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영지버섯 생장점 단백다당체 GLB의 대식세포 활성화 효과
오정연(Jung Yeon Oh),조경주(kyung Joo Cho),정수현(Soo Hyun Chung),김진향(Jin Hyang Kim),Hyun S. Lillehoj,정경수(Kyeong Soo Chung) 대한약학회 1998 약학회지 Vol.42 No.3
In the previous study we described the antitumor activity of GLB, a protein-polysaccharide fraction of the growing tips of Ganoderma lucidum, against sarcoma 180 solid tumor in ICR mice. In this study we investigated the stimulatory activity of GLB on macrophages. When analyzed using a flow cytometer, GLB (100mcg/ml) was found to increase the phagocytic activity of the BALB/c mouse peritoneal macrophages as well as chicken macrophage BM2CL cells against FITC-labeled C.albicans by 55.2% and 21.2%, respectively. GLB also increased the spreading and the expression of MHC class II molecules of BM2CL cells as well as the mouse peritoneal macrophages. From these results, it is clear that GLB is a strong stimulator to the macrophages.
이영주 ( Young Joo Lee ),최상태 ( Sang Tae Choi ),김세현 ( Se Hyun Kim ),정경수 ( Kyung Soo Jung ),윤설희 ( Sul Hee Yoon ),정수진 ( Soo Jin Jeung ),이승우 ( Seung Woo Yi ),김주항 ( Joo Hang Kim ) 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.62 No.1
A thymic carcinoma is a rare malignant neoplasm of the thymus epithelium, which can be distinguished from a benign or invasive thymoma. Contrary to a thymoma, the association of a thymic carcinoma and autoimmune disease is rare, with only a few cases having been reported. Herein, a case of thymic carcinoma diagnosed concurrently with systemic lupus erythematosus (SLE) is reported. A 49 year-old man presented at our clinic with myalgia. He was diagnosed with SLE, based on an oral ulcer, lymphopenia, and positive ANA and anti-Sm antibodies. Incidentally, a routine chest X-ray showed a large mediastinal mass. Pathological examination of the mediastinal mass revealed an undifferentiated thymic carcinoma, of WHO classification type C. Further work-up for staging showed multiple bone and lung metastases. With a palliative aim, he received systemic chemotherapy, but refused further chemotherapy after the 2(nd) course. Currently, the patient has not been followed up since the chemotherapy. (Tuberc Respir Dis 2007; 62: 67-70)
영지버섯 생장점 단백다당체 GLB의 대식세포 활성화 효과
오정연,조경주,정수현,김진향,Lillehoj, H.S.,정경수 충남대학교 약학대학 의약품개발연구소 1998 藥學論文集 Vol.14 No.-
In the previous study we described the antitumor activity of GLB. a protein-polysaccharide fraction of the growing tips of Ganoderma lucidum, against sarcoma 180 solid tumor in ICR mice. In this study we investigated the stimulatory activity of GLB on macrophages. When analyzed using a flow cytometer. GLB (100 ㎍/㎖) was found to increase the phagocytic activity of the BALB/c mouse peritoneal macrophages as well as chicken macrophage BM2CL cells against FTTC-labeled C. albicans by 55.2% and 21.2%, respectively. GLB also increased the spreading and the expression of MHC class Ⅱ molecules of BM2CL cells as well as the mouse peritoneal macrophages. From these results, it is clear that GLB is a strong stimulator to the macrophages.