있어서 면역조직화학적 방법의 의의
이옥재(Ok Jae Lee),정기문(Kee Moon Chung),하우송(Woo Song Ha) 대한소화기학회 2001 대한소화기학회지 Vol.37 No.5
Background/Aims: Lymph node micrometastasis could be detected by immunohistochemical staining but not by conventional H&E staining. We investigated the usefulness of immunohistochemical staining in evaluation of lymph node metastasis, and examined the role of p53 protein expression in the detection of lymph node micrometastasis. Methods: H&E staining and immunohistochemical staining using antibodies against cytokeratin and CEA were performed in 509 lymph nodes resected from 19 patients with gastric adenocarcinomas. The expression of p53 was investigated for primary tumors and 401 lymph nodes obtained from 16 patients with gastic cancer. Results: Metastasis was confirmed in 131/509 (25.7%) lymph nodes by H&E staining, in 186/509 (36.5%) by immunohistochemical staining (cytokeratin, 186; CEA, 30), and in 187/509 (36.7%) by combined analysis. Micrometastasis was identified in 56 lymph nodes (14.8%). Five of seven patients who had H&E-negative lymph nodes showed micrometastasis, and all were poorly differentiated or signet ring cell type and diffuse type of carcinoma. P53 protein was more frequently expressed in metastasis-positive nodes than negative nodes (24.3% vs. 1.2%, p<0.005). However, the expression of p53 was observed in only 7.0% of lymph nodes with micrometastasis. Conclusions: Immunohistochemical staining for cytokeratin is useful for detection of lymph node micrometastasis, especially in poorly differentiated and diffuse type adenocarcinomas. P53 expression in lymph nodes is not so useful for identification of lymph node micrometastasis. (Korean J Gastroenterol 2001;37:327-335)
김영구(Young Koo Kim),문태기(Tae Kee Moon),정기양(Kee Yang Chung),이승헌(Seung Hun Lee) 대한피부과학회 1999 대한피부과학회지 Vol.37 No.9
Microvenular hemangioma (MH) is a recently described, uncommon, acquired vascular, tumor presenting clinically as a small reddish nodule in young and middle, aged individuals of either gender. Histologically, thin and irreguarly branching small venules with inconspicouous lumia and without cellular atypia are found widely throughout the dermis. The presence of histologic features of the collagen dissection and vascular tufts makes it necessary to differentiate MH with Kaposi`s sarcoma and angioblastoma. As we are aware, the description of these two cases which showed the characteristic clinical and histologic features of MH, is the first report of MH in Korea.(Korean J Dermatol 1999;37(9) : 1320∼1324)
이옥재(Ok Jae Lee),심정우(Jung Woo Shim),김현진(Hyun Jeen Kim),김기홍(Kee Hong Kim),정기문(Kee Moon Chung) 대한소화기학회 1997 대한소화기학회지 Vol.30 No.2
Although primary angiosarcoma of the liver is a rare malignant tumor, it is the object of interest because of an association with specific carcinogen such as thorium dioxide, arsenic and vinyl chloride. We present here a case of primary angiosarcoma of the liver found in farmer. A 72-years old man was presented with right upper quadrant abdominal pain. Abdominal ultrasonography and CT scan revealed a mass in the left lobe of the liver and histologic diagnosis of angiosarcoma was made by percutaneous needle biopsy. Follow-up ultrasonography performeci at 8 weeks after discharge against advice increased size of the tumor. (Korean J Gastroenterol 1997; 30: 262-267)
전수일,정기양,문태기,전윤선 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.5
We describe a 23-year-old man showing typically clinical and histological features of targetoid hemosiderotic hemangioma. About 35 cases of this newly-described entity have been reported since the first description by Santa Cruz and Aronherg in 1988. It is important to distinguish these tumors from patch stage Kaposi's sarcoma, retiform hemangioendothelioma and progressive lymphangioma.
출혈위험성이 높은 식도정맥류에 대한 예방적인 내시경적 정맥류 결찰요법
이옥재,정기문 대한소화기내시경학회 1996 Clinical Endoscopy Vol.16 No.4
Prophylactic treatment of varices is an appealing concept because 50% of patients who experience variceal bleeding will die within the first 6 weeks of the first bleeding. However, the majority of trials which have evaluated prophylactic therapy gave failed to demonstrate advantage, We tried prophylactic endoscopic variceal ligation(EVL) in 10 patients, to evaluate the safety and effect of prophylactic EVL for esophageal varices with high-risk of hemorrhage. The eradication rate was 100% without bleeding and mortality, the mean session for eradication of varices 1.9, the number of bands per person 16.9 and the number of bands per session 8.9. Although mild chest pain(5.3%) and chest discomfortness(31.6%) were observed, no serious complication related with EVL resulted from 19 EVL sessions. The patients were followed for a mean of 327.0 days(85-708), during which recurrent esophagea1 varices were found in a case at 260 days from last session, but no bleeding nor death was occured. No late complication of EVL was documented. In conclusion, prophylactic EVL is safe and may be effective for esophageal varices with high-risk of hemorrhage. But, the large controlled-trial should be required.