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양막세포에서 Interleukin - 1 Beta 에 의한 Cyclooxygenase - 2 의 발현 조절 기전
장영진(Young Jin Chang),박윤기(Yoon Ki Park),백석환(Suk Whan Baek),이영기(Young Ki Lee),이동혁(Dong Hyuk Lee),이현우(Hyun Woo Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.8
objective : To determine of the regulation of cyclooxygenase-2 (COX-2) expression by Interleukin-1β in WISH cells. Methods : Amnion WISH cells were incubated in media containing increasing concentrations of IL-1β or with various inhibitors. Increased COX-2 expression was determined by Western blot analysis with anti-COX-2 antibody. Concomitant measurements of culture media PGE2 were made by an enzyme immunoassay. Results : The COX-2 and prostaglandin E2 production induced by IL-1β increased in a dose- and time-dependent manner. One of the regulating factors that induced COX-2 by IL-1β was protein kinase C (PKC). PKC inhibitor, Ro 31-8220 was pretreated and continued treating by IL-1β. Then, PKC inhibitor completely blocked COX-2 protein induction by IL-1β. In contrast, COX-2 induction by IL-1β after pretreating PKC stimulator, phobol 12-myristate 13-acetate was potentiated with synergism. Another factor in controlling COX-2 protein induction was identified as phosphatidylinositol 3-kinase (PI 3K). COX-2 protein induction by IL-1β after pretreating PI 3K inhibitors, wortmannin and LY294002 strongly increased. This kind of result reflected that PI 3K act as negative regulator. COX-2 induction by IL-1β was known to be regulated in not only transcription step, but also translation step after performing experiment of actinomycin and cycloheximide treatment. Conclusion : COX-2 protein and prostaglandin E2 production induced by IL-1β were controlled by many factors in amnion cell. Among those factors, PKC and PI 3K have an important role, but their control mechanism act as positive and negative, respectively.
金銀花(Lonicerae Flos) Ethyl Acetate 分割의 過酸化脂質生成抑制에 關한 硏究
鄭圭燦,朴貞玉,裵基哲,權東烈,白錫煥 영남대학교 자원문제연구소 1990 資源問題硏究 Vol.9 No.-
The inhibitory effects of Lonicerae Flos' fractions ( benzene, CHCl₃, EtOAc and MeOH fraction. respectlvely ) on microsomal lipid peroxidation were comparatively studied and furthermore each components of EtOAc fraction has been examined. It is found that G component of EtOAc fraction inhibited most strongly for lipid peroxidatlon. Among the EtOAc fractions, G component was identified to be luteolin. Also, EtOAc fraction showed particularly strong increment against superoxide dismutase activlty