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조피볼락 ( Sebastes schlegeli ) 의 성숙 출산기에 있어서 갑상선 및 성 스테로이드 호르몬의 혈중 변화
강덕영(Duk Young Kang),장영진(Young Jin Chang),손영창(Young Chang Sohn) 한국수산과학회 1998 한국수산과학회지 Vol.31 No.4
Changes in plasma levels of thyroid and sex steroid hormones were examined during maturation and parturition periods in rockfish (Sebastes schlegeli) cultured in net pens. Plasma L-thyroxine levels were 35.2±5.7ng/㎖(n=5; mean±sem) at vitellogenesis stage and then significantly decreased to 20.5±4.2ng/㎖ at parturition stage (P<0.05), and rapidly returned to high level, 44.9±7.2ng/㎖ at resting stage. Plasma 3,5,3`-triiodo-L-thyronine levels were 12.9±1.6ng/㎖ at vitellogenesis stage, but significantly decreased to 3.7±0.7ng/㎖ at ovulation stage (P<0.05) and increased to 52.9±7.0ng/㎖ at resting stage. Plasma estradiol-17β level showed the highest value(4.3±0.9ng/㎖) at vitellogenesis stage, but the level significantly decreased to 0.3±0.1ng/㎖ during parturition stage(P<0.05). In vitellogenesis and ovulation stages, plasma testosterone levels were 1.8±0.3ng/㎖ and 2.1±0.7ng/㎖, respectively, thereafter the level significantly decreased to 0.1±0.1ng/㎖ at parturition stage(P<0.05). These findings suggest thyroid hormones may have relation to maturation and parturition of mother rockfish.
양막세포에서 Interleukin - 1 Beta 에 의한 Cyclooxygenase - 2 의 발현 조절 기전
장영진(Young Jin Chang),박윤기(Yoon Ki Park),백석환(Suk Whan Baek),이영기(Young Ki Lee),이동혁(Dong Hyuk Lee),이현우(Hyun Woo Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.8
N/A objective : To determine of the regulation of cyclooxygenase-2 (COX-2) expression by Interleukin-1β in WISH cells. Methods : Amnion WISH cells were incubated in media containing increasing concentrations of IL-1β or with various inhibitors. Increased COX-2 expression was determined by Western blot analysis with anti-COX-2 antibody. Concomitant measurements of culture media PGE2 were made by an enzyme immunoassay. Results : The COX-2 and prostaglandin E2 production induced by IL-1β increased in a dose- and time-dependent manner. One of the regulating factors that induced COX-2 by IL-1β was protein kinase C (PKC). PKC inhibitor, Ro 31-8220 was pretreated and continued treating by IL-1β. Then, PKC inhibitor completely blocked COX-2 protein induction by IL-1β. In contrast, COX-2 induction by IL-1β after pretreating PKC stimulator, phobol 12-myristate 13-acetate was potentiated with synergism. Another factor in controlling COX-2 protein induction was identified as phosphatidylinositol 3-kinase (PI 3K). COX-2 protein induction by IL-1β after pretreating PI 3K inhibitors, wortmannin and LY294002 strongly increased. This kind of result reflected that PI 3K act as negative regulator. COX-2 induction by IL-1β was known to be regulated in not only transcription step, but also translation step after performing experiment of actinomycin and cycloheximide treatment. Conclusion : COX-2 protein and prostaglandin E2 production induced by IL-1β were controlled by many factors in amnion cell. Among those factors, PKC and PI 3K have an important role, but their control mechanism act as positive and negative, respectively.
3,5,3'-triiodo-L-thyronine(T3) 모체주사에 의한 조피볼락 ( Sebastes schlegeli ) 혈중 , 알 및 난황난 자어의 갑상선 호르몬 농도 변화
장영진(Young Jin Chang),강덕영(Duk Young Kang) 한국수산과학회 1998 한국수산과학회지 Vol.31 No.5
The changes of thyroid hormone levels in plasma, eggs and yolk-sac larvae in female rockfish (Sebastes schlegeli) were examined after maternal injection of 3,5,3`-triiodo-L-thyronine (T₃) with a dose of 20 ㎎/㎏ fish wt. There were no diffrences of L-thyroxine (T₄) level in maternal plasma and yolk-sac larvae between T₃ injection and vehicle-injected control. The sigaificant decrease of T, level was found in eggs from the T₃ injected mother fish compared with that of control. T₃ levels in maternal plasma, eggs, and yolk-sac larvae were significantly elevated by T₃ injection. Therefore T₄ and T₃ in maternal circulation may be transferred into oocytes and subsequently into the yolk-sac larvae. These findings suggest that thyroid hormones may play some roles on physiological metabolism during early larval development of rockfish.