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철갑소이탄에 의한 전투시스템 내 적재포탄의 순간화재에 관한 전산해석
이승철(Lee, Seung-Cheol),전우철(Jeon, U-Cheol),이해평(Lee, Hae-Pyeong),이헌주(Lee, Heon-Ju) 한국화재소방학회 2013 한국화재소방학회 학술대회 논문집 Vol.2013 No.추계
본 연구에서는 철갑소이탄이 장갑을 관통한 후 전투시스템 내의 적재포탄(고폭탄 또는 추진제)에 피탄되었을 때 순간화재 발생확률에 대해 전산해석을 수행하였다. 장갑은 RHA 재질로 설정하였고, 장갑 두께를 5~30 mm까지 5 mm씩 증가시키며 전산해석을 실시하였다. 고폭탄은 COMPB, TNT, PBX가 사용되었으며 추진제는 ANB가 사용되었다. 본 해석은 Autodyn 프로그램을 사용하였으며, 순간화재 발생 여부를 해석하기 위해 Lee-Tarver ignition and growth model을 사용하였다. 해석 결과, 철갑소이탄이 고폭탄 TNT와 PBX에 피탄되었을 때, 순간화재 발생확률이 모두 100%를 나타내었으며, 고폭탄 COMPB의 경우, 0.8~0.08%로 나타났다. 추진제 ANB의 순간화재 발생확률은 3.8~3.6%로 나타났다.
이헌주(Heon Ju Lee),이재련(Jae Lyun Lee),이재춘(Jae Chun Lee),이은정(Eun Jung Lee),김기범(Ki Beom Kim),임상우(Sang Woo Lim),이동준(Dong Jun Lee),전경진(Kyeoung Jin Jeon),조영복(Young Bog Cho),도갑석(Gab Suk Doh),서정일(Jeong Ill Suh) 대한내과학회 1995 대한내과학회지 Vol.49 No.1
N/A Objectives: 80-90% of the cases of hepatocellular carcinoma(HCC) are associated with cirrhosis. Hepatitis B virus(HBV) is known as a major etiologic factor of HCC and about 10% of Koreans are HBV carriers. And the prevalence of HCC is high in Korea. Early detection of HCC is important for the better treatment especially in the patients with cirrhosis who usually have the decreased functional hepatic reserve. Risk factors for the hepatocellular carcinoma in the korean patients with cirrhosis were evaluated. Methods: Risk factors for hepatocellular carcinogenisis such as age, sex, ascites, alcohol, HBsAg, anti-HCV, AFP, ICG R(15) and risk score were investigated among the 176 patients with cirrhosis and HCC(group I) and 72 patients with cirrhosis(group II) and compared between the two groups. Results: 1) No age difference was noted between group I and group II. 2) Male to female sex ratio were 5.7: 1 and 2.4: 1 for group I and II in each(p<0.01) and the frequency of HCC among cirrhosis was higher in male than female sex(p<0.01). 3) Both HBsAg and anti-HCV positivity were significantly higher in group I than in group II (p<0.01 and p<0.05 respectively). 4) The frequencies of Child-Pugh A, elevated AFP, elevated ICG R(15) and the frequency of super-high risk patient were higher in group I than in group II(p<0.01). 5) The frequency of alcoholic patients was significantly higher in group II than in group I (p<0.05) but no difference was noted between HBsAg positive group I and group II patients. 6) The frequency of abnormal AST with the level of below 100IU was not significantly different between group I and group II. 7) The frequency of the patients with ascites was higher in group II than in group I (p<0.01). Conclusion: Risk factors for hepatocellular carcinogenesis in korean patients with cirrhosis are male, Child-Pugh A, HBsAg positivity, anti-HCV positivity, absence of ascites, higher AFP, lower ICG R15 and higher platelet count.
이헌주(Heon Ju Lee),이현우(Hyun Woo Lee),윤봉영(Bong Young Yoon),김종명(Jong Myung Kim),김정회(Jung Hee Kim),곽철승(Chul Sung Kwak) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.2
N/A Evaulation of serum bile acids has been used for prediction of abnormal serum liver profile in the world. But recently many reported that bile acids in a random sample of urine (URNBA), corrected for urine flow with creatinine, have high diagnostic value when compared with serum bile acid and routine serum liver tests. We analyzed URNBA as a predictor of liver abnormality in 27 subjects of various liver disease and 8 normal subjects and compared with the results of serum bile acids and routine serum liver profile. In the patients, the rates of abnormal elevation of URNBA and serum bile acid were 85.2% (23/27) and 74.1% (20/27), respectively. URNBA/creatinine in the random sample of urine revelaed the highest reliability that reflects the presence of liver disease. So we think that urine can be used to predict liver diasese with an accurary that equals or exceeds the serum bile acid and the routine liver tests.
혈청 anti - HCV 양성자의 역학 및 가족내 감염과 HBV 표지자에 관한 조사
이헌주(Heon Ju Lee),강호정(Ho Jung Kang),김기덕(Kee Duck Kim),박찬원(Chan Won Park),윤현대(Hyun Dae Yoon),전진종(Jin Chong Chun),최교원(Kyo Won Choi),최희진(Hee Jin Choi) 대한내과학회 1992 대한내과학회지 Vol.43 No.6
N/A Background: Transfusion is a well-known source of hepatitis C virus (HCV) infection but over half of the hepatitis C patients do not have any suspicious source of infection. Epidemiological survey and serological test for HBV marks were done among anti-HCV positive chronic liver disease patient and their family members. Method: 74 cases of anti-HCV postitive chronic liver disease patients were evaluated for the evident source of HCV infection and 188 of their family members were consulted for the infection of HCV. To compare the mode of HBV infection with HCV, serum HBsAg, anti-HBc and anti-HBs were checked in 43 of HBsAg positive chronic liver disease patients, 190 of their family members, 64 anti-HCV postive chronic liver disease patients and 239 of normal control persons. Results: 35cases (47.3%) of 74 anti-HCV positive chronic liver disease patients had no suspicious source of infection and only 16 cases (21.6%) had the history of past transfusion. No family members except 3 (one infant, one IV drug abuser and one wife) in 3 families among 74 families were anti-HCV positive. 29 of 43 (67. 4%) families of HBsAg positive chronic liver disease patients had at least one of HBsAg positive member. Characteristically, HBsAg was positive in almost all cases of offsprings born to mothers of HBsAg and HBeAg positive chronic liver disease. 2 of 64 (3.1%) serum anti-HCV positive patients had HBsAg in their sera. Anti-HBs positive cases were 11 of 64 (17.2%.) anti-HCV positive chronic liver disease patients and isolated anti-HBc positive cases were 40 of 64 (62.5%). On the other hand, in normal control, the positive rate of anti-HBs and isolated anti-HBc were 57,4% and 24.3%(> in each (p<0,005, in both). Conclusion: In Korea, vertical transmission was the main source of HBV infection but HCV disease might be horizontal and sporadic. No remarkable difference in HBV infection rate between anti-HCV positive chronic liver disease patients and control persons. Superinfection of HCV on person who already was exposed to HBV may occur but this assumption could be depend on accurate testings for HBV and HCV. Some derangement in immune system and reaction or interaction between HBV and HCV should be considered in anti- HCV positive patients but before, isolated serum anti- HBc positive sera of chronic liver disease patients should be examined by confirmatory tests. To reduce the number of HCV patients, defining the evident source of the sporadically infected HCV cases could be helpful.
간세포암에서 경동맥문맥조영중 전산화단층촬영 100예의 의의
이헌주(Heon Ju Lee),김홍진(Hong Jin Kim),장재천(Jae Chun Chang),박복환(Bok Hwan Park),조재호(Jae Ho Cho),한건수(Kon Soo Han),심민철(Min Cheol Shim),권굉보(Kyung Bo Kwun),김태년(Tae Nyon Kim),정문관(Mun Kwan Jung) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.5
N/A We retrogradely analized the meannings of computed tomography during arterial portography (CTAP) compared with conventionally contrast enhanced computed tomography (conventional contrast CT) taken in 100 cases of hepatocellular carcinoma. We could find 57.8% additional borderline. lesions with CTAP in number of patients and 92.5% in numbers of masses. Portal vein invasion which was not demonstrated by conventional contrast CT could be detected by CTAP in 10 cases. In diagnosis of unilatral or bilateral lobe involvement for determinantion of treatment planning, CTAP could prevent 35.5% of mis-underdiagnosis of unilateral lobe involvement by demonstrating the nodule and/or portal vein invasion cf controlateral lobe. In conclusion, CTAP is very usefuI in detection of hidden borderline lesion, portal vein invasion, and recognition of portal venous flow nature in preserved portion of liver. Therefore CTAP is considered essential in pretreatment evaluation of hepatocellular carcinoma for determination of proper treatment principles.
B 형 간염 환자에서의 Delta agent 의 감염상
이헌주(Heon Ju Lee),정문관(Moon Kwan Chung),김종설(Chong Suhl Kim),최정규(Jung Gyu Choi),강찬규(Chan Kyu Kang),박화종(Wha Chong Park),최수봉(Soo Bong Choi) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1
N/A Delta agent is known to be highly infectious to HBV carriers. Despite of the high prevalence of HBV infection in Korea, only few studies of delta infection has been reported and its results are different from foreign study. Therefore authors evaluated the prevalence of delta infection by the sera from 40 HBsAg positive patients with various liver diseases, who consist of 15 patients with chronic active hepatitis, 10 with chronic persistent hepatitis, 3 with liver cirrhosis, 3 with hepatocellular carcinoma and 9 with acute viral hepatitis. Following results were obtained: 1) Anti-delta was detected in only 1 case of 40 cases. 2) It is suggested that delta infection is still rare in Korea despite of high endemicity of HBV infection.
Anti - HBc 단독양성인 만성간질환 환자에서 중합효소 연쇄반응을 이용한 혈청 HBV DNA 의 검출 , anti - HBe 및 anti - HBc 역가
이헌주(Heon Ju Lee),서민호(Min Ho Suh) 대한내과학회 1994 대한내과학회지 Vol.46 No.4
N/A Objectives: The interpretation of isolated anti-HBc is very complex. One of the possibility is the role of a surrogate marker for low level HBV carriers, particularly in high titers of anti-HBc. Methods : Hepatitis B virus (HBV) DNA was tested in 43 objects that have antibody against hepatitis B core antigen (anti-HBc) as the isolated serological marker of HBV infection by the polymerase chain reaction (PCR). Anti-HBc titers were presented by Cut off point Counter Per Minute/Patient Count Per Minute (C/P ratios). HBV marks were tested by Abbott kits by radioimmunoassay. Results : HBV DNA was detected in 9 of 43 (20.9%) patients with liver disease. C/P ratios in 43 patients were higher (12.9±8.1) than that of normal control (4.6±0.7, p<0.005) but no difference was found between HRV DNA positive and negative group. Anti-HBe was positive in 4 of 9 HBV DNA positive objects. Conclusions : HBV DNA amplification by the PCR is the best method for the diagnosis of low level HBV carriers among isolated anti-HBc positive objects, Anti-HRc titers can not be the only way that detect low level HBV carriers any more. Anti-HBe should be checked in objects with isolated anti-HBc who are under the suspicion of low level HBV carriers. More cautions sould be payed on evaluation and management of isolated anti-HBc positive blood for the diagnosis and prevention of HBV infection by medical personell, expecially in blood bank.
Anti - HBc 단독 양성자에서 GOT , GPT 치의 이상유뮤에 따른 Anti - HBc titer 의 비교
이헌주(Heon Ju Lee),김필영(Pill Young Kim),이현우(Hyun Woo Lee) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.2
N/A To study the clinical significance of isolated serum anti-HBc, the titer of the seum anti-HBc(C/P ratio-Cut off point CPM/Patient CPM) and changes of SGOT and SGPT were evaluated on the 2 groups of patients: 74 patients of group 1: seropositive for anti-HBc alone with normal sGOT and sGPT, 50 patients of group 2; seropositive for anti-HBc alone with abnormal SGOT and SGPTover6 months. The result is; The titer of anti-HBc was significantly higher in group 2 compared to group 1(4.61+ 0.68 vs 7.76+1.89, p<0.005). Specially, 5 subjects of hepatoma in group 2 was very high(18.77+3.39). On the basis of the above result we concluded that persistant presence of positive anti-HBc may indicate chronic infection and progression of the viral hepatic diseases. Therefore, anti-HBc test in addition to HBsAg and anti-HBs shoud be done to diagnose the HBV infection, and periodic follow up measurement of the titer of serum anti-HBc may be helpful to evaluate the status and prognosis of chronic hepatitis.