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      • 에탄올에 의한 Epidermal Growth Factor 수용체 결합의 변화

        임희경,여의주 제주대학교 생명과학연구소 2000 제주생명과학연구 Vol.3 No.-

        Ethanol interferes with the proliferation of several cell lines in vitro and in vivo. The anti-proliferative effects of ethanol have been suggested to contribute to the pathogeneses and progression of alcoholic diseases. To define the cellular and molecular mechanisms in the anti-proliferative actions of ethanol, the growth factor- induced signaling processes have been studied in various cells. Ethanol effect is different depending on whether its action is acute or chronic, the type of growth factors, and the concentration of both ethanol itself and the growth factor(s). Previously, we have reported that the growth of Swiss 3T3 cells was inhibited by ethanol in a concentration-dependent manner. A disruption of cellular proliferation might be due to an inhibitory effect of ethanol on growth factor- mediated cellular signaling systems for the mitogenic function. An ㅑnitial step of epidermal growth factor (EGF)-signaling events, tyrosine autophosphorylation of the growth factor receptors, was especially prevented by ethanol in the cell line. Since the receptor autophosphorylation is triggered by initial binding of EGF and its receptor, we further investigated the ethanol effect on [125I] EGF- binding to ㅑts receptor. Scatchard plot analysis demonstrated that [125I] EGF-binding to high-affinity states of the EGF receptor was decreased by 60%. This finding could explain the modified responses to this growth factor in Swiss 3T3 cells treated with sub- lethal concentrations of ethanol.

      • 효모추출물의 사료 첨가가 성장과 사이토카인의 발현 변화에 미치는 영향

        임희경,Baatartsogt. O,서상원,김희철,이종석,안광철,김상호,김지혁,장병귀,이준헌,이상범,최강덕 한국가금학회 2007 한국가금학회 정기총회 및 학술발표회 Vol.24 No.-

        The experiment was conducted to compare the effects of supplements of yeast extract on growth and immune responses of chicks fed diets. Total 120 of chicks were employed in this experiment to study the effects of feeding of yeast extract on the performance and expression of cytokine. They were randomly allocated to tree dietary treatments; control, antibiotic group(ABG), yeast extract group(YEG). Growth characteristics by feeding yeast extract were significantly difference on body weight. Feed intake contained yeast extract was 69g daily and showed higher than other group. To evaluate the immune response effects of the feeding yeast extract, the expression patterns of IL-2, IL-6, IFN-γ in spleen cell were studied by RT-PCR. The higher expression levels of IL-2, IL-6 and IFN-γ transcripts after Salmonella gallinarum infection were observed in the group with yeast extract. From the result of this experiment, it could be concluded that feeding yeast extract improves the laying performance growth and immune response activation.

      • KCI등재후보

        설명가능한 인공지능(explainable AI, XAI)의 필요성과 연구동향

        임희경,김승언 조선대학교 IT연구소 2022 정보기술융합공학논문지 Vol.12 No.1

        Recently, in the field of artificial intelligence, with the development of machine learning technologies such as deep learning, its utility is increasing in various application fields. Machine learning technology, which learns a model based on a large number of learning data and applies it to new data, has brought great performance improvement in various fields of artificial intelligence, such as image classification, natural language processing, time series data analysis and prediction. Artificial intelligence is now deeply involved in our lives, including autonomous driving, medical surgery assistance, and factory automation. As the number of services provided by artificial intelligence systems increases, it is a very important issue to determine how reliable the decisions made by artificial intelligence systems and recommendations for those decisions can be. This paper introduces the concept of explainable artificial intelligence that explains the results and processes presented by artificial intelligence in a way that humans can understand, and intends to share the current domestic and foreign research trends.

      • KCI등재

        고학력 지식인 탈북자가 경험하는 심리사회적 현상

        임희경,한재희 한국상담학회 2017 상담학연구 Vol.18 No.4

        This paper is rooted in the purpose of gaining a deeper understanding of the meaning and significance of the psychosocial phenomena experienced by highly educated North Korean defectors. The seven participants who agreed to this study have been experts in various fields since entering Korea after having graduated from a four-year university or further education in North Korea. In two rounds of in-depth interviews and the accumulated data were analyzed through phenomenological qualitative method. The results of the research were categorized into ‘motivation of defectors of highly educated intellectuals’, ‘psychosocial characteristics of highly educated intellectual defectors’ and the ‘psychological integration of highly educated intellectuals defectors of North and South Korean society experience. Firstly, First, the participants’ motivation to escape was revealed by the experience of conflict between the ruling ideology and reality, and the choice of defection for survival. Secondly, the psychological phenomena experienced by the participants in the Korean society include anxiety about the uncertain environment after asylum, shielding from guilt through social activities, social exclusion in their respective specialized fields, alienation in social settings, instability from the unique environment of a divided nation, recognizing their limitations while pursuing the ideal society, acceptance of the surrounding environment through self-acceptance, and self-verification through the implementation of knowledge. Thirdly, the psychological integration of participants’ experiences in the two Koreas was revealed by the identity established in a democratic environment, the dream of unification beyond individual gains, and the wish of bridge role of inter - Korean integration. In the meantime, due to social prejudice and limited information, the stories and experiences of North Korean privileged have not been well known into South Korean society. This study is meaningful intending to provide the basic data related to counseling area and psychosocial support which need a deep understanding of the individual characteristics of North Korean refugees, the differences in the motives of defection and the social status of defectors by understanding and revealing the psychological phenomena, the social structural characteristics that the participants experienced in the social context and the inter-relationship between both of them. 본 연구는 고학력 지식인 탈북자가 경험하는 심리사회적 현상의 본질과 의미를 심층적으로 이해하려는 목적에서 출발했다. 본 연구에 동의한 7명의 참여자들은 북한에서 4년제 대학을 졸업하거나 혹은 그 이상의 교육을 받은 후 북한의 전문 분야에서 경력을 갖춘 자들로 한국에 입국한 이후부터 현재까지 다양한 영역에서 전문가로 활동하고 있다. 2차에 거쳐 진행된 심층인터뷰를 통하여 수집된 자료는 현상학적 질적 연구방법으로 분석했으며, 연구결과는 <고학력 지식인의 탈북동기>, <고학력 지식인 탈북자의 심리사회적 특성>, <고학력 지식인 탈북자의 남북한 사회 경험의 심리적 통합>으로 구분하여 제시했다. 첫째, 본 연구 참여자들의 탈북 동기는 지배이념과 현실 간의 갈등 경험, 생존을 위한 탈북선택으로 드러났다. 둘째, 참여자들이 한국사회에서 경험한 심리적 현상은 망명 후 불확실한 환경에 대한 불안감, 사회활동을 통한 죄책감 방어, 전문영역에서 경험한 사회적 배제, 사회적 관계에서 경험한 소외감, 분단국가라는 환경으로 인한 불안정감, 이상적 세계 추구에 대한 자기한계, 자기 수용을 통한 환경의 수용, 지식의 실천을 통해 확인한 존재감으로 나타났다. 셋째, 참여자들의 남북한 사회 경험의 심리적 통합은 민주적 환경에서 확립한 정체성, 개인적 이익을 초월한 통일의 꿈, 남북통합의 교량 역할 소망으로 나타났다. 그동안 한국사회에서는 북한의 특권계층에 대한 사회적 편견과 제한된 정보로 인해 이들의 삶의 경험과 그 안에 담겨져 있는 이야기는 잘 알려지지 않았다. 본 연구는 참여자들이 소속된 사회적 맥락 안에서 이들이 경험한 심리적 현상과 사회구조적 특징, 그리고 이 둘 간의 상호연관성을 이해하고 드러냄으로써 탈북동기와 탈북계층의 차이, 탈북자들의 개별 특성에 대한 깊은 이해를 필요로 하는 상담분야 및 심리사회적 지원과 관련된 기초자료를 제공하는데 의의가 있다.

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