위험음주와 음주문제의 주관적 인식에 따른 한국어판 알코올사용장애 선별검사(AUDIT-K)와 변화준비도 검사(RCQ)의 차이

장옥진(Og-Jin Jang),최화경(Hwa-Kyung Choi,),이영렬(Young-Ryeol Lee),김세훈(Se-Hoon Kim) 한국중독정신의학회 2017 중독정신의학 Vol.21 No.2

Objective : This study was conducted to evaluate the differences in sub-scores for the AUDIT-K and Readiness to Change Questionnaires (RCQ) relative to hazardous drinking and subjective perceptions of alcohol problems. Methods : A total of 162 male participants were recruited and responded to the questionnaire. Subsequently, respondents were classified in the following groups depending on the presence of hazardous drinking and subjective perception of alcohol problems. HP group : Hazardous drinkers with subjective perception of alcohol problems. HD group : Hazardous drinkers with subjective denial of alcohol problems. NP group : Non-hazardous drinkers with subjective perception of alcohol problems.ND group : Non-hazardous drinkers with subjective denial of alcohol problems. Results : In the HP group (the highest AUDIT-K score), high consumption and dependence sub-scores and RCQ scores were observed. In the HD group (the second highest AUDIT-K scores), high consumption and dependence sub-scores were observed, but the RCQ score was low. In the NP group, AUDIT-K, consumption and dependence sub-scores were low but the highest harmful alcohol use sub-score and second highest RCQ score was observed. In the ND group, the lowest scores were observed for all mea-sures. Conclusion : Our findings suggest that there are differences in AUDIT-K and RCQ sub-scores associated with hazardous drinking and subjective perception of alcohol problems.

졸피뎀은 내성과 의존에서 안전한 약물인가?

장옥진(Og-Jin Jang),김호찬(Ho-Chan Kim) 한국중독정신의학회 2022 중독정신의학 Vol.26 No.1

Zolpidem is a short-acting non-benzodiazepine hypnotics and has a short elimination half-life that was introduced in the 1980s. It has an favorable and safe profile compared to short-acting benzodiazepines (BZD), so it was expected that the disadvantages of BZD, such as sedation the next day and daytime sleepiness, as well as dependence and withdrawal symptoms, could be overcome. However, there is a growing body of case reports on zolpidem abuse and dependence, as well as withdrawal syndrome and epileptic seizures related to zolpidem discontinuation. Many subsequent studies have revealed that increasing concentrations of zolpidem result in loss of receptor selectivity, and binds to other subunits of the GABA-A receptor, similar to benzodiazepine. Nevertheless, zolpidem is one of the most commonly prescribed hypnotics in Korea, and related abuse and dependence cases are increasing. Thus, it is necessary to understand the developing mechanism of abuse and dependence related zolpidem, and be prepared with strategies to detoxify or intervene in any related condition.

청소년 중독의 이해 : 마약중독

장옥진(Jang Og-Jin) 대한소아청소년정신의학회 2023 대한소아청소년정신의학회 학술대회논문집 Vol.2023 No.11

위험음주자 선별을 위한 한국판 알코올사용장애 선별검사(AUDIT-K), 알코올 소비 점수(AUDIT-C), 3번 문항(AUDIT3)의 유용성과 최적 절단값

우성목(Seong-Mok),장옥진(Og-Jin Jang),최화경(Hwa-Kyung Choi),이영렬(Young-Ryeol Lee) 한국중독정신의학회 2017 중독정신의학 Vol.21 No.2

Objective : This study was conducted to evaluate the availability and optimal cut off score for screening of hazardous drinking using AUDIT-K, AUDIT-C and AUDIT3. Methods : Participants in this study were recruited from an online site. Selected panel members participated in the survey through ‘Do It Survey’ (www.dooit.co.kr) February 10-15, 2016. A total 509 participants (males : 265, females : 244) were recruited. Subjects responded to the questionnaire about their drinking pattern, amount of alcohol consumption and AUDIT-K. The criteria for hazardous drinking were based on the NIAAA criteria. AUC of the ROC curve were calculated to evaluate availability and cut off scores for hazardous drinking of AUDIT-K, AUDIT-C and AUDIT3. Results : In AUDIT-K, suggestible cut off score for screening hazardous drinking based on the NIAAA criteria was 11 for males and 7 for females. AUDIT-C and AUDIT3 also available for detecting hazardous drinking. And suggestible cut off scores of AUDIT-C and AUDIT3 for hazardous drinking were 7 and 3 for males and 6 and 3 for females. Conclusion : Our findings suggest that AUDIT-C and AUDIT3 were available for detecting of hazardous drinking base on the NIAAA criteria. We also suggest that cut off scores for screening hazardous drinking.

생애초기스트레스와 불안정한 부모와의 유대관계가 의사결정유형과 음주동기에 미치는 영향

전재효(Jae-Hyo Jeon),장옥진(Og-Jin Jang),김기옥(Gi-Ok Kim),정영인(Young-In Chung) 한국중독정신의학회 2022 중독정신의학 Vol.26 No.1

Objective: The purpose of this study was to identify the effects of negative experience during childhood on drinking in adulthood. Methods: A total of 89 male subjects participated in the study and a survey was conducted July 1-July 31, 2019. Hierarchical regression analysis was conducted to confirm the relationships of early life stress (ELS) and insecure parental bonding (IPB) on decision-making style (DMS) and motivation for alcohol use (MA). Results: ELS and IPB had positive correlation with enhance and the coping subscore of MA. ELS and IPB had negative correlation with the rationality subscore of DMS and positive correlation with the intuition subscore of DMS. The regression analysis revealed ELS and IPB direct influence on enhance and coping among MA and rationality and intuition among DMS. These factors of DMS mediated the effects of ELS and IPB on enhance and coping of MA. Conclusion : This study found that early life stress and insecure parental bonding are related to irrationality and intuition among decision-making style and enhance and coping among motivation for alcohol use.

일 종합병원에서 정신분열병과 분열정동장애를 진단받은 환자에서 항정신병약물의 1차 선택약물의 비율 및 1년 유지율에 관한 연구

왕관수(Kuan-Shu Wang),김정기(Jeong-Gee Kim),조동환(Dong-Hwan Cho),제호준(Ho-Jun Je),서영익(Young-Ik Seo),장옥진(Og-Jin Jang),최성진(Seong-Jin Choi) 대한생물치료정신의학회 2008 생물치료정신의학 Vol.14 No.1

Objectives: This study was designed to evaluate prescription rate and indirectly the tolerability of antiosychotics using the maintenance rate for 1 year. The study was done in a situation where the patients who were diagnosed with either schizophrenia or schizoaffective disorder were given the antipsychotics and were looked into the prescription rate and the state of use of drugs at first regardless of kind of drugs. Methods: This was a retrospective, naturalistic study using the data from medical record conducted in both inpatients and outpatients from January 1st in 2002 and June 30th in 2004 with a diagnosis of schizophrenia and schizoaffective disorder as defined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Patients were evaluated at 3, 6, 9, and 12th months after the onset of medication for the first-drug prescription rate and maintenance rate. Results: In total, 105 patients were recruited, and 40 out of 105 were male and 65 out of 105 were female. The mean age was 34.71 years old. The number of patients with schizophrenia was 94 and that of schizoaffective disorder was 11. For the prescription rate of first drugs, of total risperidone was 56.2% ; likely, 25.7% for olanzapine ; 10.5% for haloperidol ; 4.8% for quetiapine ; and 2.9% for chlorpromazine. For 1-year maintenance rate, of total, haloperidol was 45.5% ; 33.3% for chlorpromazine ; 22.0% for risperidone ; 14.8% for olanzapine ; and 20.0% for quetiapine. Conclusion: Overall, atypical antipsychotics were far more prescribed than typical ones(86.7% and 13.3% for atypical and typical anti psychotics respectively). Although atypical antipsychotics were more prescribed than typical ones, the one-year maintenance rate was not higher than typical anti psychotics unlike our expectation that atypical antipsychotics would have better compliance and higher maintenance rate for 1 year under the circumstances with uncontrolled naturalistic conditions. There should be more statistical data available with larger sample size in the future.