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Inhibitory Effects of KM1701 on Airway Cell Infiltration in OVA-Induced Mouse Model
임순민,최한석,김상백,김예진,강기성,신명숙,김경준,황귀서,구본암 대한한방안이비인후피부과학회 2019 한방안이비인후피부과학회지 Vol.32 No.2
Objectives : The objective of present study is to evaluate anti-inflammatory and anti-allergic effects of Perilla(Perilla frutescens; Labiatae, PF), the roots of Peucedanum praeruptorum(PP) and the root of Scutellaria baicalensis(SB) in vitro and anti-asthmatic effects of mixture of PF, PP and SB(PS) on ovalbumin (OVA)-induced asthma in BALB/c mice. Methods : Anti-inflammatory and anti-allergic effects were observed on the lipopolysaccharide(LPS) treated RAW 264.7 cells through Nitric Oxide(NO) production and RBL-2H3 cells through β-hexosaminidase. Anti-asthmatic effects were observed on the number of inflammatory cells in bronchoalveolar lavage fluid(BALF) and the level of IgE in serum on OVA-induced BALB/c mice. Results : The treatment of PF, PP and SB(12.5, 25, 50, 100㎍/㎖) resulted in a significant inhibition of NO production in RAW 264.7 cells and mast cell degranulation in RBL-2H3 cells. Oral administration of PS(400㎎/㎏/day) resulted in a significant reduction in the numbers of eosinophils in BALF and level of IgE in serum. Conclusion : The oral administration of PS is effective in ameliorating the eosinophilic infiltration in vivo and thus can be a good therapeutic candidate for allergic asthma.
최재석,송준태,장호성,최민재,심동민,임순민,임훈희,정연식,오지훈 대한금속·재료학회 2017 ELECTRONIC MATERIALS LETTERS Vol.13 No.1
Photoelectrochemical (PEC) water splitting has emerged as a potential pathwayto produce sustainable and renewable chemical fuels. Here, we present a highlyactive Cu2O/TiO2 photocathode for H2 production by enhancing the interfacialband-edge energetics of the TiO2 layer, which is realized by controlling thefixed charge density of the TiO2 protection layer. The band-edge engineeredCu2O/TiO2 (where TiO2 was grown at 80 °C via atomic layer deposition)enhances the photocurrent density up to −2.04 mA/cm2 at 0 V vs. RHE under 1sun illumination, corresponding to about a 1,200% enhancement compared tothe photocurrent density of the photocathode protected with TiO2 grown at150 °C. Moreover, band-edge engineering of the TiO2 protection layer preventselectron accumulation at the TiO2 layer and enhances both the Faradayefficiency and the stability for hydrogen production during the PEC waterreduction reaction. This facile control over the TiO2/electrolyte interface willalso provide new insight for designing highly efficient and stable protectionlayers for various other photoelectrodes such as Si, InP, and GaAs.