http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 장현규(Hyun Kyoo Jang) (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
배상철(Sang Cheol Bae),정성수(Sung Soo Jung),송관규(Gwan Gyu Song),이인홍(In Hong Lee),장현규(Hyun Kyoo Jang),유대현(Dae Hyun Yoo),김성윤(Seong Yoon Kim),김신규(Think You Kim) 대한내과학회 1993 대한내과학회지 Vol.45 No.5
N/A Objectives: The antiphospholipid antibodies (APA) are associated with a clinical syndrome of vascular thrombosis, thrombocytopenia, recurrent fetal loss and neurological manifestations. This has been studied by several investigators for systemie lupus erythematosus but no systematic study has been reported for the correlation between a variety of systemic rheumatic diseases including rheumatoid arthritis and antiphospholipid antibodies in Korea. Methods: Authors have used enzyme-linked im-munosorbent assay (ELISA) to detect antibodies to phopholipids and studied the frequencies of antibodies to these antigens and their correlation with clinical and laboratory features in systemic rheumatic diseases. Resulta: 1) 206 patients were investigated for the presence of antibodies to phopholipids and 25 out of 206 patients (12. 1%) had antiphospholipid antibodies. 2) The frequencies of antibodies to phopholipids were 20.7% in patients with systemic lupus erythematosus, 12.3% in rheumatoid arthritis and 16.7% in mixed connective tissue dsease but antibodies to phospholipids were not detected in ankylosing spondylitis, polymyositis/ dermatomyositis, undifferentiated connective tissue disease and Behcet's disease. 3) In patients with systemic lupus erythematosus, no significant association was found between antiphos-pholipid antibodies and clinical and laboratory features except thrombocytopenia and anti-Ro antibody (p=0.003, p=0.036). But patients with antiphopholipid antibodies were likly to have a higher incidence of malar rash, photosensitivity, alopecia, neurologic manifestation, renal disorder, fetal loss and thrombosis than those without antiphospholipid antibodies. 4) In patients with rheumatoid arthritis, no significant association was found between antiphospholipid antibodies and clinical and laboratory features. Conclusions: These results showed that the detection of antibodies to phospholipids by ELISA was expected to be useful as a screening test and suggested that antiphospholipid antibody found in rheumatoid arthritis patients differed from that seen in systemic lupus eryth-ematosus patients. Further studies into the fine specificity of antiphospholipid antibody in various systemic rheumatic diseases are needed.
-
장현규,이인홍,배상철,유대현,김성윤,김신규 한양대학교 의과대학 1993 한양의대 학술지 Vol.13 No.1
Systemic lupus erythemaltosus and other rheumatic diseases are characterized by a diverse antibody production which is generally not organ or receptor specific. Among these autoantibodies, the antiphospholipid antibodies (APA) are associated with a clinical syndrome of vascular thrombosis, thrombocytopenia, recurrent fetal loss and neurologicla manifestations. This has been studied by several investigators for systemic lupus erythematosus but on systematic study has been reproted for the correlation between a variety of systemic rheumatic diseases including rheumatoid arthritis and antiphospholipid antibodies in Korea. In this study, author has used enzyme-linked immunosorbent assay (ELISA) to detect antibodies to phopholipids and studied the frequencies of antibodies to these antigens and their correlation with clinical and laboratory features in systemic rheumatic diseases. The results were as follows: 1. 206 patients were investigated for the presence of antibodies to phopholipeds and 25 out of 206 patients(12.1%) had antiphospholipid antibodies. 2. The frequencies of antibodies to phopholipids were 20.7% in patients with systemic lupus erythematosus, 12.3% in rheumatoid arthritis and 16.7% in mixed connective tissue disease but antibodies to phospholipids were not detected in ankylosing spondylitis, polymyositis'dermatomyositis, undifferentialted connective tissue disease and Behcet's disease. 3. In patients with systemic lupus erythematosus, no significant association was found between antiphosopholipid antibodies and clinical and laboratory features except thrombocylopenia and anti-Ro antibody (p=0.003. p=0.036). But patients with antiphopholipid antibodies were likely to have a higher incidence of malar rash, photocensitivity, alopecia, neurologic manifestation, renal disorder, fetal loss and thrombosis than those without antiphospholipid antibodies. 4. In patients with rheumatoid arthritis, no significant association was found between antiphospholipid antibodies and clinical and laboratory features. These results showed that the detection of antibodies to phospholipids by ELISA was expected to be useful as a screening test and suggested that antiphospholipid antibody found in rheumatoid arthritis patients differed from that seen in systemic lupus erythematosus patients. Further studies into the fine specificity of antiphospholipid antibody in various systemic rheumatic diseases are needed.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
