http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
JiYong Lee(이지용),SeungHyun Park(박승현),Eui Hwa Jang(장의화),Jung-Hwan Kim(김정환),Young-Nam Youn(윤영남),WonHyoung Ryu(류원형) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.4
Neointimal hyperplasia (NIH), which is a commonly followed complication after cardiovascular surgery, leads to abnormal proliferation of smooth muscle cells in the tunica media due to endothelial damages and inflammatory response, resulting in restenosis and occlusion. For enhanced delivery of anti-proliferation drug to the tunica media with localized way, perivascular microneedle (MN) devices have been developed including MN cuff and wrappable MN mesh using biodegradable PLGA, showing enhanced NIH reduction with perivascular penetration. However, their tensile property including Young’s modulus and elongation needed to be modified to minimize mechanical constriction to the vascular tissue for vascular integrity. In this study, highly stretchable silk MN mesh was developed and their feasibility was evaluated with ex vivo insertion tests for localized drug delivery to the tunica media. The mechanical interaction between silk MN and rabbit abdominal aorta was analyzed with both infinite and blood pulse modeled insertion tests and tunica adventitia penetrability, an epidermal layer of the aorta, was evaluated with histopathological demonstration. As a result, tunica adventitia penetration was induced with 100 repetitive pulsatile movements with 3.58 mN of initial insertion and 3.56 mN of pulsatile induced force. Finally, in vivo comparative animal study was performed by applying silk MN mesh to the endothelially damaged blood vessel and showed enhanced efficacy for NIH reduction with multiple vascular penetrations.