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해양심층수 전해질 보충이 고온 환경에서 일회성운동 중 혈중 전해질 농도 및 운동수행력에 미치는 영향
박세환(Se Hwan Park),전병엽(Byeong Yeob Jeon),김용환(Yong Hwan Kim),윤진환(Jin-Hwan Yoon) 한국생활환경학회 2016 한국생활환경학회지 Vol.23 No.6
This study investigated the effect of deep sea water electrolyte drink supplement on blood electrolyte concentration and exercise performance during acute exercise in hot environment. This study has selected 11 healthy males (23±1.8 years; 65.9±6.92 kg; 172.5±6.9 cm) as the subjects. Exercise protocol was conducted on a treadmill (30°C±2 /all-out) by using Bruce protocol. Blood sample were obtained at baseline, immediately and 30 min post-exercise. The source variables of blood electrolyte elements were Na<SUP>+</SUP>, Cl<SUP>-</SUP>, K<SUP>+</SUP> and blood lactate, ADH. The source variables of exercise performance were total exercise time and VO2max. The results of this study were as follows; First, the blood electrolyte elements were increased by deep-sea water compared with water intake, but not significantly. Second, blood lactate and ADH were increased deep-sea water compared with water intake, but not significantly. On the other hand, both of exercise time and VO2max were significantly increased in deep-sea water intake (p<.05). Deep-sea water electrolyte supplement intake didn’t have a significant difference on the change in blood electrolyte concentration, it showed higher level of electrolyte concentration compared with water intake. Therefore, further study should be conducted under the condition of long-time intake. Meanwhile, deep-sea water electrolyte supplement intake is considered to enhance exercise time and VO2max. Thus it can be said to have a positive effect up on exercise performance in hot environment.
Atorvastatin으로 유도된 근위축 세포모델에서 상황-오미자박 고상발효물 열수추출물의 보호효과
김영숙,황수진,박광일,임종민,천다미,정유진,전병엽,곽경태,오태우,Kim, Young-Suk,Hwang, Su-Jin,Park, Kwang-Il,Lim, Jong-Min,Cheon, Da-Mi,Jung, Yu Jin,Jeon, Byeong Yeob,Kwak, Kyeung Tae,Oh, Tae Woo 대한한의학방제학회 2021 大韓韓醫學方劑學會誌 Vol.29 No.4
Objectives : This study is to effect of improving muscle atrophy through water extract on the solid-phase fermentation extraction with Phellinus linteus of discarded Schisandra chinensis in an atorvastatin-induced atrophy C2C12 cell. Methods : C2C12 myoblast were differentiated into myotube by 2% horse serum medium for 6 days, and then treated solid-phase fermentation(S-P) extract at different concentrations for 24h. To investigate the effect of S-P extract on the induction of muscle atrophy and expression of atrophy-related genes and apoptosis in differentiated C2C12 myotubes using a GSH, ROS, real-time PCR, western blots analysis. Results : As a result of treatment with atorvastatin at concentrations of 5, 10, and 20 uM on the 6th day of differentiation in C2C12 myotube cells, it was confirmed that the cell morphology was damaged in a concentration-dependent manner, and the length and thickness of the myotube also decreased in a concentration-dependent manner. Treatment with S-P extract (50, 100 and 200 ㎍/㎖) increased of GSH and inhibited ROS in the atorvastatin-induced muscle atrophy cell model at a concentration that did not induce toxicity. In addition, it was confirmed that it has an effect on muscle reduction by inhibiting apoptosis of muscle cells as well as being involved in protein production and degradation of muscle cells. Conclusions : Atorvastatin-induced atrophy C2C12 cell, S-P extract activates related to differentiation/generation and proteolysis, and inhibits cell death of atrophy in C2C12 cell. Based on this, it is necessary to prove its effectiveness through animal models and human application test, but it is considered to be discarded Schisandra chinensis can present the potential for development as a recycling industrial material.