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장지은 ( Ji Eun Chang ),이지수 ( Ji Soo Lee ),이나란히 ( Naranhi Lee ),조영주 ( Young Joo Cho ),이선화 ( Sun Hwa Lee ) 대한류마티스학회 2002 대한류마티스학회지 Vol.9 No.1
Among the connective tissue diseases, Behct`s disease (BD) outrank systemic lupus erythematosus as a cause of venous occlusive disease. Deep vein thrombosis and superficial thrombophlebitis of the lower extremities are the most common venous lesions found in BD. We report a rare case of superficial venous thrombosis and thrombophlebitis of the abdomen, which was misdiagnosed as superficial mass in a previously undiagnosed BD patient.
무릎 골관절염 환자에서 Hyaluronic Acid의 관절강 내 주입 후 일어나는 국소 반응
장지은 ( Ji Eun Chang ),조영주 ( Young Joo Cho ),이지수 ( Ji Soo Lee ) 대한류마티스학회 2003 대한류마티스학회지 Vol.10 No.3
Objective: To describe the frequency and the nature of acute local reactions following intraarticular hyaluronate injection. Methods: Retrospective review of patients with osteoarthirtis of the knee treated with intraarticular hyaluronate injection between June, 2001 and March, 2002. The frequency, symptoms and signs, and duration and treatment of the local reactions were analyzed. Results: Nineteen patients received 124 hyaluronates injections to knees. Seven (36.8%) patients developed local reactions in 9 (7.3%) knees. Transient pain occurred in 3 patients. However, persistent pain accompanied by swelling developed in 4 patients. Patients who developed transient pain did not required treatment with self-limiting course, but patients with joint swelling required arthrocentesis and intraarticular corticosteroid injection. Conclusion: Intraarticular hyaluronate injection was associated with significant local reactions. Local reactions were more frequent and severe than previously described with occasional development of joint swelling requiring arthrocentesis.
류마티스 관절염 환자에서 저용량 메토트렉세이트 치료 시 혈장 호모시스테인의 농도 변화
장지은 ( Ji Eun Chang ),이지수 ( Ji Soo Lee ),정화순 ( Wha Soon Chung ),이미애 ( Mi Ae Lee ) 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.1
Objective: To determine the effect of short term methotrexate (MTX) therapy and subsequent folic acid (FA) supplementation on plasma homocysteine (p-homocysteine) levels in patients with rheumatoid arthritis (RA). Methods: Sixteen RA patients treated with low dose MTX (10 mg/week) were prospectively studied for 8 weeks. Sixteen age and sex matched healthy individuals were included for control. Serial p-homocysteine levels were determined before the initiation of MTX, 4 weeks after the MTX treatment, and further 4 weeks after FA supplementation. FA and vitamin B12 levels were determined before MTX treatment. Results: Baseline p-homocysteine levels were not significantly different between the RA patients and the controls (7.63 vs 8.40μmol/L). However, in patients with RA, FA levels negatively correlated with the baseline p-homocysteine levels (p=0.009), whereas this negative correlation was not found in the controls. RA patients showed increased tendency in homocysteine levels after MTX treatment without folic acid supplementation but did not reach statistically significance (8.4 vs. 9.06μmol/L, p=0.57). With FA supplementation, the p-homocysteine levels significantly decreased to the level lower than the baseline value before treatment (8.40 vs. 7.05μmol/L, p=0.004). Conclusion: Folic acid nutriture is an important factor in determining baseline p-homocysteine levels. Folic acid supplementation during low dose MTX therapy result in decrease in p-homocysteine level, thereby, may be helpful to decrease the cardiovascular risk in patient with RA receiving MTX.
관해에 도달한 류마티스 관절염 속발성 유전분증에 의한 난치성 설사
권정미 ( Jung Mi Kwon ),장지은 ( Ji Eun Chang ),이지수 ( Ji Soo Lee ),조영주 ( Young Joo Cho ),정성애 ( Seong Ae Chung ),한운섭 ( Woon Sup Han ) 대한류마티스학회 2003 대한류마티스학회지 Vol.10 No.1
Intractable diarrhea associated with secondary amyloidosis in rheumatoid arthritis (RA) is a serious clinical entity with poor prognosis. We describe a 39-year-old male RA patient who presented with intractable diarrhea. Biopsy findings of terminal ileum and colon revealed amyloidosis secondary to RA. Effective treatment of rheumatoid arthritis resulted in remission of intractable diarrhea caused by amyloid protein deposition.
다발성 단신경염을 초기증상으로 발현한 전신성 홍반성 루푸스
김수현 ( Su Hyun Kim ),장지은 ( Ji Eun Chang ),이지수 ( Ji Soo Lee ) 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.4
Mononeuritis multiplex is a peripheral neuropathy characterized by degeneration of one or more named nerve trunks in association with the systemic vasculitides. Mononeuritis multiplex occurs rarely in systemic lupus erythematosus (SLE) patients and usually develops as a late complication of the disease. When mononeuritis multiplex occurs as a presenting feature of SLE, the diagnosis is often delayed causing considerable morbidity. We describe a patient who presented with mononeuritis multiplex as an initial manifestation of SLE.
데이터 출처 유형에 따른 중학생의 소집단 논변활동의 인식론적 수준
조현아 ( Hyun A Cho ),장지은 ( Ji Eun Chang ),김희백 ( Heui Baik Kim ) 한국과학교육학회 2013 한국과학교육학회지 Vol.33 No.2
본 연구는 탐구 맥락에서 실시된 논변활동 과정에서 학생들이 이용하는 데이터 출처에 따라 학생의 인식론적 추론과 논변의 구조가 어떻게 달라지는지 알아보기 위해 수행되었다. 이를 위해 중학교 1학년 ``식물의 영양`` 단원에서 1차 데이터를 이용하는 3가지 논변 과제와 2차 데이터를 이용하는 3가지 논변 과제를 개발하여 적용하였다. 연구 결과, 논변활동 과정에서 나타난 학생들의 인식론적 추론은 데이터 출처에 따라 다르게 나타났다. 1차 데이터를 이용한 논변활동에서는 대부분 현상기반추론이나 관계기반추론을 통해 설명을 구성하였지만 2차 데이터를 이용한 논변활동에서는 모든 소집단이 모형기반추론을 포함하여 설명을 구성해 나갔다. 현상기반추론이나 관계기반추론을 바탕으로 작성된 논변의 경우, 학생들은 관찰 가능한 특징만을 기술하였고 논변에서 보장이 생략되는 경우가 많았다. 반면 모형기반추론을 포함한 논변의 경우 관찰 결과를 이론 지식과 결합하여 설명을 구성해가고 논변에서 보장이 보다 잘 드러났다. 그리고 이 때, 소집단 내에서는 더욱 다양한 아이디어가 제안되었고 이에 대한 평가 맥락이 형성되면서 논변활동을 더욱 자극하였다 This study is conducted to examine how epistemic reasoning and argument structures of students vary according to data sources used in the process of argumentation implemented in the context of inquiry. To this end, three argument tasks using first-hand data and three argument tasks using second-hand data were developed and applied to the unit on ``Nutrition of plants`` for first year middle school students. According to the results of this study, epistemic reasoning of students manifested during the process of argumentation and varied according to data sources. While most students composed explanations with phenomenon-based or relation-based reasoning in argumentation using first-hand data, all the small groups composed explanations that included model-based reasoning in argumentation using second-hand data. In the case of arguments including phenomenon-based or relation-based reasoning, students described only observable characteristics, with warrants omitted from arguments in many cases. On the other hand, in the case of arguments that included model-based reasoning, explanations were composed by combining the results of observations with theoretical knowledge, with warrants more apparent in their arguments.