http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
임동술,유승조,이숙연,Yim, Dong-Sool,Yoo, Seung-Jo,Lee, Sook-Yeon 한국생약학회 1997 생약학회지 Vol.28 No.4
Verbascoside has inhibition activity on carrageenan induced edema in rat paw, enhancement of bile juice secretion, and hepatoprotective activity. The hepatoprotective functions were improved on serumtransaminase activities (s-GPT and s-GOT), liver weight, and even sleeping time in mice treated with verbascoside. In addtion, the mice toxicated with carbon tetrachloride are signiflcantly recovered by the administration of verbascoside. This is the first report shown their biological activity of verbascoside.
임동술(Dong Sul Im),유승조(Sung Cho You),지형준(Hyung Joon Chi) 한국생약학회 1985 생약학회지 Vol.16 No.1
출(朮) Atractylodis Rhizoma은 국화과에 속하는 다년생 초본으로 식물명은삽주(Atracylodes japonia Koidzumi)이고 약으로 사용될 때는 백출(白朮)과 백출(蒼朮)로 나눈다. 창출의 약리 작용으로는 이뇨, 발한, 건위, 정장등이 알려졌다. Atractylodes japonica의 화학성분은 Acetaldhyde, z-Furaldehyde, atractylon, 5α H. 10β-selina-4(14) . 7(11)-dien-8-one과 polyacetyleneCompound인 diacetylatractylodiol등이 분리 보고되었다. 저자등은 한국산과 일본산의 창출성분을 비교하기 위해서 한국산 창출의 정유성분을 연구하였다. 추출재료인 창출은 서울에서 구입하여 사용하였고 시판품을 비교하기 위해서 부산, 광주, 제주에서 구입하고 채집품도 비교하기 위해 백봉에서 채집하였다. 재료들을 수증기 증류법을 사용하여 얻은 유상물질을 n-Hexane으로 수회 분획하여 n-Hexane Ex를 얻어 Column chromatography를 하였다. 이미 보고된 atractylon, 5α H. 10β-selina-4. (14). 7(11)-dine-8-one, hydroxyatractylon을 단리 확인하였고 polyacetylen compound인 diacetylatractylodiol보다 분자량이 14 더 많은 아직까지 분리, 보고되지 않은 새로운 물질인 1,4-diacetoxyltetradeca-6,12-dine-8,10-diyne으로 추정되는 물질을 단리 확인하였다.
임동술(Dong sool Yim),유승조(Seung jo Yoo),이숙연(Sook youn Lee) 한국생약학회 1995 생약학회지 Vol.26 No.2
The plant of Pedicularis resupinata L.var. oppositifolia (Scrophulariaceae) appeared to be used for the treatment of rheumatoid arthritis, malignant abscess (tumor), urolith, and diuretics in oriental medicinal literatures. Three different compounds were isolated from the aerial part of the plant and characterized by the spectroscopic (UV, IR, NMR, MS) analysis. These compounds were acteoside (compound I), suavissmoside R1 (compound II), and D-mannitol (compound III).
임동술(Dong Sool Yim),유승조(Seung Cho Yu),지형준(Hyung-Joon Chi) 한국생약학회 1988 생약학회지 Vol.19 No.4
From the rhizome of Atractylodes japonica Koidzumi (Compositae) which is the original plant of oriental medicine Cang-Zhu, four essential oil compounds were isolated. Three of them were identified as atractylon, hydroxyatrac tylon and 5αH, 10β-selina-4(14), 7(11)-dine-8-one, which were already known as the constitutents of Atractylodes Rhixoma. The fourth is a novel polyacetylene type compound, and the structure is postulated as 1, 4-diacetoxytetradeca-6, 12-diene-8, 10-diyne by the spectral data.
미강(Rice Bran) 추출물의 HL-60 백혈병 세포 Apoptosis 유도 효과
김은지,임동술,문정선,강정일,이영기,고영상,유은숙,강희경 한국생약학회 2013 생약학회지 Vol.44 No.3
In this study, we investigated the anticancer effect of rice bran extract in HL-60 human promyelocytic leukemia cells. The extract of rice bran inhibited the proliferation of HL-60 cells. When treated with the rice bran extract, we could observe the apoptotic characteristics such as apoptotic bodies and the increase of sub-G1 hypodiploid cell population, increase of Bax level, decrease of Bcl-2 expression, cleavage of procaspase-3, cleavage of procaspase-9 and cleavage of poly(ADPribose)polymerase(PARP) in HL-60 cells. Furthermore, the apoptosis induction of HL-60 cells treated with the rice bran extract was also accompanied by the inactivation of mitogen-activated protein kinases (MAPK) such as ERK1/2 MAPK and p38MAPK. In addition, the rice bran extract induced the down-regulation of c-myc. These data suggested that the rice bran extract could induce the apoptosis via the inactivation of ERK1/2 MAPK and p38 MAPK, and the down-regulation of c-myc in HL-60 acute pomyelocytic leukemia cells. The results support that the rice bran extract might have potential for the treatment of acute promyelocytic leukemia.
백지(Angelica dahurica) 추출물의 Helicobacter pylori 에 대한 항균력 및 H. pylori로 유도한 염증반응에 대한 항염 효과
최민경,임동술,최성숙 한국생약학회 2018 생약학회지 Vol.49 No.3
The aim of this study was to evaluate the anti-helicobacter activity and anti-inflammatory activity of Angelica dahurica (AD). The minimum inhibitory concentration(MIC) of AD against Helicobacter pylori(H. pylori), expression of the H. pylori cagA gene in the presence of AD was determined. Inhibition of H. pylori urease by AD, inhibition of nitric oxide (NO) production in AGS cells was measured. IL-8 mRNA expression in AGS cells which were infected with H. pylori and IL-8 level was measured. The MIC of MeOH Ex. of AD was 250 μg/mL and the expression of cagA gene was decreased about 88% in the presence of AD. The activity of H. pylori urease was inhibited 70% by AD. mRNA expression of IL-8 and the production of NO and IL-8 were significantly decreased in the presence of AD. In conclusion, AD showed anti-Helicobacter activity and has potent anti-inflammatory effect on H. pylori-induced inflammation in human gastric epithelial AGS cells.
가미청간탕(加味淸肝湯)이 Rat의 알코성 지방간에 미치는 영향
정성현,임동술,이숙연 한국생약학회 2004 생약학회지 Vol.35 No.3
- The Korean folk medicine “Jin Hae Cho Ip” has been used as a remedy for neuralgia and as an invigorating drug after a childbirth, etc in Korea. With regard to the botanical origin of “Jin Hae Cho Ip”, several species of Potentilla (Rosaceae) has been refered, but no pharmacognostical study has yet been performed in this regard. To clarify the botanical origin of the “Jin Hae Cho Ip”, the morphological and anatomical characteristics of the leaflets and petioles of Potentilla and Sibbaldia species growing in Korea, such as P. chinensis, P. cryptotaeniae, P. dickinsii, P. discolor, P. fragarioides var. major, P. freyniana, P. kleiniana, P. matsumurae, P. paradoxa, and S. procumbens, were compared. As a result, it was found that “Jin Hae Cho Ip” was composed of the leaves of P. chinensis and P. discolor.