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Acinetobacter sp. 로부터 분비된 성장억제물질이 수종의 구강세균의 성장에 미치는 효과
조철호,민윤기,장기완 대한구강보건학회 1999 大韓口腔保健學會誌 Vol.23 No.1
The production of growth inhibitory substances in the bacterial world is ubiquitous. Growth inhibitory substances inhibit the growth of other strains of bacteria. They are proteins which are often complexed with lipids and/or carbohydrates. The purpose of this study is to investigate in vitro antibacterial effect of Acinetobacter sp. on some oral bacteria. A growth inhibitory substances from Acinetobacter sp. was isolated and its properties were characterized in order to obtain possible antibacterial agents. We purified partially and examined the effect of growth inhibitory substances on the growth of some oral bacteria. Assays for inhibitory activity were studied by a diffusion method. The inhibitory activity was determined on the basis of the diameter of zones of growth inhibition. It had potent antibacterial effects, in vitro, against Capnocytophaga and Streptococcus species. The results obtained were as follows. 1. The microbial isolate with growth inhibitory activity from soil was classified into Acinetobacter sp.. 2. Acinetobacter sp. was resistant to its growth inhibitory substance but C. ochracea ATCC 27872, C. sputigena ATCC 33612, C. gingivalis ATCC 33624, S. mutans KCTC 3065, S. sobrinus KCTC 3308, and S. cricetus KCTC 3292 strains were sensitive to it. 3. Growth inhibitory substance of Acinetobacter sp. was secreted into culture media. This substance was stable at 40℃ for 3 hours, but completely inactivated at 55℃ for 30 minute. It was sensitive to trypsin and proteinase K, which suggest proteinous substance.