형광기관지경의 미래

장태원,Jang, Tae-Won 대한기관식도과학회 2009 大韓氣管食道科學會誌 Vol.15 No.2

Lung cancer could be developed through a series of morphological changes from dysplasia to carcinoma in situ and then invasive cancer. However, precancerous lesions are generally a few cell layers thick and are detected only by chance. Autofluorescence bronchoscopy(AFB) is one of the newly developed diagnostic tools to detect the pre-cancerous lesions m the bronchial tissue. Several studies have shown that AFB improved the rate of detection of cancer and dysplastic lesions of the airway, especially those in intraepithelial stage. However, there were high rates of false positive with AFB, and it is also important to develop non-biopsy methods because of lack of accurate information of variable course of preneoplastic lesions regarding progression. So, many other technologies were developed, such as narrow band imaging(NBI), endobronchoscopic ultrasound, optical coherence tomography, and confocal fluorescence microendoscopy. Among the new machines, NBI is a new optical technology that can clearly visualize the microvascular structure m the mucosal layer. NBI seems to increase specificity without compromising sensitivity. In the future such techniques would make it possible to precisely study in detail the natural history of the premalignant epithelium.

목재 부후균의 리그닌 분해효소 활성과 염료 화합물의 탈색

장태원,전상철,안태석,김규중,Jang, Tae-Won,Jun, Sang-Cheol,Ahn, Tae-Seok,Kim, Kyu-Joong 한국미생물학회 2006 미생물학회지 Vol.42 No.1

목재부후균은 리그닌 분해효소로 lignin peroxidase (LIP), Mn-peroxidase (MNP) 및 laccase를 생성하는데 균류에 따라 위의 효소중 하나 혹은 둘 이상의 효소를 분비하거나 전혀 생성하지 않는 균도 있다. 본 실험은 이러한 목재 부후균의 효소생성 양상과 몇 종의 염료화합물 탈색과의 상관관계를 조사하고자 하였다. 조사한 23종 36균주 중 MNP 생성균은 30균주였으며 LIP 혹은 laccase 생성균은 각각 11균주와 12균주였다. 또한 같은 종에서도 효소활성은 다양한 양상을 보여 주었다. 리그닌 분해효소 활성과 비교하여 염료 탈색 정도는 세 효소가 모두 분비되는 백색 부후균의 경우 염료 탈색율이 상대적으로 우수하였고 균주에 따라 차이가 있으나 MNP 활성만을 갖는 균주의 경우, poly R-478 polymeric dye 및 anthron-type dye 인 remazol brilliant blue R염료는 효소 활성도와 다소 유연관계를 보였으며 methylene blue, bromophenol blue및 congo red 염료는 위의 효소들과는 직접적인 관련이 없는 것으로 판단되었으며, 오히려 균사의 생장과 비례하여 탈색율을 나타냈다. LIP, MNP 및 laccase 효소활성이 거의 검출되지 않은 갈색 부후균에서는 bromophenol blue를 제외하고는 염료의 탈색이 10%미만 혹은 전혀 탈색이 되지 앓았다. Wood-rot fungi produce extracellular lignin-degrading enzymes, the best known of which are lignin peroxidase, Mn-peroxidase and laccase. In this experiment, some of them produced all of three enzymes. Many other wood-rot fungi produced one or two of those enzymes with various combinations. In this experiment, we tried to clarify the relationship between the pattern of enzyme production and degradative activity of several dye compounds. From the 36 strains of 23 species of wood-rot fungi, Mn-peroxidase activity was found in 30 strains of the fungi tested, whereas the activity of lignin peroxidase and laccase was detected in 11 strains and 12 strains of species, repectively, in Kirks low nitrogen media. In relation to the activity of lignin degrading enzymes and degradation of dye compounds, the white-rot fungi with three kinds of enzymes tested showed the best dye decolorizers. The fungi with Mn-peroxidase activity only decolorized poly R-478 and remazol brilliant blue R dye in proportion to the enzyme activity, while methylene blue, bromophenol blue and congo red dye were degraded in regardless of enzyme activity. Those dyes were degraded in relation to the growth rate of mycelium. Brown-rot fungi did not degrade all the dye compounds except bromophenol blue, in spite of moderate growth rate.

직업성 질환I - 소방공무원의 건강관리

장태원,Jang, Tae-Won 대한산업보건협회 2020 산업보건 Vol.387 No.-

직업성 질환 - 우정사업 종사자의 건강관리

장태원,Jang, Tae-Won 대한산업보건협회 2020 산업보건 Vol.386 No.-

선박조립분야에 있어 고속용접 현황 및 전망

장태원,문종현,윤동렬,Jang Tae-Won,Moon Jong-Hyun,Yoon Dong-Ryeol 대한용접접합학회 2004 대한용접·접합학회지 Vol.22 No.6

누출성 흉수 대 삼출성 흉수

장태원 ( Tae Won Jang ) 대한내과학회 2011 대한내과학회지 Vol.81 No.2

Pleural effusions are common and of highly diverse etiologies. These effusions can form based on disease of the pleural membranes themselves or of thoracic or abdominal organs. In initial approach, these effusions can be separated as exudates or transudates with Light`s criteria. Exudative pleural effusions meet at least one of the following criteria, whereas transudative effusions meet none: pleural fluid protein-to-serum protein ratio of more than 0.5, pleural fluid lactate dehydrogenase (LDH)-to-serum LDH ratio of more than 0.6, and pleural fluid LDH more than two thirds of the upper normal limit for serum. If apatient appears to have clinically a transudative effusion, additional tests can be assessed to verify its transudative etiology. Congestive heart failure and cirrhosis are responsible for almost all transudative pleural effusions. However, it has been determined that the patient has an exudative pleural effusion, one should attempt to determine which of the diseases, remembering that pneumonia, malignancy, and tuberculosis account for the great majority of all exudative pleural effusions. In all patients with undiagnosed exudative pleural effusions, the appearance of the fluid should be noted, and the pleural fluid protein and LDH levels, glucose level, differential cell count, and microbiologic and cytologic studies should be obtained. In selected patients, other tests on the pleural fluid, such as pH, amylase level, antinuclear antibody level, rheumatoid factor level, adenosine deaminase, lipid analysis, and so forth, may be of value. (Korean J Med 2011;81:135-142)

중국어 否定接頭反義語의 통시적 고찰

장태원(Tae Won Jang),최중식(Jung Sik Choi) 언어과학회 2005 언어과학연구 Vol.34 No.-

미선나무 미성숙 종자의 항산화 및 미백 활성

장태원(Tae Won Jang),박재호(Jae Ho Park) 한국생명과학회 2017 생명과학회지 Vol.27 No.5

미선나무 미성숙 종자는 물푸레나무과의 관목으로 전세계적으로 1속 1종의 중요한 식물자원이다. 대한민국에서는 미선나무 자생지를 보존하고 멸종위기식물로 보호하고 있다. 이러한 이유로 미선나무 미성숙 종자에 대한 연구는 미비하다. 본 연구에서 미선나무 미성숙 종자의 항산화 활성과 미백 관련 단백질인 tyrosinase, TRP-1, TRP-2, MITF의 단백질 발현 및 mRNA 수준의 발현 억제 활성을 확인하였다. 미선나무 미성숙 종자는 활성산소종에 효과가 뛰어났으며, 활성산소종은 노화, 염증, 암 등 다양한 질병을 야기시킨다. 항산화 활성은 DPPH, ABTS 라디칼 소거활성 및 환원력을 평가하였으며, 이러한 활성은 페놀류 화합물과 관계가 있는 것으로 알려져 있다. 페놀류 화합물은 천연 폴리페놀이라고 불리는 파이토케미칼로서 다양한 환경적 요인에 의한 식물 방어 기작의 일환으로 생성되는 2차 대사산물이다. 페놀류 화합물은 노화, 항암을 포함한 많은 인간의 건강에 긍정적인 영향을 준다고 알려져 있다. 미선나무 미성숙 종자는 tyrosinase, TRP-1, TRP-2 단백질 및 mRNA를 조절하였으며, 이러한 요인은 멜라닌 생합성에 중요한 역할을 한다. 또한 microphthalmia-associated transcription factor (MITF)의 단백질 및 mRNA를 억제하였다. MITF는 Tyrosinase, TRP-1, TRP-2의 발현과 전사에 연관된 인자로 알려져 있다. 미선나무 미성숙 종자의 미백활성, 페놀류 화합물, 항산화 활성 사이의 연관관계를 확인하였으며, 결론적으로 미선나무 미성숙 종자는 천연 식물 자원으로부터 얻을 수 있는 항산화제 및 피부 미백을 위한 기능성 화장품 원료로 사용될 수 있다. Abeliophyllum distichum Nakai is deciduous shrubs of flowering plant in Oleaceae. It is important plant resources and consists of one species in the world. Also the endemic plant of A. distichum has been protected and designed endangered plant in Korea. For this reason, study on the immature seeds of A. distichum (ADS) hasn’t progressed. In the present study, we evaluated the antioxidant activity and inhibitory effects on proteins and mRNA levels were related in the whitening effect in B16F10 cells. ADS was effective for reaction oxygen species (ROS). ROS causes various diseases such as aging, inflammation, cancer, and etc. Antioxidant properties were evaluated DPPH, ABTS radical scavenging activity and Reducing power. Plants were known that contained phenolic compounds were related in antioxidant activity. Phenolic compounds were phytochemicals commonly named natural polyphenols. These are secondary metabolites of plants involved in the defense against different types of stresses. In results, ADS suppressed the expression and transcription of Tyrosinase, TRP-1, TRP-2, and Microphthalmia-associated transcription factor (MITF). Tyrosinase, tyrosinase-related protein 1 (TRP-1), tyrosinase-related protein 1 (TRP-2) are known to play an important role in melanin biosynthesis. MITF regulated the expression and transcription of Tyrosinase, TRP-1, and TRP-2. In conclusion, ADS was effective in both antioxidant activities and whitening effects. Also, they were associated with the content of phenolic compounds. We suggested that ADS can be use antioxidants and skin-whitening functional cosmetics material derived from natural plant resources.

從結果補語到完成貌的演變

장태원(Tae Won Jang) 언어과학회 2002 언어과학연구 Vol.23 No.-

The purpose of this study is to refute Zhao`s claim that LE(了) has been brought about from LAI(來) through the state of weakening in "verbness," and to present the results of corpus analyses from the Tang Dynasty to the modern Chinese texts. Although LAI has the meaning of change and development, it has its own system of development and it is different from LE. In Present-Day Chinese Marker LE that denotes a perfective aspect has originated from LIAO(了) through the latter`s verbness being weakened.

괴화와 괴각 에틸아세테이트 분획물의 항산화 및 산화적 DNA 손상 억제 활성

장태원 ( Tae Won Jang ),김예랑 ( Ye Rang Kim ),이승현 ( Sung Hyeon Lee ),김도완 ( Do Wan Kim ),박재호 ( Jae Ho Park ) 대한본초학회 2015 大韓本草學會誌 Vol.30 No.2

Objectives : In this study, we demonstrated the antioxidant activities and the inhibitory effect on oxidative DNA damage of ethyl acetate fractions extracted from Sophorae Flos and Sophorae fructus. Methods : Sophorae Flos and Sophorae fructus were extracted with methanol(MeOH) and divided to Petroleum ether, Ethyl acetate(EtOAC) and Water fraction. The antioxidant activities were conducted by the 1,1-diphenyl-2-picryl hydrazyl(DPPH) radical, 2, 2``-Azine-bis(3-ethylbenzothiazoline-6 sulfonic acid) diammonium salt(ABTS) radical scavenging assay, Fe2+ chelating assay and Reducing power assay. The inhibitory effect of DNA damage were characterized on φX-174 RF I plasmid DNA cleavage assay. In addition, we analyzed the Total phenol contents and the Vitamin C contents of Sophorae Flos and Sophorae fructus. Results : The results of DPPH were 92.71% and 94.72%, ABTS were 87.16% and 62.44%, and Fe2+ chelating were 95.81% and 85.11% at 200㎍/㎖of Sophorae Flos and Sophorae fructus respectively. The Sophorae Flos showed stronger effect than Sophorae fructus in Reducing Power assay. Total phenol content was 111.77 ㎎/g and 122.54 ㎎/g, and Vitamin C content was 2.59 ㎎/g and 3.03 ㎎/g. Also both Sophorae Flos and Sophorae fructus have inhibitory antioxidant effect on φX-174 RF I plasmid DNA cleavage assay. Conclusions : Over all, this study suggests that Sophorae Flos and Sophorae fructus can be used as not only effective antioxidant but also natural medicine.