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RISS 인기검색어
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- 저자 : 전철수(Chul Soo Jun) (검색결과 7 건)
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강희동,전철수,이경일,한지환,이형신,최진,허재균,황경태,Kang, Hee-Dong,Jun, Chul-Soo,Lee, Kyung-Yil,Han, Ji-Hwan,Lee, Hyung-Shin,Choi, Jin,Herm, Jae-Kyun,Hwang, Kyung-Tai 대한소아감염학회 2001 Pediatric Infection and Vaccine Vol.8 No.2
Although the incidence of tuberculosis has been decreased, it is still an important community acquired infectious disease in the world. Miliary or disseminated tuberculosis occurs from the inadequacy of host defense in controling tuberculous infection. Generally, brain parenchyme has been considered to be a rare involving organ than other organs or meninges in miliary tuberculosis. However it has been proving that the brain parenchyme is commonly involved organ in miliary tuberculosis even without neurological manifestations. We report a case of 8 yr-old male patient, who was diagnosed as having an miliary tuberculosis with multiple tuberculoma throughout the brain. The tuberculous lesions of lung and brain were nearly cleared within 3 months with anti-tuberculous therapy. With a reveiw of related literatures, we suggest that the patients with miliary tuberculosis should be evaluateded about brain involvement. 속립성 결핵은 개체의 면역이상으로 결핵균이 전신의 장기에 파종될 시 나타난다. 최근에는 뇌조직도 흔히 침범되는 장기의 하나로 인식되고 있으며 뇌조직에서도 다발성 병변을 보이는 것이 일반적이다. 저자들은 두통과 미열을 주소로 입원한 8세 남아에서 방사선학적 소견과 위액 흡입에 의한 배양 결과로 확진된 속립성 결핵과 두개내 다발성 결핵종을 경험하여 문헌 고찰과 함께 보고하였다. 속립성 결핵이 의심되는 경우에 신경학적 증상의 유무에 관계없이 중추신경계의 영상 검사가 필요하다.
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흰쥐에서의 신규 항암제 BR-28702-2 의 체내동태
용철순(Chul Soon Yong),이신웅(Shin Woong Lee),전철수(Chul Soo Jun),채희상(Hee Sang Chai),신원섭(Won Sup Shin),백우현(Woo Hyun Paik) 한국응용약물학회 1995 Biomolecules & Therapeutics(구 응용약물학회지) Vol.3 No.2
The purpose of this study was to determine pharmacokinetic parameters of BR-28702-2, a new antineoplastic agent which is the conjugate of nucleotide and phospholipid, and to compare them with those of ara-C. Male rats were cannulated in the left femoral vein and received a single i.v. bolus dose of either BR-28702-2 or ara-C. BR-28702-2 was also administered i.p, and plasma samples were analyzed by reversedphase HPLC. The t_(½(β)) of ara-C(1.22 hr.) was significantly smaller than that of BR-28702-2(4.420 hr.). The absolute bioavailability of BR-28702-2 after i.p. injection was 1.125%. This lower bioavailability, together with previous reports that marked antineoplastic activity was observed when given i.p., indicates that BR-287022 would act as a depot system to release active moieties. Further works, therefore, need to be done to characterize active metabolites.
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Hepatic Targeting of Acyclovir Using Asialofetuin as a Drug Carrier
용철순,손성호,전철수,오두만,Yong, Chul-Soon,Son, Sung-Ho,Jun, Chul-Soo,Oh, Doo-Man 한국약제학회 1994 Journal of Pharmaceutical Investigation Vol.24 No.4
With the purpose of improving the therapeutic index of $[^3H]$ acyclovir (ACV) in the treatment of chronic hepatitis B infection, asialofetuin (AF) which after selective interaction with Ashwell's receptor specifically enters into hepatocytes, was chosen as a carrier system for hepatic targeting. This drug was first converted to its monophosphate (ACVMP), which was subsequently activated by water soluble carbodiimide to conjugate with ${\varepsilon}-NH_2$ groups of Iysine residues of AF. The molar ratio of ACVMP to AF in the conjugate was 3.9. In rats, elimination of ACVMP-AF conjugate after i.v. injection showed two phase elimination kinetics. Initial apparent elimination rate constant in rats was $0.191\;min^{-1}$ which was greater than that of ACV. The elimination rate constant from terminal phase was $0.021\;min^{-1}$. Area under the total radioactivities versus time curve was found to be several times larger in liver than in other organs (spleen, intestine, lung and kidney) after i.v. administration of the conjugate labelled in the drug moiety. The above results suggested that ACVMP-AF conjugate was rapidly taken up by hepatocytes and could be a useful hepatic targeting system.
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용철순,이신웅,전철수,채희상,신원섭,백우현 영남대학교 약품개발연구소 1995 영남대학교 약품개발연구소 연구업적집 Vol.5 No.-
The purpose of this study was to determine pharmacokinetic parameters of BR-28702-2, a new antineoplastic agent which is the conjugate of nucleotide and phospholipid, and to compare them with those of ara-C. Male rats were cannulated in the left femoral vein and received a single i.v. bolus dose of either BR-28702-2 or ara-C. BR-28702-2 was also administered i.p. and plasma samples were analyzed by reversed-phase HPLC. The t_(L/2(β)) of ara-C(1.22 hr.) was significantly smaller than that of BR-28702-2(4.420 hr.). The absolute bioavailability of BR-28702-2 after i.p. injection was 1.125%. This lower bioavailability, together with previous reports that marked antineoplastic activity was observed when given i.p., indicates that BR-28702-2 would act as a depot system to release active moieties. Further works. therefore, need to be done to characterize active metabolites.
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Hepatic Targeting of Acyclovir Using Asialofetuin as a Drug Carrier
Yong, Chul Soon,Son, Sung Ho,Jun, Chul Soo,Oh, Doo-Man 영남대학교 약품개발연구소 1995 영남대학교 약품개발연구소 연구업적집 Vol.5 No.-
With the purpose of improving the therapeutic index of [³H] acyclovir (ACV) in the treatment of chronic hepatitis B infection, asialofetuin (AF) which after selective interaction with Ashwell's receptor specifically enters into hepatocytes, was chosen as a carrier system for hepatic targeting. This drug was first converted to its monophosphate (ACVMP), which was subsequently activated by water soluble carbodiimide to conjugate with ε-NH₂ groups of lysine residues of AF. The molar ratio of ACVMP to AF in the conjugate was 3.9. In rats, elimination of ACVMP-AF conjugate after i.v. injection showed two phase elimination kinetics. Initial apparent elimination rate constant in rats was 0.191 min^(-1) which was greater than that of ACV. The elimination rate constant from terminal phase was 0.021 min^(-1) . Area under the total radioactivities versus time curve was found to be several times larger in liver than in other organs (spleen, intestine, lung and kidney) after i.v. administration of the conjugate labelled in the drug moiety. The above results suggested that ACVMP-AF conjugate was rapidly taken up by hepatocytes and could be a useful hepatic targeting system.
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아시알로페투인을 약물수송체로 이용한 아시클로버의 간표적화
용철순,손성호,전철수,오두만 한국약제학회 1994 Journal of Pharmaceutical Investigation Vol.24 No.4
With the purpose of improving the therapeutic index of [³H] acyclovir (ACV) in the treatment of chronic hepatitis B infection, asialofetuin (AF) which after selective interaction with Ashwell's receptor specifically enters into hepatocytes, was chosen as a carrier system for hepatic targeting. This drug was first converted to its monophosphate (ACVMP), which was subsequently activated by water soluble carbodiimide to conjugate with ε-NH₂ groups of lysine residues of AF. The molar ratio of ACVMP to AF in the conjugate was 3.9. In rats, elimination of ACVMP-AF conjugate after i.v. injection showed two phase elimination kinetics. Initial apparent elimination rate constant in rats was 0.191 min¹ which was greater than that of ACV. The elimination rate constant from terminal phase was 0.021 min¹. Area under the total radioactivities versus time curve was found to be several times larger in liver than in other organs (spleen, intestine, lung and kidney) after i.v. administration of the conjugate labelled in the drug moiety. The above results suggested that ACVMP-AF conjugate was rapidly taken up by hepatocytes and could be a useful hepatic targeting system.
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