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건강한 여성 근로자에서 Apolipoprotein E와 혈중 지질 농도와의 관련성
문기은,성숙희,장윤균,박일근,백윤미,김수근,최태인,진영우,Moon, Gi-Eun,Sung, Sook-Hee,Chang, Youn-Koun,Park, Il-Keun,Paek, Yun-Mi,Kim, Soo-Geun,Choi, Tae-In,Jin, Young-Woo 대한예방의학회 2010 예방의학회지 Vol.43 No.3
Objectives: Plasma lipid profiles and Apolipoprotein E (ApoE) are established risk factors for cardiovascular disease (CVD). The knowledge of lipid profile may estimate the potential victims of cardiovascular disease before its initiation and progression and offers the opportunity for primary prevention. The most common ApoE polymorphism has been found to influence plasma lipid concentrations and its correlation with CVD has been extensively investigated in the last decade. Methods: The ApoE polymorphism and its influence on plasma lipid were investigated in healthy woman workers. The information on confounding factors was obtained through a self-administered questionnaire and ApoE polymorphism was investigated using PCR. Results: The relative frequencies of alleles E2, E3 and E4 for the study population (n = 305) were 0.127, 0.750 and 0.121, respectively. ApoE polymorphism was associated with variations in plasma HDL-cholesterol lipid profile. In order to estimate the independent effects of alleles E2 and E4, as compared with E3, on lipid profile, multiple regression was performed after adjustment for confounding variables such as age, BMI, blood pressure, education status, insulin, fasting glucose, HOMA-IR, menopause. ApoE2 had a negative association with HDL cholesterol and ApoE4 had a positive association with LDL cholesterol. Conclusions: This study identified that the ApoE and CVD risk factors contribute to the lipid profiles, similar to other studies. The analysis including dietary intake and other gene in further studies may help to identify clear effects on lipid profiles as risk factor for CVD.
남경희(Nam, Kyung-Hui),강지연(Kang, Ji-Yeon),이연주(Lee, Yeon-Ju),성숙희(Sung, Sook-HeeChang),장윤균(Youn-Koun),이지영(Lee, Ji-Young),박일근(Park, Ill-Keun),최태인(Choi, Tae-In) 한국영양학회 2013 Journal of Nutrition and Health Vol.46 No.2
본 연구는 대사증후군 관리를 위한 12주 중재 프로그램으로, 실천지침 이행 정도에 따라 생활습관 변화, 영양소 섭취, 대사증후군 위험인자에 미치는 영향을 알아보고자 하는 목적으로 수행되었다. 1) 연구 대상자는 대사증후군을 가진 남성 근로자로, 모두 기혼자였으며, 교육수준은 높은 편이었다. 12주 중재 프로그램 후 영양성분표시 활용 정도가 유의하게 증가하였으며 과일의 1일 1회 분량 섭취 빈도가 증가하였다. 2) 실천지침 이행률에 따른 신체계측 변화를 살펴보면, 저이행군은 이완기혈압이 감소하였고, 중이행군은 허리둘레의 유의한 감소가 있었다. 고이행군은 수축기혈압, 이완기혈압, LDL콜레스테롤 수치가 유의하게 감소하였고, 고이행군의 수축기혈압과 이완기혈압, LDL콜레스테롤의 변화량은 중이행군보다 유의하게 큰 것으로 나타났다. 3) 저이행군은 단백질과 소금 섭취량, 단백질과 지방의 섭취 비율이 유의하게 감소하였다. 중이행군은 총 열량, 비타민 C의 유의한 감소가 있었으며, 고이행군은 총 열량의 유의한 감소가 있었다. 고이행군은 중이행군에 비해 식이섬유소 섭취량이 유의하게 증가하였다. 4) 저이행군의 대사증후군 위험인자는 3.5개에서 2.8개, 고이행군의 대사증후군 위험인자는 3.3개에서 2.2개로 중재 후 대사증후군 위험인자가 유의하게 적었다. 본 연구 결과 대사증후군을 대상으로 한 식습관 및 생활습관 개선 중재프로그램에서 대상자들의 참여도와 실천정도가 높을수록 건강 개선에 더욱 바람직하였다. 이에 추후 연구에서는 중재 참여 대상자들의 참여율 및 실천지침 이행률을 높여 중재 프로그램의 효과를 극대화할 수 있는 체계적인 프로그램 개발이 이루어져야 할 것이다. This study examined how achievement of session goals contributes to outcomes of subjects after participation in a 12-week lifestyle intervention program in men with metabolic syndrome (MetS). Thirty office workers with MetS, aged 47.2 ± 6.6 years, participated in this study, from March to July, 2011. The intervention program included face-to-face counseling five times during the 12-week period. Counselors and subjects designed session goals for each round. The average of the goal achievement rate was calculated based on compliance for each round. The subjects were divided into three groups according to their tertiles of achievement rate: Low-compliance group (LC, < 59%), medium-compliance group (MC, 59-70%), and high-compliance group (HC, > 70%). Anthropometry, biochemical index, and nutrient intake were examined at baseline and at the end of the 12-week intervention program. After the intervention, diastolic blood pressure (DBP) showed a significant decrease in the LC group, and waist circumference (WC) showed a significant decrease in the MC group. Systolic blood pressure (SBP), DBP, and low-density lipoprotein cholesterol (LDL) showed a significant decrease in the HI group. Changes in SBP and DBP were significantly lower in the HC group than in the MC group (p < 0.05, p < 0.01). Changes in LDL were significantly lower in the HC group than in the MC group (p < 0.05). Results for intake of total energy, protein, fat, and sodium, as well as rates of carbohydrate and fat intake, showed a significant decrease in all participants (p < 0.05). The change in fiber was significantly higher in the HC group than in the MC group (p < 0.05). The change of fruit serving size showed a significant increase in the HC group (p < 0.01). The number of risk factors for MetS showed a significant decrease in the LC and HC groups (p < 0.05), however, no significant mean differences were observed among the three groups. In conclusion, participation in this intervention program resulted in positive effects on risk factors for MetS, nutrient intake, and dietary habits, especially in the High-compliance group. (Korean J Nutr 2013; 46(2): 156 ~ 165)