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이홍탁,양태호,윤태영,장승호 대한의진균학회 1999 대한의진균학회지 Vol.4 No.1
Mucormycosis is an invasive fungal infection, caused by members of the order Mucorales, that usually occurs in immunocompromised individuals. It manifests itself in a variety of ways and rarely may be confined to the cutaneous tissues. We report a case of primary cutaneous mucormycosis associated with longstanding diabetes mellitus and liver cirrhosis. A 53-year-old woman was presented because of cutaneous discoloration and bullae on the both lower extremities. Cutaneous lesions consisted of necrotic blackish discoloration with bullae and ill-defined margins with extending nature. A biopsy specimen from the cutaneous lesion revealed large, broad, nonseptate hyphae branched at right angles. Our patient was successfully treated with intravenous administration of amphotericin B and surgical debridement of necrotic tissue. [Kor J Med Mycol 4(1): 75∼78]
이홍탁,윤태영,장승호 ( Hong Tak Lee,Tae Young Yoon,Seung Ho Chang ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.2
Background: The high level of susceptibility of patients with liver cirrhosis(LC) to septicemic infection is thought to be due to decreased reticuloendothelial function and irnpairment of several components of cell mediated and humoral immunity. It is well known that LC may cause many characteristic skin changes including jaundice, spider angioma, palmar erythema, xanthelasrna and nail changes such as clubbing and white nails. Objective and Methods : During a 7 month period frorn April to October 1995, 100 patients who had been diagnosed as having LC were evaluated for the duration of their LC, the associated diseases they had apart from LC and various skin manifestations. Also, we performed the tuberculin test in 20 patients with LC and evaluated the correlation of the tuberculin test with severity of LC divided into 3 groups according to the Childs classification. Results : The results are summarized as follows ; 1. The most frequent duration of LC was under 5 years(74%). 2. The most common associated disease of patients with LC was upper GI bleeding including esophageal varix(24 cases). Also, diabetes mellitus(13 cases) and hepatic coma(11 cases) were observed. 3. Jaundice(82 cases) was the most frequent skin rnanifestation of patients with LC. In addition, vascular changes(81 cases) and various nail changes(69 cases) were observed. Onychomychosis was the most common nail change of patients with LC. 4. 60% of the patients who were given the tuberculin test showed anergy, and the frequency of anergy increased in proport on to the severity of LC. However, it was not significant statistically(p> 0.05 ). Conclusions : Some of the skin manifestations help in the diagnosis of LC. Also, increased frequency of tuberculin test anergy in proportion to the severity of LC is thought to be related to decreased cell mediated immunity, although statistically it is not significant. (Kor J Dermatol 1997;35(2): 228-233)
이홍탁,장승호,윤태영 ( Hong Tak Lee,Seung Ho Chang,Tae Young Yoon ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.1
Infantile myofibromatosis is an uncornmon, benign, self-limiting, localized or generalized process, probably of hamartomatous origin, which consists to a large degree of cells having the characteristics of myofibroblasts and sometimes of pericytes. Both solitary and multicentric forms occur. Most lesions are present at birth or in early infancy, and some are familial in origin. A female newborn presented with a firm, round, red colored, 3 x 3 cm sized tumor with central necrosis on the left chest. Histological examination revealed well-circumscribed nodules consisting of short bundles of plump, spindle shaped cells displaying staining characteristics intermediate between fibroblasts and smooth muscle cells. The tumor was immunoreactive for actin but did not stain for desmin. A Follow-up examination at the age of 3 months revealed a moderate degree of spontaneous regressior of the lesion. (Kor J Dermatol 1997;35(1): 182~186)