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급성 족근 관절 원위 경비인대결합 손상에서 TightRope<sup>TM</sup>를 이용한 수술의 단기 치료 결과
김도영,이준혁,박정현,조재호,Kim, Do Young,Lee, Jun Hyuck,Park, Jung Hyun,Cho, Jaeho 대한족부족관절학회 2016 대한족부족관절학회지 Vol.20 No.4
Purpose: The purpose of this study was to evaluate the clinical and radiologic outcome of syndesmosis fixation using TightRope$^{TM}$ (Arthrex, Naples, FL, USA) in acute syndesmosis injuries. Materials and Methods: Twenty-five consecutive patients with acute syndesmosis injuries, treated using TightRope$^{TM}$, were reviewed. Patients were evaluated preoperatively and at the last follow-up (at least 12 months postoperatively). Clinical outcomes were assessed using American Orthopaedics Foot and Ankle Society (AOFAS) ankle-hindfoot score and self-subjective satisfaction survey. Three radiologic parameters were evaluated two times at the preoperative and final follow up from the nonweightbearing ankle anteroposterior radiographs. Results: The mean AOFAS ankle-hindfoot score was 95.5 at the final follow-up. According to the satisfaction survey, 21 patients chose excellent, and four patients chose good. All radiologic parameters, including the mean tibiofibular clear space, mean tibiofibular overlap, and mean medial clear space on nonweightbearing ankle anteroposterior view, significantly improved after surgery. Complications occurred in only one patient who experienced knot irritation with infection. Conclusion: The short-term surgical results of syndesmosis fixation using TightRope$^{TM}$ were good to excellent, both clinically and radiographically. These results suggest that the fixation using TightRope$^{TM}$ is a valid option for acute syndesmosis injury.
이준석 ( Jun-seok Lee ),이준혁 ( Joon-hyuck Lee ),김갑조 ( Gab-jo Kim ),박상성 ( Sang-sung Park ),장동식 ( Dong-sik Jang ) 한국정보처리학회 2014 한국정보처리학회 학술대회논문집 Vol.21 No.1
근래에 계속 되는 이상기후현상과 대기오염에 관한 언론의 보도로 환경보호에 대한 관심이 그 어느 때 보다 높다. 지구온난화와 대기오염의 원인으로 지목되는 것 중 하나가 자동차 배기가스이며 고유가와 환경오염 등의 이유로 친환경 자동차의 생산필요성이 점점 더 커지고 있다. 이런 세계적 추세에 대응하기 위해 국내외 자동차산업업계에서는 친환경 자동차 연구에 매진하고 있다. 본 연구에서는 특허분석을 통하여 친환경 자동차 중 하나인 하이브리드 자동차의 국내외 기술연구동향을 파악하고 기술대응전략을 제안하도록 한다.
R&D 투자비용과 기업성과의 상관관계 분석에 대한 연구
안성준 ( Sung-jun Ahn ),이준혁 ( Joon-hyuck Lee ),김갑조 ( Gab-jo Kim ),박상성 ( Sang-sung Park ),장동석 ( Dong-sik Jang ) 한국정보처리학회 2014 한국정보처리학회 학술대회논문집 Vol.21 No.1
최근 여러 기업들이 경쟁력을 확보하기 위해서 기술력 확보에 많은 신경을 쓰고 있다. 특히 몇 년간 기업 간의 특허전쟁들로 인해서 기업들은 기술력을 객관적으로 입증 받으려고 하고 있으며, 이에 대한 노력으로 R&D 투자를 하고 있다. 하지만 R&D 투자와 기업성과의 관계에 대한 실증적 연구는 부족한 실정이다. 따라서 본 논문에서는 R&D 투자비용과 기업의 영업이익, 매출액, 특허등록 수에 대한 Pearson 상관관계분석을 수행했다.
저온 유도 시스템을 가진 재조합 대장균을 이용한 남극 세균 Flavobacterium frigoris PS1 유래 결빙방지단백질의 Pilot-scale 생산
김은재(Eun Jae Kim),이준혁(Jun Hyuck Lee),이성구(Sung Gu Lee),한세종(Se Jong Han) 한국생물공학회 2015 KSBB Journal Vol.30 No.6
Antifreeze proteins (AFP) inhibit growth and recrystallization of ice, and permit organisms to survive in cold environments. The AFP from an Antarctic bacterium, Flavobacterium frigoris PS1, FfIBP (Flavobacterium frigoris icebinding protein), was produced in E. coli using a cold shock induction system. The culture temperature was shifted from 37°C to 15°C and a 20 L culture scale was used. The final weights of dried cell and FfIBP were estimated to be 126 g and 8.4 g, respectively. The thermal hysteresis (TH) activity (1.53°C) of the produced FfIBP was 3.6-fold higher than that of the LeIBP (Leucosporidium ice-binding protein) produced in Picha. The current study demonstrates that large-scale production of FfIBP was successful and the result could be extended to further application studies using recombinant AFPs.
대장균을 이용한 북극 효모 Glaciozyma sp. 유래 재조합 결빙방지단백질 LeIBP의 Pilot-scale 생산
김은재(Eun Jae Kim),이준혁(Jun Hyuck Lee),이성구(Sung Gu Lee),한세종(Se Jong Han) 한국생물공학회 2017 KSBB Journal Vol.32 No.4
Antifreeze proteins (AFPs) have a unique feature to bind to ice nuclei, and are referred to ice-binding protein (IBP). The AFP, expressed in the cells of some polar organisms, controls cell damage in subzero temperature environments by inhibiting the ice growth and recrystallization. In this study, recombinant LeIBP (Leucosporidium ice-binding protein) from the arctic yeast Glaciozyma sp. (former known as Leucosporidium sp.) was produced in E. coli using a cold shock induction system. The final cell density and concentration of the purified LeIBP were measured to be 8.2 g/L and 1.1 g/L, respectively. The thermal hysteresis (TH) activity of LeIBP was 0.39±0.02°C at 13.25 mg/mL, which means that the scaleup was successfully performed for the production of recombinant LeIBP in heterologous bacterial expression system.
재조합 Pichia pastoris의 유가식 배양을 통한 남극세균 Flavobacterium frigoris PS1 유래 결빙방지단백질의 생산
김은재(Eun Jae Kim),도학원(Hackwon Do),이준혁(Jun Hyuck Lee),이성구(Sung Gu Lee),김학준(Hak Jun Kim),한세종(Se Jong Han) 한국생물공학회 2014 KSBB Journal Vol.29 No.4
Antifreeze proteins (AFP) inhibit ice growth to permit the survival of polar organisms in the cold environments. The recombinant AFP from an Antarctic bacterium, Flavobacterium frigoris PS1, FfIBP (Flavobacterium frigoris icebinding protein), was produced using Pichia pastoris expression system. The optimum fermentation temperature (30℃) and pH (5) for FfIBP production were determined using a fedbatch culture system. The maximal cell density and purified FfIBP were 112 g/L and 70 mg/L, respectively. The thermal hysteresis (TH) activity (0.85) of FfIBP obtained using a glycerol-methanol fed-batch culture system was 2-fold higher than that of the LeIBP (Leucosporidium ice-binding protein). This work allows for large-scale production of FfIBP, which could be extended to further application studies using recombinant AFPs.