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문우성,이동근,오강열,장성강,최호열,김상호 의과학연구소 1992 全北醫大論文集 Vol.16 No.3
A 25 year-old male with angioimmunoblastic tyrnphadenophthy(AILD) was reported with review of literatures. Clinically, he complained of generaized tyrnphadenopathy, fever, cutaneous rash, and splenomegaly and serum protein electroporesis revealed polyclonal gammopathy. Histologic finding of excised Iymph node were characterized by 1) loss of nodal architecture and infiltration of immunoblasts, plasma cells, Iymphocytes and eosinophils, 2) prominent proliferation of arborizing blood vessels, and 3) deposit of PAS-positive amorphous materials in the interstitium. After 3 weeks of prednisolon therapy, remarkable improvement of his clinical was occurred and alive 20 months after diagnosis.
Ehanol에 依하여 損傷된 胃粘膜 上皮의 回復에 關한 實驗的 硏究
최삼임,이혜수,고범권,장성강,강명재,조남표,조성남,김상호 의과학연구소 1992 全北醫大論文集 Vol.16 No.2
This study aimed to investigate muoosal damage and restitution in the rat stomach after absolute ethanol instillation. Four me. of absolute ethanol was instilled to stomach and gastric mucosa was exposed to it for 30 and 45second , and then examined at immediately, 10 minute, 30 minutes, 60 minutes and 6 hours. Morphological studies of gastric tissue were performed by means of epon-toluidine blue section, H&E, and periodic acid Schiff(pAS) stains. The results were as follows. 1. Immediately after exposure to absolute ethanol far 30· seconds(time 0), surface mucous cells and the cells lining the gastric pits were damaged and exfoliated, but the gastric gland cells were not damaged. 2. Immediately after exposure to absolute ethanol for 45 seoends(time 0), superficial epithelium was necrotic and cellular damage was evident in the gastric glands beneath the damaged surface and gastric pits. Some inflammatory reaction was also noted. 3. Hyperemia and hemorrhage in the gastric mucosa were evident in almost all experimental groups 4. Epithelial restitution was begun to observe at 30 minutes in both 30 and 45 seconds-exposure groups, and almost completely restituted at 60 minutes after ethanol exposure. Surface mucous cells in restituted area were somewhat different from normal mucous cells morphologically. 5. According to damage of surface mucous cells, cytoplasmic PAS-positive granules were markedly decreased, but the PAS-positivity was also restored with restitution of mucous cells(even if weaker reaction than in normal mucous cell). It is thought that absolute ethanol-induced mocosal damage is striking even if the exposure time is brief, and epithelial restitution is achieved for 30 or 60 minutes after ethanol exposure. The mechanism of epithelial restitution might be resulting from migration of undamaged epithelial cells.