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이진항(Lee, Jin Hang),김광주(Kim, Kwang Ju),이명범(Lee, Myoung Beom),이만형(Lee, Man Hyung) 대한공간정보학회 2013 대한공간정보학회지 Vol.21 No.4
토지의 적성평가에 관한 지침에 따라 토지적성평가시 토지의 적성을 비교적 종합적으로 평가할 수 있으나, 기존지침의 평가지표 및 평가방법에 한계가 있다고 판단하였다. 현재 사용되고 있는 기본지표가 지역의 다양한 특성을 제대로 반영하기에는 한계가 있기 때문에 지역 특성을 반영할 수 있는 평가지표 및 평가방법이 필요한다고 보고 있다. 이러한 토지적성평가의 한계를 타개하기 토지적성평가시 새로운 지표로평가지표를 대체하였을 때 변화되는 적성등급까지 분석하는 실증적 연구이다. 이 연구에서는 관리지역 경계부 임야지역이 합리적인 평가가 이루어지는가를 확인하고, 토지의 적성평가에 관한 지침에 따른 관리지역 경계부 임야지역의 합리적인 평가방법을 확인하였다. 토지적성평가에 지역특성을 반영하기 위한 대체지표를 추가 하거나, 좀 더 효과적인 대체지표가 어떤 것인지를 확인하기 보다는 토지의 적성평가에 관한 지침에 따라 토지적성평가를 수행하였을 때, 관리지역 경계부 임야지역의 합리적인 평가방법을 제시하였다. Land Suitability Assessment can help to evaluate whether to preserve or to develop through analysis of various land characteristics. So, the evaluation index and method are very important for making the best result. The principle objective of this dissertation is to identify effective method that can make up for the distortion of land suitability value in the forest bordering the management area. The objective area of this study is comparative flat Jeungpyeong-gun. The procedures of the study are as follows. First, implement land suitability assessment as the normal index on Guideline. Second, verify land suitability grade about the forest bordering the management area. The third, redo land suitability assessment as two alternative index on *Guideline. The fourth, identify effective method between normal index and alternative index. The results of this tests show that the development suitability value is higher than preservation suitability value in the forest bordering the management area near existing development area. For that reason, this study needed to use substitution index in order to make up for the weakness. The level of land price and distance from road were main considerations. Finally, the derivative model is as follows. The derivative model confirmed the best assessment method in the forest bordering the management area near existing development area.
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김종기,이진항,서승준,김기홍 한국물리학회 2013 새물리 Vol.63 No.3
A biofilm is formed on dentine by oral bacteria, inducing tartar and coloring of a tooth as a long-term effect. Photodynamic bleaching is new treatment method, as apposed conventional bleaching methods, to remove dental biofilm while maintaining the enamel and the gingival. In this research, dental biofilm was colored by using coffee extract, and a photosensitizer, either methylene blue (MB) or radachlorin, was administrated prior to laser irradiation at 662 nm. Formation of the dental biofilm was assessed by using intavital microscopy and phase-contrast synchrotron X-ray imaging, and biofilm uptake of the photosensitizer was assessed using a confocal microscopy technique. At optimized light dose to produce a bleaching effect was obtained from this study. Stronger colorization was observed on the subgingival part of tooth compared with the supragingival region, and a weak bleaching effect was observed. The photodynamic bleaching efficacy was observed to depend on the dose,increasing with increasing light dose in the range of 5 - 50J/cm$^2$. Both radachlorin-photodynamic therapy (PDT) and MB-photodynamic therapy produce a bleaching effect, but radachlorin Photodynamic therapy (PDT) showed better efficacy under the same light dosimetry, and MB-PDT demonstrated a bleaching effect only at the second session of PDT treatment. 치아표면에 생성되는 생체막은 세균에 의해 유발되며 장기적으로tartar를 형성하여 치아변색을 증진시킨다. 기존 미백치료와는 달리광역학 치료법은 치아표면에 생성된 바이오막을 근원적으로 파괴하면서잇몸이나 치아면의 에나멜질을 유지해주는 새로운 방법이다. 치아표면에세균생체막을 커피 추출물에 변색 시킨 다음 광민감제, Methylene blue 또는 Radachlorin을 투여하고 660 nm의 레이저광을 조사하여치아변색치료효능을 측정하였다. 치아표면의 생물막의 추이는 intravital microscopy, 방사광-위상차 현미경법등으로 관찰하였다. 미백치료효과를유발하는 광선량/광민감제의 최적 농도를 본 연구를 통하여 도출하였다. 치아 및 치은에 형성된 생체막에 대한 변색은 치은변색이 매우 강하게나타나고 미백치료에 대한 효능도 저하하였다. 주어진 광민감제투여량에서 5 - 50 J 광선량의 증가에 따라 미백치료가 증가하였고,생물막의 손상정도와 미백치료효능이 비례함을 관찰하였다. radachlorin과 Methylene blue는 모두 미백효과를 보였으나Radachlorin이 20 J 이상에서 치료효능이 확연히 관찰된 반면, Methylene blue는 5 - 50 J 영역에서 두 번째 광역학 치료 시 미백효과가관찰되었다.
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정의만,Chun Zi Jin,장지현,Zai Hao Zhao,Chun Li Jin,이진항,이기백,김성준,김인규,Yin Hua Zhang 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
The myocardium in hypertensive heart exhibits decreased fatty acid utilization and contractile dysfunction, leading to cardiac failure. However, the causal relationship between metabolic remodeling and cardiomyocyte contractility remains unestablished. Transglutaminase 2 (TG2) has been known to promote ATP production through the regulation of mitochondrial function. In this study, we investigated the involvement of TG2 in cardiomyocyte contraction under fatty acid supplementation. Using TG2 inhibitor and TG2-deficient mice, we demonstrated that fatty acid supplementation activated TG2 and increased ATP level and contractility of cardiac myocyte from the normal heart. By contrast, in cardiac myocytes from angiotensin-II-treated rats and mice, the effects of fatty acid supplementation on TG2 activity, ATP level, and myocyte contraction were abolished. We found that TG2 was inhibited by S-nitrosylation and its level increased in hypertensive myocytes. Treatment with inhibitor for neuronal NOS restored fatty acidinduced increase of TG2 activity and myocyte contraction. Moreover, intracellular Ca2+ levels were increased by fatty acid supplementation in both normal and hypertensive myocytes, showing that S-nitrosylation of TG2 but not alteration of intracellular Ca2+ levels is responsible for contractile dysfunction. These results indicate that TG2 plays a critical role in the regulation of myocyte contractility by promoting fatty acid metabolism and provide a novel target for preventing contractile dysfunction in heart with high workload.
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